A5053398470- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
- Chronic Kidney Disease and Diabetes
- Polyomavirus and related diseases
- Neurological Complications and Syndromes
- Genetic and Kidney Cyst Diseases
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Acute Kidney Injury Research
- Liver Disease and Transplantation
- Pharmacological Effects and Toxicity Studies
- Viral Infections and Vectors
- Advanced Glycation End Products research
- Electrolyte and hormonal disorders
- Organ and Tissue Transplantation Research
- Pregnancy and Medication Impact
- Metabolism and Genetic Disorders
- Renal cell carcinoma treatment
- Parvovirus B19 Infection Studies
- Blood Pressure and Hypertension Studies
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
German Center for Infection Research
2025
Nierenzentrum Heidelberg
2012-2024
Friedrich Schiller University Jena
2022
Klinikum Braunschweig
2020
Palo Alto Institute
2016
Dialyse Centrum Groningen
2016
World Economic Forum
2016
Heidelberg University
2008-2015
The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Donors is intended to assist medical professionals who evaluate living kidney donor candidates provide care before, during after donation. guideline development process followed Grades Recommendation Assessment, Development, (GRADE) approach recommendations are based systematic reviews relevant studies that included critical appraisal quality evidence strength...
The European Best Practice Guideline group (EBPG) issued guidelines on the evaluation and selection of kidney donor transplant candidates, as well post-transplant recipient care, in year 2000 2002. new Renal board decided 2009 that these needed updating. In order to avoid duplication efforts with disease improving global outcomes, which published clinical practice care recipients, we did not address issues present guidelines. guideline was developed following a rigorous methodological...
OBJECTIVE Establishing Caenorhabditis elegans as a model for glucose toxicity–mediated life span reduction. RESEARCH DESIGN AND METHODS C. were maintained to achieve concentrations resembling the hyperglycemic conditions in diabetic patients. The effects of high on span, glyoxalase-1 activity, advanced glycation end products (AGEs), and reactive oxygen species (ROS) formation mitochondrial function studied. RESULTS High reduced mean from 18.5 ± 0.4 16.5 0.6 days maximum 25.9 23.2 days,...
HIV-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex and comorbid as well injury resulting from prolonged exposure to antiretroviral therapy or opportunistic infections. Clinical guidelines disease prevention treatment in largely extrapolated studies the general population, do not fully incorporate existing knowledge of unique HIV-related pathways genetic factors that...
Summary Studies of mutations affecting lifespan in Caenorhabditis elegans show that mitochondrial generation reactive oxygen species (ROS) plays a major causative role organismal aging. Here, we describe novel mechanism for regulating ROS production and C . elegans: progressive protein modification by the glycolysis‐derived dicarbonyl metabolite methylglyoxal (MG). We demonstrate activity glyoxalase‐1, an enzyme detoxifying MG, is markedly reduced with age despite unchanged levels...
Kidney graft function after transplantation can be improved through pharmacological donor pretreatment to limit organ injury from cold preservation.To determine whether of brain-dead donors with low-dose dopamine improves early in human renal transplant recipients.Randomized, open-label, multicenter, parallel-group trial 264 deceased heart-beating and 487 subsequent transplants performed at 60 European centers between March 2004 August 2007 (final follow-up, December 31, 2008). Eligible were...
Differences in actuarial graft survival according to donor gender have been reported for renal allografts and cardiac hepatic allografts, but the latter small series with limited biostatistical power. Using large database of Collaborative Transplant Study (CTS), this study is an evaluation recipient (n = 124,911), 25,432), 16,410) transplants. Confounders, such as calendar year, geographical area, race, age, HLA mismatch, cold ischemia time, others, well interaction terms were taken into...
It was reported recently that treatment of kidney transplant recipients with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II type 1 receptor blockers (ARB) is associated strikingly improved long-term graft and patient survival. This finding has important implications for future posttransplantation therapy recommendations. In an analysis 17,209 1744 heart recipients, association ACEI/ARB outcome could not be confirmed. concluded recommendations a widespread use in are unwarranted.
A main challenge for targeting chronic kidney disease (CKD) is the heterogeneity of its causes, co-morbidities and outcomes. Patients under nephrological care represent an important reference population, but knowledge about their characteristics limited. We enrolled 5217 carefully phenotyped patients with moderate CKD [estimated glomerular filtration rate (eGFR) 30–60 mL/min per 1.73 m2 or overt proteinuria at higher eGFR] routine nephrologists into German Chronic Kidney Disease (GCKD)...
Acute kidney injury (AKI) is associated with a high mortality of up to 60%. The mode renal replacement therapy (intermittent versus continuous) has no impact on patient survival. Sustained low efficiency dialysis using single-pass batch system (SLED-BD) recently been introduced for the treatment dialysis-dependent AKI. To date, however, only limited evidence available in comparison SLED-BD continuous veno-venous hemofiltration (CVVH) intensive care unit (ICU) patients AKI.Prospective,...
Chronic kidney disease (CKD) is increasingly recognized as a global health problem. The conditions leading to CKD, the impact of CKD and prognosis differ markedly between affected individuals. In particular, renal failure cardiovascular mortality are competing risks for patients. Opportunities targeted intervention very limited so far require an improved understanding natural course risk factors associated with various clinical end points co-morbidities well underlying pathogenic...
It is a matter of debate whether pancreas allografts independently contribute to renal allograft and patient survival in individuals who have type 1 diabetes receive simultaneous kidney transplant (SPK). Using data from the Collaborative Transplant Study, we studied patients had were recipients deceased-donor kidneys (DDK), living-donor (LDK), or SPK. We analyzed graft rates with maximum 18 yr follow-up. DDK inferior compared LDK SPK recipients. superior initially, but demonstrated equal...
Dysregulations concerning the composition and function of regulatory T cells (T(regs)) are assumed to be involved in pathophysiology complicated pregnancies. We used six-colour flow cytometric analysis demonstrate that total CD4(+) CD127(low+/-) CD25(+) forkhead box protein 3 (FoxP3)(+) T(reg) cell pool contains four distinct subsets: DR(high+) CD45RA(-), DR(low+) DR(-) CD45RA(-) T(regs) naive CD45RA(+) T(regs). During normal course pregnancy, most prominent changes were observed between...
Reduced kidney function is a risk factor for hyperuricaemia and gout, but limited information on the burden of gout available from studies patients with chronic disease (CKD). We therefore examined prevalence correlates in large prospective observational German Chronic Kidney Disease (GCKD) study.Data 5085 CKD aged 18-74 years an estimated glomerular filtration rate (eGFR) 30-<60 mL/min/1.73 m(2) or eGFR ≥60 overt proteinuria at recruitment non-missing values self-reported medications urate...