A5033759828- Facial Nerve Paralysis Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Reconstructive Facial Surgery Techniques
- Adrenal and Paraganglionic Tumors
- Ear Surgery and Otitis Media
- Sexual function and dysfunction studies
- Male Reproductive Health Studies
- Reproductive Health and Technologies
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Renal cell carcinoma treatment
- Urinary Bladder and Prostate Research
- Nutrition and Health in Aging
- Prostate Cancer Diagnosis and Treatment
- Ureteral procedures and complications
- Meningioma and schwannoma management
- Genital Health and Disease
- Artificial Intelligence in Healthcare and Education
- Reconstructive Surgery and Microvascular Techniques
- Patient-Provider Communication in Healthcare
- Ethics in Clinical Research
University of Regensburg
2021-2025
University Hospital Regensburg
2018-2025
Caritas-Krankenhaus St. Josef
2021-2025
St. Josef-Hospital
2023
Chang Gung University
2021
University Medical Center Utrecht
2021
Chang Gung Memorial Hospital
2021
Abstract Purpose Successful treatment options for ureteral strictures are limited. Surgical such as ileal interposition and kidney autotransplantation difficult associated with morbidity complications. Techniques Boari flap psoas hitch limited to distal strictures. Only case studies on the success of open buccal mucosa graft (BMG) ureteroplasty exist this date. The purpose study was evaluate BMG without omental wrap. Methods In single-center retrospective between July 2020 January 2023, we...
We assessed a wide array of body composition parameters to identify those most relevant as prognostic tools for patients undergoing radical cystectomy (RC) due bladder cancer (BC).In this retrospective, single-center study, preoperative computed tomography (CT) scans 657 were measured at the level 3rd lumbar vertebra (L3) determine common indices including sarcopenia, myosteatosis, psoas muscle index (PMI), subcutaneous and visceral fat (SFI VFI), visceral-to-subcutaneous ratio (VSR),...
To assess the feasibility of trial recruitment and confirm that retroperitoneal robotic partial nephrectomy (RRPN) has same oncological efficacy as transperitoneal (TRPN), with time advantages less peri-operative morbidity, in a randomised controlled (RCT). The study was designed single-centre, open-label, RCT. Patients suspected localised renal cell carcinoma referred for were 1:1 ratio to receive either TRPN or RRPN. primary outcomes feasibility, postoperative mobility pain perception....
Clear and accessible lay summaries are essential for enhancing the public understanding of scientific knowledge. This study aimed to evaluate whether ChatGPT-4 can generate high-quality that both accurate comprehensible prostate cancer research in Current Oncology. To achieve this, it systematically assessed ChatGPT-4's ability summarize 80 articles published journal between July 2022 June 2024 using two distinct prompt designs: a basic "simple" an enhanced "extended" prompt. Readability was...
Abstract Objectives To evaluate and compare surgical techniques for robot‐assisted reconstruction of recurrent bladder neck stenosis (BNS). BNS following a simple prostatectomy represents rare but challenging condition in operative urology. Various robotic reconstructive have been described, showing differing success rates. This monocentric case series reports on three distinct approaches managing BNS. Patients methods A retrospective analysis was conducted patients undergoing repair at our...
The abundant potential arising from various applications of artificial intelligence is gradually influencing academic and scientific communication. This study examines the suitability ChatGPT‑4 for generating layperson's summaries (LS) articles published in four journals within European Urology family compares quality these newly generated LS with original texts. A total 327 on prostate cancer between January 1, 2023, June 30, 2024, were analyzed. patient using both a basic an advanced...
The zygomaticus major (ZM) is important for the human smile. There are conflicting data about whether zygomatic or buccal branches of facial nerve responsible its motor innervation. literature provides no precise distinction transition zone between these two branch systems. In this study, a definition to distinguish at level body zygoma proposed. light definition, we conducted an anatomical study determine how source innervation ZM was distributed. A total 96 fresh-frozen cadaveric halves...
The facial nerve is responsible for any expression channeling human emotions. Facial paralysis causes asymmetry, lagophthalmus, oral incontinence, and social limitations. dynamics may be re‐established with cross‐face‐nerve‐grafts (CFNG). Our aim was to reappraise the zygomaticobuccal branch system relevant reanimation surgery respect anastomoses crossings. Dissection performed on 106 halves of 53 fresh frozen cadavers. Study endpoints were quantity relative thickness branches, correlation...
We developed a time-efficient semi-automated axon quantification method using freeware in human cranial nerve sections stained with paraphenylenediamine (PPD). It was used to analyze total of 1238 facial and masseteric biopsies. The technique validated by comparing manual 129 (10.4%) randomly selected software-based demonstrated sensitivity 94% specificity 87%. Semi-automatic counting significantly faster (p < 0.001) than counting. took 1 hour 47 minutes for all biopsies (averaging 50 sec...
Radical nephroureterectomy (NUE) is the gold standard treatment for high-risk urothelial cancer of upper urinary tract (UTUC). Besides sarcopenia and frailty, fat distribution moving increasingly into focus. Components body composition were assessed in patients undergoing NUE due to UTUC. The study cohort included 142 patients. By using CT-based measurements, skeletal muscle index (SMI), subcutaneous adipose tissue (SATI), visceral (VATI) measured at height third lumbar vertebra. Overall...
Objective To develop a prognostically relevant scoring system for stage pT1 non‐muscle‐invasive bladder cancer (NMIBC) incorporating tumour budding, growth pattern and invasion because the World Health Organisation grading shows limited prognostic value in such patients. Patients Methods The tissue specimens clinical data of 113 patients with NMIBC who underwent transurethral resection were retrospectively investigated. Tumour patterns evaluated categorised into two grade groups (GGs). GGs...
Facial palsy (FP) is a debilitating nerve pathology. Cross Face Nerve Grafting (CFNG) describes surgical technique that uses grafts to reanimate the paralyzed face. The sural has been shown be reliable graft with little donor side morbidity. Therefore, we aimed investigate microanatomy of nerve. Biopsies were obtained from 15 FP patients who underwent CFNG using grafts. Histological cross-sections fixated, stained PPD, and digitized. Histomorphometry validated software-based axon...
Background The marginal mandibular branch (MMB) of the facial nerve provides lower lip symmetry apparent during human smile or crying and is mandatory for vocal phonation. In treating palsy patients, so far, little attention directed at MMB in reanimation surgery. However, isolated paralysis may occur congenital, Bell's iatrogenic surgery, prone to its anatomical course. A variety therapies address with either weakening functional side reconstruction paralyzed side. To further clarify...
Abstract Purpose The higher detection efficacy of PSMA PET for oligometastatic recurrence prostate cancer has promoted new loco-regional treatment options. PSMA-targeted radioguided surgery (PSMA-RGS) was introduced to facilitate salvage small tumor deposits. objectives this retrospective analysis are describe an independent single-center consecutive cohort patients undergoing PSMA-RGS and evaluate its clinical oncological outcomes. Method Between 2018 2022, 53 were treated with 50 available...
Early persistent facial paralysis is characterized by intact muscles of expression through maintained perfusion but lacking nerve supply. In reanimation procedures aiming at restoration tone and dynamics, neurotization a donor performed. Critical for reanimating target axonal capacity both recipient nerves. cases complete paralysis, the proximal stump extratemporal trunk may be selected as site coaptation. To further clarify histological basis this procedure we conducted human cadaver study...
Facial palsy (FP) is a functional disorder of the facial nerve involving paralysis mimic muscles. According to principle “time muscle,” early surgical treatment tremendously important for preserving musculature if there are no signs function recovery. In 49-year-old female patient, even 19 months after onset FP, successful neurotization was still possible by V-to-VII transfer and cross-face grafting. Our patient suffered from complete FP vestibular schwannoma surgery. With continuous...
Background: A commonly seen issue in facial palsy patients is brow ptosis caused by paralysis of the frontalis muscle powered frontal branch nerve. Predominantly, static methods are used for correction. Functional restoration concepts include transfer deep temporal trigeminal nerve and cross-facial grafts. Both techniques can neurotize original mimic muscles early cases or power transplants late cases. Because axonal capacity particularly important graft procedures, authors investigated...
RC represents a viable treatment option for certain NMIBC patients. However, studies investigating morbidity in the context of are scarce. The goal current study was to assess and compare after performed patients with MIBC identify risk factors severe short-term complications.Medical records 521 who underwent bladder cancer were retrospectively reviewed. Patients divided into MIBC. groups compared complications identified.RC 123 (23.6%). Histological upstaging seen 47 (38.2%) 231 (58%, p <...
Abstract Metastases arise from disseminated cancer cells (DCCs) that often lodge to distant organs long before diagnosis of the primary tumor. Unfortunately, efficacy (neo-)adjuvant therapies against DCCs remains uncertain. Here, we harnessed novel patient-derived ex vivo models identify promising candidate targeting and explored impact unique microenvironment metastatic target on phenotypes drug responses DCCs. We screened disaggregated lymph node (LN) or bone marrow (BM) samples melanoma,...
Sarcopenia, defined as age-associated loss of skeletal muscle function and mass, is a negative prognostic marker for survival in several tumor entities. However, data evaluating the impact sarcopenia fat distribution on penile cancer are rarely described. We performed retrospective study including 38 patients who were diagnosed with squamous cell carcinoma penis. By measuring mass at axial abdominal computed tomography images third lumbar vertebra body composition parameters index (SMI),...
Introduction: Early radical cystectomy (eRC) can be performed for high or very risk non-muscle-invasive bladder cancer (NMIBC). Whether immediate eRC is beneficial still unclear. The objective of this study was to compare outcomes between eRC, delayed and (RC) at diagnosis muscle-invasive (MIBC). Methods: single-center cohort consisting patients with RC 2008 2020 divided into four populations: who received within three months NMIBC (IEC), recurrence (REC), underwent after primary MIBC...