A5022297560- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Nicotinic Acetylcholine Receptors Study
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
University of Ottawa
2024
uOttawa Brain and Mind Research Institute
2024
Lebanese American University
2019-2023
Exercise promotes learning and memory formation. These effects depend on increases in hippocampal BDNF, a growth factor associated with cognitive improvement the alleviation of depression symptoms. Identifying molecules that are produced during exercise mediate <i>Bdnf</i> expression will allow us to harness therapeutic potential exercise. Here, we report an endogenous molecule male mice induces <i>Mus musculus Bdnf</i> gene The metabolite lactate, which is released by muscles, crosses...
How individuals respond to chronic stress varies. Susceptible ultimately develop depression; whereas resilient live normally. In this study, our objective was examine the effect of branched-chain amino acids (BCAA), commonly used by athletes, on susceptibility stress. Male C57BL/6 mice were subjected daily defeat sessions a CD1 aggressor, for 10 days. On day11, behavior assessed using social interaction test, elevated plus maze and open field. Mice received BCAA leucine, isoleucine or valine...
Abstract Impaired mitochondrial function is a hallmark of aging and major contributor to neurodegenerative diseases. We have shown that disrupted dynamics typically found in alters the fate neural stem cells (NSCs) leading impairments learning memory. At present, little known regarding mechanisms by which progenitor survive adapt dysfunction. Using Opa1‐inducible knockout as model neurodegeneration, we identify decline neurogenesis due impaired cell activation proliferation, can be rescued...
Exercise promotes learning and memory recall as well rescues cognitive decline associated with aging. The positive effects of exercise are mediated by circulatory factors that predominantly increase Brain Derived Neurotrophic Factor (BDNF) signaling in the hippocampus. Identifying pathways regulate release various tissues during mediate hippocampal Mus musculus Bdnf expression will allow us to harness therapeutic potential exercise. Here, we report two weeks voluntary male mice activates...