A5029363686- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Long-Term Effects of COVID-19
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Neurological Complications and Syndromes
- Retinal Imaging and Analysis
- Renal and Vascular Pathologies
- Sepsis Diagnosis and Treatment
- Diabetes Treatment and Management
- Renal function and acid-base balance
- Retinal and Optic Conditions
- Respiratory Support and Mechanisms
- Noise Effects and Management
- Intramuscular injections and effects
- Clinical Nutrition and Gastroenterology
- Sodium Intake and Health
- Glaucoma and retinal disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Disease Management Strategies
- Cardiovascular Health and Disease Prevention
- Retinal Diseases and Treatments
- Metabolism and Genetic Disorders
- SARS-CoV-2 and COVID-19 Research
University Hospital Regensburg
2021-2025
University of Regensburg
2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
2014-2020
Universitätsklinikum Erlangen
2016-2020
University of Pennsylvania
2016
Klinikum rechts der Isar
2010
Abstract Metabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onset hyperglycemia complications preexisting diabetes have been observed in patients. Here, we performed a comprehensive analysis pancreatic autopsy tissue from patients using immunofluorescence, immunohistochemistry, RNA scope electron microscopy detected SARS-CoV-2 viral infiltration beta-cells all Using pseudoviruses, confirmed that isolated human islet cells permissive to infection....
A main challenge for targeting chronic kidney disease (CKD) is the heterogeneity of its causes, co-morbidities and outcomes. Patients under nephrological care represent an important reference population, but knowledge about their characteristics limited. We enrolled 5217 carefully phenotyped patients with moderate CKD [estimated glomerular filtration rate (eGFR) 30–60 mL/min per 1.73 m2 or overt proteinuria at higher eGFR] routine nephrologists into German Chronic Kidney Disease (GCKD)...
Patients with chronic kidney disease (CKD) bear a substantial burden of comorbidities leading to the prescription multiple drugs and risk polypharmacy. However, data on medication use in this population are scarce.A total 5217 adults an estimated glomerular filtration rate (eGFR) between 30 60 mL/min/1.73 m2 or eGFR ≥60 mL/min/1.73m2 overt proteinuria (>500 mg/day) were studied. Self-reported current assessed at baseline (2010-12) after 4 years follow-up (FU). Prevalence factors associated...
Abstract Background Empagliflozin has been shown to reduce cardiovascular mortality, but the underlying pathogenetic mechanisms are poorly understood. It was previously demonstrated that empagliflozin improved arterial stiffness. Methods Our analysis comprising 58 patients with type 2 diabetes mellitus identifies factors triggering improvement of All participated in an investigator-initiated, prospective, double-blind, randomized, placebo-controlled, interventional clinical trial (...
The role of venovenous extracorporeal membrane oxygenation (VV ECMO) in patients with COVID-19-induced acute respiratory distress syndrome (ARDS) still remains unclear. Our aim was to investigate the clinical course and outcome those identify factors associated need for prolonged ECMO therapy.A retrospective single-center study on VV COVID-19-associated ARDS performed. Baseline characteristics, ventilatory parameters, laboratory virological results were evaluated over time. Six months...
Damage of mitochondrial DNA (mtDNA) with reduction in copy number has been proposed as a biomarker for dysfunction and oxidative stress. Chronic kidney disease (CKD) is associated increased mortality risk cardiovascular disease, but the underlying mechanisms remain incompletely understood. Here we investigated prognostic role mtDNA cause-specific 4812 patients from German Kidney Disease study, an ongoing prospective observational national cohort study CKD stage G3 A1-3 or G1-2 overt...
Abstract Between April and June 2020, i.e., during the first wave of pandemic coronavirus disease 2019 (COVID-19), 55 patients underwent long-term treatment in intensive care unit at University Hospital Regensburg. Most them were transferred from smaller hospitals, often due to need for an extracorporeal membrane oxygenation system. Autopsy was performed 8/17 COVID-19-proven after (mean: 33.6 days). revealed that typical pathological changes occurring early stages (e.g., thrombosis,...
Chronic kidney disease (CKD) is a global health burden, yet it still underrepresented within public agendas in many countries. Studies focusing on the natural history of CKD are challenging to design and conduct, because long time-course progression, wide variation etiologies, large amount clinical variability among individuals with CKD. With difference health-related behaviors, healthcare delivery, genetics, environmental exposures, this greater across countries than one locale may not be...
Telomere length is known to be inversely associated with aging and has been proposed as a marker for aging-related diseases. attrition can accelerated by oxidative stress inflammation, both commonly present in patients chronic kidney disease. Here, we investigated whether relative telomere mortality large cohort of disease stage G3 A1-3 or G1-2 overt proteinuria (A3) at enrollment. Relative was quantified peripheral blood quantitative PCR method 4,955 from the GCKD study, an ongoing...
Introduction The association of delayed graft function (DGF) and biopsy proven acute rejection (BPAR) renal allografts is controversial. Borderline rejections comprise a major portion results but the significance such histologic changes debated. present study explores impact DGF on BPAR with special emphasis discriminating effects borderline rejection. Methods Single center analysis 417 deceased donor kidney recipients (age>18; transplantation date 1/2008–2/2015). Patients primary...
ABSTRACT Background Persons with chronic kidney disease (CKD) are at increased risk of adverse events, early mortality and multimorbidity. A detailed overview event types rates from a large CKD cohort under regular nephrological care is missing. We generated an interactive tool to enable exploration events their combinations in the prospective, observational German (GCKD) study. Methods The GCKD study enrolled 5217 participants estimated glomerular filtration rate 30–60 or >60...
Kidney transplantation (KTx) is the treatment of choice for patients with end-stage renal disease. Cytomegalovirus (CMV) infection remains a serious complication KTx. The most vulnerable are naïve recipients (R-) transplanted from CMV-seropositive donor (D+). Mammalian target rapamycin inhibitors (mTOR-I) have been shown to advantages over mycophenolate in terms CMV infections. In this study, we addressed effect preemptive conversion mTOR-I before ending prophylaxis valganciclovir high-risk...
Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects disease and refine treatment strategies but also improve clinical decision-making. For decision-making in particular, prognostic factors a lethal course would be highly relevant.
Spectral-domain optical coherence tomography (SD-OCT) represents a reliable tool for retinal layer volume and thickness measurement. The aim of this study was to evaluate changes indicating neurodegenerative processes in patients with end-stage renal disease (ESRD) compared healthy controls. This cross-sectional, single-center comprising 32 ESRD 38 Sectoral nerve fiber (RNFL) volumes were obtained by SD-OCT. Age- gender-adjusted such as total (p = 0.037), ganglion cell (GCL, p 0.003), -...
Chronic kidney disease (CKD) engenders salt-sensitive hypertension. Whether or not tissue Na+ accumulation is increased in CKD patients remains uncertain. How affected after renal transplantation has been assessed.We measured amount 31 (stage 5) and prospectively evaluated content at 3 6 months, following living-donor transplantation. Additionally, pre- post-transplantation data were compared to age- sex-matched control subjects. 23Na-magnetic resonance imaging (23Na-MRI) was used quantify...
Background Patients with COVID-19 and severe acute respiratory failure may require veno-venous extracorporeal membrane oxygenation (VV ECMO). Yet, this procedure is resource-intensive high mortality rates have been reported. Thus, predictors for identifying patients who will benefit from VV ECMO would be helpful. Methods This retrospective study included 129 failure, had received at the University Medical Center Regensburg, Germany, between 1 March 2020 31 December 2021. Patient-specific...
We report a case of 64-year-old female patient with severe metabolic acidosis. Inhibition 5-oxoprolinase by flucloxacillin was found to be the cause derailment.
Initiation of antihypertensive drug treatment in low-risk individuals with grade 1 hypertension is under debate. The aim this study was to examine the impact mildly elevated blood pressure (BP) on early neurodegenerative processes independent ageing.Sixty-two were included study: 25 young (aged <40 years) and 37 older ≥40 at low cardiovascular risk most. Macular retinal layer volumes both eyes determined by SD-OCT. Total volume but also each inner separately including nerve fiber (RNFL),...
Abstract Transplant centers now accept living donors with well‐controlled hypertension. Little is known whether hypertension in affects recipient's kidney function. We aimed to examine potential differences kidneys from hypertensive compared normotensive respect renal function over 36 months and histologic findings at transplantation (T0) 12 after (T1). Retrospective single‐center analysis of 174 donor‐recipient pairs (age > 18; date 1/2008‐3/2016). Hypertension was defined as being on...
BACKGROUND:Arterial hypertension (HT) is a leading cause of cardiac hypertrophy and heart failure. Ubiquitin-specific peptidase 18 (USP18) has been recently described as factor that prevents myocardial dysfunction. The present study measured serum USP18 levels in normotensive (n=29), isolated diastolic hypertensive (n=20), systolic-diastolic (n=30) male participants correlated these results with biochemical parameters are included routine assessments patients hypertension. MATERIAL AND...
Abstract Background: Data of critically ill COVID-19 patients are being evaluated worldwide, not only to understand the various aspects this disease and refine treatment strategies but also improve clinical decision-making. For last aspect in particular, predictors a lethal course would be highly relevant. Methods: In retrospective cohort study, we analyzed first 59 adult Covid-19 treated one intensive care units University Medical Center Regensburg, Germany. Using uni- multivariable...
The ongoing SARS-COV-2 pandemic has severe implications for people and healthcare systems everywhere. In Germany, worry about the consequences of led to deferral non-emergency surgeries. Tumor surgery accounts a large volume in field visceral cannot be considered purely elective. It is not known how changed surgical tumor patients.Retrospective analysis amount oncological surgeries three academic departments Bavaria, 2020. Procedures were split into subgroups: Upper Gastrointestinal (Upper...