A5090091819- Renal Diseases and Glomerulopathies
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Healthcare Systems and Public Health
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Clinical Laboratory Practices and Quality Control
- Parathyroid Disorders and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vitamin D Research Studies
- Dialysis and Renal Disease Management
- Cardiac Ischemia and Reperfusion
- Traditional Chinese Medicine Studies
- Neurological Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- SARS-CoV-2 detection and testing
- Electrochemical sensors and biosensors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pregnancy and Medication Impact
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Chemical and Physical Studies
- Complement system in diseases
- Biosensors and Analytical Detection
First Pavlov State Medical University of St. Petersburg
2017-2024
Abstract Background and Aims The molecular features of idiopathic podocytopathies remain unexplored, preventing the development effective therapies to control mechanisms disease initiation progression. This includes focal segmental glomerulosclerosis (FSGS), one most common forms immune glomerulopathies (IG) cause renal failure replacement therapy. In FSGS, podocytes undergo pronounced cytoskeletal alterations. Along with a decrease in Wilms tumor protein (WT1) α-SMA expression, there is...
ДИСЛИПИДЕМИЯ У ПАЦИЕНТОВ С ТЕРМИНАЛЬНОЙ СТАДИЕЙ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК, НАХОДЯЩИХСЯ НА ПРОГРАММНОМ ГЕМОДИАЛИЗЕАлламова Г
Introduction . Rapid and reliable assessment of circulating antibody levels to SARS-CoV-2 remains the current challenge for monitoring preventing spread COVID-19. As risk emergence dissemination new viral strains continues grow, epidemiologic research is also becomes increasingly important. The enzyme-linked immunosorbent assay (ELISA) useful assess vaccination effectiveness need revaccination, proportion post-disease vaccinated individuals, monitor population immunity. This article provides...
Background : The quality of life (QoL) and the psychological burden immunoglobulin A nephropathy (IgAN) have not been thoroughly studied. Aim To analyze QoL complaints patients with IgAN to test hypothesis that scores are associated clinical demographic variables. Patients methods study included 221 primary IgAN, confirmed by biopsy. None had received immunosuppressive treatment. QOL was assessed using Russian version Kidney Disease Quality Life Short Form (KDQOL-SF) questionnaire, which...
Introduction. Endothelial dysfunction (ED) makes a significant contribution to the pathogenesis of rheumatoid arthritis (RA). However, changes vasomotor function (VF) in patients with reduction disease activity have not been studied enough. Objective – study VF RA and reduce activity, clarify role serological profile presence arterial hypertension (AH) formation dysfunction. Materials methods. A total 94 took part (74 group, 20 comparison group). The longitudinal included 48 10 days interval...
INTRODUCTION. Acute Kidney Injury (AKI) is a common complication of acute coronary syndromes (ACS), and associated with higher mortality adverse outcomes. Despite advances in research over the past years, effective treatments for current AKI are not available. Prevention early intervention remain most strategies any entity. THE AIM: This study aimed to explore risk factors biomarkers predictive diagnostic ACS. PATIENTS AND METHODS. Study was prospective cohort, patients hospitalized ACS...
Background . Endothelial dysfunction (ED) involved in the pathogenesis of rheumatoid arthritis (RA) is more associated with endothelial glycocalyx (EGC) condition. EGC thinning an independent predictor cardiovascular complications that why it important to determine risk factors (RF) most affect RA. Objective To study relationship between endothelium condition and RF for RA unfavourable course (CVR). Design methods The 103 patients aged 18 69 years both sexes active A dark-field microscope...
INTRODUCTION . From 15 to 35% of cases acute coronary syndrome (ACS) are complicated by the development kidney injury (AKI), prevention and early intervention remain most effective strategy for managing patients with AKI in ACS. THE AIM: This study aimed explore a risk factors biomarkers predictive diagnostic PATIENTS AND METHODS The included hospitalized diagnosis ACS Pavlov First Saint Petersburg State Medical University. In case exclusion ACS, were determined comparison group,...
BACKGROUND: Endothelial glycocalyx has an important role in the regulation of endothelial functioning. It is first to be damaged during development autoimmune inflammatory diseases. Thinning leads a violation barrier function blood vessels, and maintenance process. In this context, using assessment for diagnostic monitoring diseases considered great interest.
 AIM: To establish relationship between thickness with activity, serological profile risk factors unfavorable course rheumatoid...
THE AIM. To evaluate the effect of sodium-glucose cotransporter SGLT-2 inhibitor - empagliflozin on kidney in nondiabetic Wistar rats with experimental heart failure (HF). MATERIAL AND METHODS . Cronic (CHF) was induced by ligation left coronary artery. Animals CHF first group (n=11) received (Jardiance®, Boehringer Ingelheim) orally (1 mg / kg/day) for 1 month. In second (n = 10) drug is not administered. Systolic blood pressure, rate, concentrations and daily urinary excretion glucose,...
Abstract Background and Aims Assessment of factors associated with cardiopulmonary bypass (CPB) in acute renal dysfunction patients the early postoperative period after cardiac surgery. Method Monocentric observational study (n = 97) who underwent elective open-heart surgery (coronary artery grafting -50.44%, aortic valve prosthetics - 31.04%, mitral 12.61%) using bypass. Inclusion criteria: included not younger than 18 years old, undergoing CPB lasting up to 95 minutes surgery,...
Abstract Background and Aims Acute Kidney Injury (AKI) is a common complication of acute coronary syndromes (ACS), associated with higher mortality adverse outcomes. Despite advances in research over the past years, effective treatments for current AKI are not available. Prevention early intervention remain most strategies any entity. This study aimed to explore risk factors biomarkers predictive diagnostic ACS. Method Study was prospective cohort, patients hospitalized ACS Pavlov First...
THE AIM . Comparison of indirect immunofluorescence (IIFT) and enzyme-linked immunosorbent assay (ELISA) methods for the determination circulating antibodies to podocytic transmembrane receptor M-type secreted phospholipase A 2 (PLA R-AB) in patients with primary membranous nephropathy (PMN). PATIENTS AND METHODS The study included 54 PMN (M: F [33:21]) aged 55 (40-63) years 10 apparently healthy individuals corresponding gender age. Proteinuria glomerular filtration rate (eGFR) was...
Abstract BACKGROUND AND AIMS Cases of microangiopathy associated with COVID-19 are not fully understood. We aimed to clarify in these patients the presence thrombotic (TMA) and decreased ADAMTS13 activity, possible influence factors on kidney lung damage, outcomes. METHOD The study involved 90 viral pneumonia, who were treated at Pavlov First St. Petersburg State Medical University. Patients undergoing plasma transfusion excluded. In addition standard examination, activity was determined...
Abstract Background and Aims According to a recent data the 25-hydroxyvitamin D (25OHD) level is known be reduced in advanced stages of CKD presumably due i) catabolic activity CYP24 damaged tubules ii) increase renal excretion 25OHD/Vitamin binding protein complex. The association 25OHD with different types tubular damage early (1-3) not well investigated. Method cross-sectional study included 100 patients (37 male; age 38 (30-50) yrs.) biopsy proven primary glomerulopathy...
Abstract Background and Aims Antibodies to M-type phospholipase A2 receptor (PLA2R-Ab) are considered be a promising biomarker for laboratory diagnosis of primary membranous nephropathy (PMN) may useful in the evaluation response therapy CKD prognosis. The aim study was compare two immunoassay methods – indirect immunofluorescence (IIF) enzyme (ELISA) determination circulating PLA2R-Ab patients with PMN. Method included 54 aged 55 (40-63) yrs. (M: F [33:21]) PMN before treatment (n=16)...