A5065075528- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- Renal and Vascular Pathologies
- Ureteral procedures and complications
- Urinary and Genital Oncology Studies
- Pelvic floor disorders treatments
- Hormonal and reproductive studies
- Innovation, Technology, and Society
- Prostate Cancer Treatment and Research
- Sexual function and dysfunction studies
- Diverticular Disease and Complications
- Urologic and reproductive health conditions
- Organ Donation and Transplantation
- Minimally Invasive Surgical Techniques
- Pelvic and Acetabular Injuries
- Abdominal Trauma and Injuries
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Tuberous Sclerosis Complex Research
- Corporate Governance and Management
Alfried Krupp Hospital
2015-2025
Rijnstate Hospital
2024
University Medical Center of the Johannes Gutenberg University Mainz
2018-2022
Johannes Gutenberg University Mainz
2018-2022
Hamburg University of Technology
2016
Goethe University Frankfurt
2015
Heidelberg University
2005-2013
Chirurgische Universitätsklinik Heidelberg
2006-2011
University Hospital Heidelberg
2005-2009
Heidelberg University
2009
To prospectively examine the effects of margin status after radical prostatectomy (RP), location, and number positive surgical margins (PSMs) on biochemical clinical outcome, as even if there seems to be little debate that is a higher risk both local distant recurrence prostate cancer in face PSM significance RP only followed for progression most studies.From our prospective database, 406 consecutive well-described patients without neoadjuvant 'direct postoperative' adjuvant therapy who...
Little is known regarding functional outcomes after robot-assisted radical cystectomy (RARC) and intracorporeal neobladder (ICNB) reconstruction. To report on urinary continence (UC) erectile function (EF) at 12 mo RARC ICNB reconstruction investigate predictors of these outcomes. We used data from a multi-institutional database patients who underwent for bladder cancer. The cystoprostatectomy sensu stricto followed the conventional steps. was performed physician's discretion according to...
OBJECTIVE To compare the safety and outcome of potassium‐titanyl‐phosphate (KTP) Greenlight TM (Laserscope, AMS, Minnetonka, MN, USA) vaporization for treating benign prostatic hyperplasia (BPH) in prostates ≥80 vs <80 mL. PATIENTS AND METHODS In all, 204 consecutive patients were enrolled into this prospective study; 31 excluded from analysis various reasons, thus 173 (median age 66.8 years; 39 with mL) evaluated maximum urinary flow rate (Q max ), postvoid residual urine (PVR),...
To evaluate the influence of perinephric (PN) and renal sinus (RS) fat infiltration on cancer-specific survival beyond other prognostic factors, as Tumour-Node-Metastasis (TNM) classification system defines stage T3a cell carcinoma (RCC) perirenal and/or direct adrenal gland. Perirenal invasion is differentiated into RS PN infiltration, but not further classified for prognosis.From 1990 to October 2007 106 patients with advanced RCC (T3a) were followed prospectively at one academic centre;...
Abstract The enhancer of zeste homolog 2 ( EZH2 ) gene has been recently linked to human malignancies where it may serve as a new target for cancer therapy. Here, we analyzed expression in primary renal cell carcinoma (RCC) specimens and nontumorous tissue samples from adult kidney. transcripts were detectable all RCC examined. Expression levels significantly higher tumor p ≤ 0.0001) than normal Moreover, inhibition endogenous lines by RNA interference (RNAi) led reduced proliferation...
Harninkontinenz ist neben Störungen der erektilen Funktionsfähigkeit die häufigste Funktionseinschränkung nach radikaler Prostatektomie (RPE) beim Prostatakarzinom (PCa). Die deutsche S3-Leitlinie empfiehlt, Patienten über mögliche Auswirkungen Therapieoptionen zu informieren (darunter Inkontinenz). Allerdings liegen bislang nur ungenaue Daten zur Kontinenz aus Routineversorgung im deutschsprachigen Raum RPE vor, was Information erschwert. Ziel dieser Arbeit es, Häufigkeit und Ausprägung...
To assess whether under- or overweight at the time of surgery has any effect on survival patients with renal cell carcinoma (RCC), as obesity increases risk developing RCC.We prospectively evaluated 780 who had nephrectomy for RCC between 1990 and 2005. We used uni- multivariate Cox proportional hazards models to body mass index (BMI), tumour stage, Fuhrman grade, age, sex, histological type performance status cancer-specific (CSS). Patients were grouped according BMI (in kg/m(2)),...
Recent retrospective studies have challenged the current TNM classification of 7.0 cm to distinguish between T1 and T2 tumors. We reevaluated optimal tumor size cutoff point that independently differentiates patient prognosis beyond other accepted prognostic features.From 1990 October 2006, 398 patients who underwent radical nephrectomy for localized renal cell carcinoma (T1-T2, N0, M0) were followed prospectively. Median followup was 5.3 years 37 died related causes. The calculated...
Clear and accessible lay summaries are essential for enhancing the public understanding of scientific knowledge. This study aimed to evaluate whether ChatGPT-4 can generate high-quality that both accurate comprehensible prostate cancer research in Current Oncology. To achieve this, it systematically assessed ChatGPT-4's ability summarize 80 articles published journal between July 2022 June 2024 using two distinct prompt designs: a basic "simple" an enhanced "extended" prompt. Readability was...
ABSTRACT Objective Multiple system atrophy (MSA) is a progressive neurodegenerative disorder categorized as an atypical Parkinsonian syndrome, affecting extrapyramidal, pyramidal, cerebellar, and autonomic systems. Lower urinary tract dysfunction (LUTD), including urgency, frequency, urge incontinence, incomplete voiding, prevalent symptom, often appearing early in the disease. Conservative treatments, such anticholinergic alpha‐blocker therapies, frequently fail due to poor tolerance...
The antiapoptotic Livin/ML-IAP gene has recently gained much attention as a potential new target for cancer therapy. Reports indicating that livin is expressed almost exclusively in tumours, but not the corresponding normal tissue, suggested targeted inhibition of may present novel tumour-specific therapeutic strategy. Here, we compared expression renal cell carcinoma and non-tumorous adult kidney tissue by quantitative real-time reverse transcription-PCR, immunoblotting,...
Abstract Background The cost‐effectiveness of robot‐assisted partial nephrectomy (RAPN) vs. the open procedure is not established. Methods We estimated in‐hospital complications and cost RAPN (OPN) using an economic model. Costs incurred both intraoperatively in hospital were considered. US data extracted from existing literature. Results Mean costs $14,824 (95% CI $13,368–$16,898) for $15,094 $13,491–$17,140) OPN. Complications after occurred 23.3% 20.0–25.8%) OPN 36.1% 35.6–36.6%)...
Robotic surgery has gained popularity for the reconstruction of pelvic floor defects. Nonetheless, there is no evidence that robot-assisted reconstructive either appropriate or superior to standard laparoscopy performance procedures it sustainable. The aim this project was address proper role robotic using expert opinion.We set up an international, multidisciplinary group 26 experts participate in a Delphi process on robotics as applied surgery. comprised urogynecologists, urologists, and...
Background: Robot-assisted repair of benign ureteroenteric anastomotic strictures (UAS) provides an alternative to the open approach. We aimed report short-, medium-, and long-term outcomes for robotic UAS, provide a detailed video demonstration critical operative techniques in performing this procedure robotically. Materials Methods: Between January 2013 September 2022, 31 patients from seven institutions who previously underwent radical cystectomy subsequently developed UAS UAS....
OBJECTIVES To evaluate, in a prospective series of laparoscopic nephrectomies (LNs), the safety and feasibility en bloc stapling for resection occlusion vascular renal pedicle. PATIENTS AND METHODS Between October 2003 March 2006, we investigated intra‐ postoperative outcomes patients undergoing planned vein artery during LN. We also assessed complications at 6 12 months. RESULTS In all, 57 patients, with mean (range) age 59.8 (10–83) years, were enrolled. The indications LN were: cell...
To evaluate the effect of body mass index (BMI) on histopathological and clinical outcome in prostate cancer.In a prospective urological cancer database, 620 patients with had radical prostatectomy (RP) as curative treatment. The were categorized into three groups BMI (kg/m(2)); <or=25.0 (190, 'normal weight'), >25.0-30.0 (343, 'overweight') >30.0 (87, 'obese'). We evaluated features follow-up after RP. median (range) age men was 64.4 (41.1-80.1) years 5.5 (0.1-15.1) years. preoperative...
Until a few years ago, the treatment options for metastatic renal cell cancer (mRCC) were very limited. The growing understanding of molecular pathomechanisms underlying RCC allowed development new approaches. Meanwhile, several approved target-oriented substances from different drug classes are available mRCC. mechanism action vascular endothelial growth factor (VEGF) and VEGF receptor or mTOR inhibition is well documented by phase III trials reflected in current guidelines. However, no...
Introduction After the outbreak of COVID-19 unprecedented changes in healthcare systems worldwide were necessary resulting a reduction urological capacities with postponements consultations and surgeries. Material methods An email was sent to 66 hospitals focus on robotic surgery (RS) including link questionnaire (e.g. bed/staff capacity, surgical caseload, protection measures during RS) that covered three time points: representative baseline week prior COVID-19, March 16th-22nd April...
To assess the protein expression of Livin, an apoptosis inhibitor, in renal cell carcinoma (RCC) and to determine its prognostic relevance.Immunohistochemical staining for Livin was performed tissue microarrays (TMAs), including tumour cores, from patients with RCC who had undergone surgery. In 682 TMAs cytoplasmatic intensity nuclear quantity were evaluated, association progression-free survival (PFS) cancer-specific (CSS) analysed a multivariate Cox regression model.Over median (range)...