A5051298902- Multiple Myeloma Research and Treatments
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Parathyroid Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Tuberculosis Research and Epidemiology
- Bone health and treatments
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- Cancer Treatment and Pharmacology
- Diagnosis and treatment of tuberculosis
- COVID-19 Impact on Reproduction
- Agriculture, Plant Science, Crop Management
- Wheat and Barley Genetics and Pathology
- Bone health and osteoporosis research
- Chronic Myeloid Leukemia Treatments
- Electrospun Nanofibers in Biomedical Applications
- Gastrointestinal motility and disorders
- PARP inhibition in cancer therapy
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Botany and Plant Ecology Studies
- Anesthesia and Neurotoxicity Research
- Dermatological and COVID-19 studies
- Vascular Anomalies and Treatments
Federal Almazov North-West Medical Research Centre
2019-2025
Institute of Experimental Medicine
2019-2025
Clinical Infectious Disease Hospital named after S.P. Botkin
2020-2024
Saint Petersburg State Pediatric Medical University
2024
St. Petersburg State Health Care Foundation "Mariinsky City Hospital"
2024
St. Petersburg State Medical Academy "City Hospital No. 26"
2024
Ministry of Health of the Russian Federation
2024
Institute of Molecular Pathology and Pathomorphology
2024
Russian Research Institute of Hematology and Transfusiology
2014-2023
Saratov State University
2022-2023
Abstract Metabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onset hyperglycemia complications preexisting diabetes have been observed in patients. Here, we performed a comprehensive analysis pancreatic autopsy tissue from patients using immunofluorescence, immunohistochemistry, RNA scope electron microscopy detected SARS-CoV-2 viral infiltration beta-cells all Using pseudoviruses, confirmed that isolated human islet cells permissive to infection....
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November–December 2019 Wuhan, China, and has rapidly spread around the world causing severe health socioeconomical damage to entire civilization. The key feature of disease (COVID-19), caused by SARS-CoV-2, is upper tract infection, which may be complicated bilateral pneumonia. Angiotensin converting enzyme (ACE2) been identified as a host factor, required for virus entry into cells. Interestingly, ACE2...
Relevance of the problem a new COVID-19 coronavirus infection is obvious. Among its most important aspects that require special study, are pathogenesis and morphological changes in severe forms disease. Material methods. The analysis 18 autopsy observations was carried out. Along with routine assessment macro – microscopic changes, immunohistochemical studies lungs other organs were performed using sera against antigens CD2,3,4,5,7, 20,31,34, 56,57,69; presence Fe 2+ 3+ detected liver....
Arterial hypertension (AH) is associated with heart and chronic kidney disease (CKD). However, the precise mechanisms of myocardial remodeling (MR) in settings CKD remain elusive. We hypothesized that TRPC6, calcineurin/NFAT, Wnt/β-catenin signaling pathways are involved development MR background AH. Early was induced by performing a 5/6 nephrectomy (5/6NE) spontaneously hypertensive rats (SHR-NE). Sham-operated (SO) SHR (SHR-SO) Wistar Kyoto (WKY-SO) served as controls. Systolic blood...
In this study, we investigated the effect of three different probiotics, namely, a combination Lactobacillus acidophilus (LA–5) and Bifidobacterium animalis subsp. lactis (BB–12), Saccharomyces boulardii, Enterococcus faecium L3 on myocardial infarct size in rats with diet-induced obesity (DIO) chemically-induced colitis (CIC). Potential associations between effects probiotics ischemia-reperfusion injury gut microbiome patterns as well serum levels pro- anti-inflammatory cytokines,...
Objective. To evaluate the effect of NO added to sweep gas oxygenator during cardiopulmonary bypass (CPB) on liver and kidneys in pigs. Methods. An experiment was carried out 10 pigs undergoing cardiac surgery using CPB. at a concentration 100 ppm for animals experimental group (CPB-NO, n = 5). Animals control (CPB-contr, 5) did not receive oxygenator. The CPB lasted 4 h, followed by postoperative monitoring 12 h. assess injury kidneys, levels alanine aminotransferase (ALT), aspartate (AST),...
The development of biocompatible composite materials is in high demand many fields such as biomedicine, bioengineering, and biotechnology. In this study, two series poly (D,L-lactide) (ε-caprolactone)-based films filled with neat modified (glutamic acid) (PGlu) nanocrystalline cellulose (NCC) were prepared. An analysis scanning electron atomic force microscopies’ results shows that the modification NCC favored better distribution nanofiller polymer matrix. Investigating ability developed to...
Our objective was to develop a model of systemic inflammatory response syndrome (SIRS) by chemical induction colon injury and antibiotic-associated intestinal dysbiosis in rats with primary visceral obesity (PVO) for studies myocardial resistance ischemia-reperfusion injury. The experiments were performed adult Wistar male PVO under improved conditions conventional animal clinic. chemically induced disease (CIICD) accomplished intragastric administration mixture broad-spectrum antimicrobial...
In May 2020, a pregnant woman in her 37th pregnancy week was diagnosed with COVID-19 St. Petersburg Russia. All treatments failed and the patient died after 11 days due to acute respiratory distress syndrome. A stillborn child removed by caesarian section. Pathological investigations showed that antenatal asphyxia aspiration pneumonia. The positive for SARS-CoV-2 immunohistochemical viral infection cellular changes several organs such as pancreas, brain, spleen, adrenals. These results...
Mesenchymal stromal cells (MSC) 'educated' by tumor are an essential component of the multiple myeloma (MM) microenvironment (TME) involved in progression. Transcription tandemly repeated (TR) non-coding DNA is often activated many tumors and required for progression cancer genome reorganization. The aim work was to study functional properties including TR transcription profile MSC from hematopoietic niche treated MM patients. Healthy donors (HD) patients after bortezomib-based treatment...
A technology to create a cell-seeded fibrin-based implant matching the size and shape of bone defect is required an anatomical implant. The aim study was develop fibrin gel creation that has same as at site implantation. Using computed tomography (CT) images, molds representing defects were created by 3D printing. form filled with glue human dental pulp stem cells (DPSC). viability, set surface markers osteogenic differentiation DPSC grown in along clot retraction time evaluated. In mice,...
Background Recent evidence suggests that antibiotic-induced changes in the composition of intestinal microflora, as well systemic immunoendocrine effects result from them, can modulate myocardial tolerance to ischemia-reperfusion injury. The aim this study was investigate tetracycline (TTC) on infarct size isolated hearts obtained obese rats with chemically-induced colitis (CIC). association between TTC-induced and microbiome plasma levels cytokines short-chain fatty acids (SCFAs) also...
The initial phases of molecular and cellular maladaptive bone responses in early chronic kidney disease (CKD) remain mostly unknown. We induced mild CKD spontaneously hypertensive rats (SHR) by either causing arterial hypertension lasting six months (sham-operated rats, SO6) or its’ combination with 3/4 nephrectomy two (Nx2 Nx6, respectively). Sham-operated SHRs (SO2) Wistar Kyoto (WKY2) a two-month follow-up served as controls. Animals were fed standard chow containing 0.6% phosphate. Upon...
To evaluate the effect of NO added to oxygenator during CPB on liver and kidneys in pigs. Methods . The experiment was conducted 10 pigs undergoing cardiac surgery using cardiopulmonary bypass (CPB). Animals experimental group (CPB-NO; n = 5) received with gas mixture supplied at 100 ppm. control (CPB-control; did not receive via oxygenator. lasted 4 hours followed by 12-hour postoperative monitoring. assess kidney injury, levels alanine aminotransferase (ALT), aspartate (AST), bilirubin,...
The objective of this study was to assess the efficacy a cell-containing wound dressing based on fibroblasts in hydroxyethylcellulose (HEC) gel for local treatment deep partial-thickness and/or full-thickness skin burns an animal model.
Among the problems associated with a new coronavirus infection, possibility of its occurrence in pregnant women plays an important role. Until now, there is very little data on perinatal COVID-19, and are no descriptions structural changes afterbirth at all. Material methods. A clinical morphological analysis 6 cases which verified COVID-19 gave birth infectious hospital was performed. In all cases, placenta examined detail morphologically using antibodies to nucleoprotein spike (S1 subunit...
Overweight and obesity are among the main factors of cardiovascular risk, but prospective studies on dependence between high-fat diets weight gain yielded contradictory results. Different types fats exert varying metabolic effects, this fact leads to a difference in risk associated with increasing body weight. The effects fat quality daily diet immunological status resistance myocardium ischemic-reperfusion damage should be studied experimentally biomedical models. purpose work was assess...
Background. A prompt graft acceptance is essential for positive autologous hematopoietic stem cell transplantation (auto-HSCT) outcome in multiple myeloma patients (MM). Prompt and favourable regeneration associated with CD34+ count a transplant. Although the indicators of low autotransplant cellularity have been defined, practical application new drug products HSC mobilization regimens strengthens relevance determining their influence on transplant quality. Aim. To determine factors that...