A5058221610- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Genetic Syndromes and Imprinting
- Magnesium in Health and Disease
- Vitamin D Research Studies
- Acute Kidney Injury Research
- Cardiovascular Disease and Adiposity
- Electrolyte and hormonal disorders
- Bone health and osteoporosis research
- Healthcare Systems and Public Health
- Birth, Development, and Health
- Apelin-related biomedical research
- Cancer Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Dialysis and Renal Disease Management
- Folate and B Vitamins Research
- Sodium Intake and Health
- Connective Tissue Growth Factor Research
- Bone health and treatments
- Testicular diseases and treatments
- Vasculitis and related conditions
- Renal cell carcinoma treatment
- Atherosclerosis and Cardiovascular Diseases
First Pavlov State Medical University of St. Petersburg
2014-2024
Saint-Petersburg Research Institute of Phthisiopulmonology
2024
Ministry of Health of the Russian Federation
2024
Pavlov Institute of Physiology of the Russian Academy of Sciences
2023
Abstract Extrapulmonary tuberculosis with a renal involvement can be manifestation of disseminated infection that requires therapeutic intervention, particularly decrease in efficacy conventional regimens. In the present study, we investigated potency mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) complex anti-tuberculosis treatment (ATT). A rabbit model (rTB) was constructed by injecting standard strain Mycobacterium H37Rv into cortical layer kidney parenchyma. Isolated...
Arterial hypertension (AH) is associated with heart and chronic kidney disease (CKD). However, the precise mechanisms of myocardial remodeling (MR) in settings CKD remain elusive. We hypothesized that TRPC6, calcineurin/NFAT, Wnt/β-catenin signaling pathways are involved development MR background AH. Early was induced by performing a 5/6 nephrectomy (5/6NE) spontaneously hypertensive rats (SHR-NE). Sham-operated (SO) SHR (SHR-SO) Wistar Kyoto (WKY-SO) served as controls. Systolic blood...
To assess the significance of serum uromodulin (Tamm-Horsfall protein - THP) concentration (Sumo) as an early biomarker tubular atrophy (TA) and interstitial renal fibrosis (IF) in patients with glomerulopathies.84 glomerulopathy 11 practically healthy persons (control) were examined. Uromodulin concentrations urine (Uumo) measured, excretion this estimated glomerular filtration rate (eGFR) established. A semi-quantitative assessment nephrobioptates was performed.Sumo decreases a minimum...
The initial phases of molecular and cellular maladaptive bone responses in early chronic kidney disease (CKD) remain mostly unknown. We induced mild CKD spontaneously hypertensive rats (SHR) by either causing arterial hypertension lasting six months (sham-operated rats, SO6) or its’ combination with 3/4 nephrectomy two (Nx2 Nx6, respectively). Sham-operated SHRs (SO2) Wistar Kyoto (WKY2) a two-month follow-up served as controls. Animals were fed standard chow containing 0.6% phosphate. Upon...
Objective. To assess the expression of leptin gene (LEP) in epicardial (EAT) and subcutaneous (SAT) adipose tissue coronary artery disease (CAD) patients. Methods . 107 people were examined: 87 with CAD (57 men, 30 women), 20 without (10 10 women). Biopsy EAT, SAT, angiography, heart computed tomography, blood levels estimate, mRNA LEP evaluated by PCR. Results. In patients multivessel lesion, level is highest. The EAT higher men than women, non-coronary patients, a multivascular lesion 1–2...
Background. Even a moderate decrease in glomerular filtration rate leads to an increased risk of cardiovascular diseases (CVD), which is the leading cause mortality patients with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) underlies CVD development renal dysfunction. The prevalence LVH CKD stages 2–4 50–70 % and reaches 95 at beginning dialysis, significantly exceeds number cases general population (15–21 %). Common hemodynamic factors associated damage —hypertension...
Background: Initial phases of molecular and cellular maladaptive bone response at early CKD remain mostly unknown. Methods: We induced mild in SHRs by either arterial hypertension lasting six months (sham-operated rats, SO6) or its’ combination with 3/4 nephrectomy two (Nx2 Nx6, correspondently). Sham operated (SO2) Wistar Kyoto rats (WKY2) two-month follow-up served as controls. Animals were fed standard chow containing 0.6% phosphate. measured creatinine clearance, urine...
The relationship between dietary sodium, hypertension, and cardiovascular injury is far from clear. One of the important links in this process can be microRNAs that have ability to modulate gene expression at post-transcriptional level. However, their role has not been fully studied. In addition, further studies require identification structural changes myocardium conditions long-term consumption a high-salt diet.
BACKGROUND. Dietary adjustment is an important point in the treatment of chronic kidney disease (CKD). However, at present, effect a diet with high NaCl content on state cardiovascular system patients early stages CKD has not been sufficiently studied. The AIM: to evaluate blood pressure levels and changes myocardium Wistar rats stage renal dysfunction fed high-salt for long time. MATERIALS AND METHODS: study was performed male rats. control group consisted sham-operated animals (LO-group),...
An evaluation of podocyte's molecular phenotype alterations in primary focal segmental glomerulosclerosis (pFSGS) and IgA nephropathy (IgAN).
Introduction . Rapid and reliable assessment of circulating antibody levels to SARS-CoV-2 remains the current challenge for monitoring preventing spread COVID-19. As risk emergence dissemination new viral strains continues grow, epidemiologic research is also becomes increasingly important. The enzyme-linked immunosorbent assay (ELISA) useful assess vaccination effectiveness need revaccination, proportion post-disease vaccinated individuals, monitor population immunity. This article provides...
The influence of calcium intake during pregnancy on and phosphorus metabolism, bone turnover BMD in postpartum period was investigated 35 healthy pregnant women. control group included 40 women reproductive age. In with the consumption less than 800 mg III trimester there decrease excretion by kidney. both subgroups markers showed increased metabolism tissue 1,3-1,5 times comparison group. Measurement made 4-6 day period. lumbar spine distal forearm osteopenia diagnosed 2,5 1,5 more frequently (p
Excessive salt intake is accompanied by the development of cardiovascular disorders, not always associated with an increase in blood pressure (BP). Given cardioprotective effect soy proteins chronic kidney disease, question arose possibility leveling dietary interventions, particular proteins, damaging a high-salt diet on system. The aim this work to study long-term use high NaCl and protein myocardial remodeling skin histomorphology monkeys. was performed male Javan macaques (Macaca...
Abstract Background and Aims Vascular calcification associated with a maladaptive bone response is common in CKD major cause of mortality (up to 60% depending on stage). Alterations several intracellular signaling pathways have been reported during the cellular phenotype transition vascular calcification, however initial phases remodeling early CKD-MBD remain poorly understood. The aim this study was investigate molecular features aortic prior model mild low turnover. Method We induced by...
Abstract Background and Aims Patients with CKD have significantly increased cardiovascular risk, heart failure is a leading cause of morbidity mortality in these patients. Myocardial hypertrophy hallmark cardiac remodeling dysfunction known to be mediated by angiotensin II, catecholamines, hyperphosphatemia, hyperparathyroidism, increase FGF23, decrease Klotho alterations various signaling pathways including calcineurin, mitogen-activated protein kinase ERK1/2, calmodulin-dependent II etc....
Abstract Background and Aims There is now increased interest in the study of morpho-functional myocardial changes excess NaCl consumption, which develop independently AD dynamics. Myocardial remodeling may involve microRNAs that modulate gene expression at post-transcription level. However, their role this process has not been fully explored. The purpose to assess levels nucleic transcription factor kV (NFkB), microRNA-21 structural myocardium long-term consumption Wistar diet with high (8%)...
Abstract Background and Aims High food intake of NaCl is the traditional factor increase in blood pressure (BP) cardiovascular risks also hurts kidneys. The purpose paper to evaluate morphological changes myocardium normotensive Wistar rats with an early stage renal dysfunction treated a diet increased concentration salt for long time. Method 30 (age 2.5-3 months) were studied divided into three groups 10 each. In first, control, sham-operated (SO) rats, receiving standard (0.34% NaCl),...
Abstract Background and Aims The molecular features of idiopathic podocytopathies remain unexplored, preventing the development effective therapies to control mechanisms disease initiation progression. This includes focal segmental glomerulosclerosis (FSGS), one most common forms immune glomerulopathies (IG) cause renal failure replacement therapy. In FSGS, podocytes undergo pronounced cytoskeletal alterations. Along with a decrease in Wilms tumor protein (WT1) α-SMA expression, there is...
INTRODUCTION. It is suggested that fibroblast growth factor 23 (FGF23) and its co-receptor Klotho are probably associatedwith changes in calcium metabolism chronic kidney disease (CKD) due to ability regulate intracellular Ca transport bymodulating the cationic channels TRPV5 TRPV6. THE AIM investigate association between Klotho, FGF23 renal excretion of initial stages experimental CKD. MATERIAL AND METHODS. The models injury were resection tissue spontaneously hypertensive rats (SHR). Serum...
BACKGROUND. The molecular mechanisms of the initial stages inorganic phosphate (Pi) metabolic disorders in chronic kidney disease (CKD) remain poorly understood. THE AIM. To test hypothesis about changes canonical Wnt signaling pathway inhibitors biosynthesis and a concomitant decrease bone turnover as one early Pi imbalance CKD. MATERIAL AND METHODS. Creatinine (Cr), (Pi), serum parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), osteoprotegerin (OPG), sclerostin (SOST)...
The aim of this study was to analyze the course osteoporosis in elderly females with pulmonary diseases. Methods . involved postmenopausal who did not receive regular treatment oral steroids. All patients underwent spirometry before and after inhalation a bronchodilator, bone densitometry assessment mineral density (BMD) T-score at proximal thigh, lumbal spine one third distal forearm. FRAX risk score also used. Results We examined 79 (mean age, 66.9 ± 1.7 years). Female chronic obstructive...