Arterial hypertension (AH) is associated with heart and chronic kidney disease (CKD). However, the precise mechanisms of myocardial remodeling (MR) in settings CKD remain elusive. We hypothesized that TRPC6, calcineurin/NFAT, Wnt/β-catenin signaling pathways are involved development MR background AH. Early was induced by performing a 5/6 nephrectomy (5/6NE) spontaneously hypertensive rats (SHR-NE). Sham-operated (SO) SHR (SHR-SO) Wistar Kyoto (WKY-SO) served as controls. Systolic blood...

B ackground . Cardiovascular complications are common in chronic kidney disease (CKD). The relationship between the cardiovascular system and kidneys is complex diverse, but question of mechanisms influence excess NaCl consumption on functional state blood vessels during renal dysfunction remains relevant. aim : to evaluate effect a high-salt diet microcirculatory (MCR) skin rats at an early stage dysfunction. Material Methods study was conducted Wistar rats. first SO group included animals...

The initial phases of molecular and cellular maladaptive bone responses in early chronic kidney disease (CKD) remain mostly unknown. We induced mild CKD spontaneously hypertensive rats (SHR) by either causing arterial hypertension lasting six months (sham-operated rats, SO6) or its’ combination with 3/4 nephrectomy two (Nx2 Nx6, respectively). Sham-operated SHRs (SO2) Wistar Kyoto (WKY2) a two-month follow-up served as controls. Animals were fed standard chow containing 0.6% phosphate. Upon...

BACKGROUND . Increased salt intake is associated with a number of cardiovascular events, including increased blood pressure (BP) and the development left ventricular hypertrophy (LVH). However, there much evidence that high content sodium chloride in diet does not always lead to an increase BP, but almost inevitably causes cardiac remodeling, particular, LVH. Many aspects myocardial remodeling induced by food have been studied enough. THE AIM study was trace echocardiographic changes Wistar...

The aim : to evaluate changes in endothelium-dependent regulation of the tone blood vessels (aorta and superior mesenteric artery) rats 4 months after removal 5/6 renal tissue. Material methods. An experimental CKD model was created by resection mass group included animals (n = 12), subjected nephrectomy (NE). control consisted sham-operated (SO) 10). Researches vascular reactivity were performed on ring segments 2 mm long, which excised from aorta artery (SMA). A total 23 17 SMA NE 18 15...

BACKGROUND. Modeling of chronic kidney disease using nephrectomy 5/6 parenchyma is actively used in experimental nephrology. However, the remaining 17 % organ associated with severe renal fibrosis humans. A high-salt diet has traditionally been considered as a systemic hemodynamic model for development disease. THE AIM : to compare functional disorders that occur rats ¾ kidneys and when only diet. MATERIAL AND METHODS . The study was performed on 30 male Wistar rats. animals were randomly...

The aim of the study - to evaluate effects age and renal dysfunction on myocardium coronary vessels in young Wistar rats. Materials methods. was performed male rats aged ~ 2.5 months. 5/6 nephrectomy (NE) stepwise at intervals one week. observation period 2 or 4 months after NE sham operation. For histological examination, heart sections were stained with hematoxylin & eosin by van Gieson. changes studied light microscopy quantitatively assessed morphometry program Videotest 5.2. Results. At...

High food intake of sodium chloride is associated with damage not only the cardiovascular system, but also kidneys. The mechanisms potential negative effects high-salt diets on kidneys have been established. aim study was to trace changes in relative expression miRNA-21, 203 and 133 urine cynomolgus macaques (Macaca fascicularis) fed diet without isolated soy proteins. Material methods. object 18 male aged 6-8 years a body weight 5.1-9.7 kg. animals were divided 3 groups (6 individuals...

Background. Even a moderate decrease in glomerular filtration rate leads to an increased risk of cardiovascular diseases (CVD), which is the leading cause mortality patients with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) underlies CVD development renal dysfunction. The prevalence LVH CKD stages 2–4 50–70 % and reaches 95 at beginning dialysis, significantly exceeds number cases general population (15–21 %). Common hemodynamic factors associated damage —hypertension...

The effect of nephrectomy on the Wistar Kyoto rat superior mesenteric artery (SMA) and internal carotid (ICA) segments constriction dilatation ability was studied under isometric conditions using myograph. 5/6 (5/6 Nx) in rats 3 months old used as a model chronic kidney disease. Dilatation phenylephrine-precontracted induced by acetylcholine (AСh) or sodium nitroprusside (SNP) absence presence potassium channels blockers (tetraethylammonium, glibenclamide) methylene blue, guanylyl-cyclase...

The relationship between dietary sodium, hypertension, and cardiovascular injury is far from clear. One of the important links in this process can be microRNAs that have ability to modulate gene expression at post-transcriptional level. However, their role has not been fully studied. In addition, further studies require identification structural changes myocardium conditions long-term consumption a high-salt diet.

The aim : to evaluate functional and structural changes in blood vessels myocardium Wistar rats at different stages of the formation experimental kidney dysfunction. Materials Methods . Four groups animals were studied. first two consisted subjected 5/6 nephrectomy (NE). period after NE is 2 or 4 months. third fourth included sham-operated (SO) a similar observation period. After end experiment, pressure was measured rats, left ventricular mass index (LVMI) calculated, biochemical test,...

The renin-angiotensin-aldosterone system (RAAS) is involved in the regulation of kidney function and blood pressure (BP). In renal dysfunction, hyperactivation RAAS leads to an increase BP impaired permeability nephron glomerular filter. Blockade one methods nephroprotection. Objective . To compare effect angiotensin-converting enzyme inhibitor (IACE), angiotensin I receptor blocker (ARB), a selective slow calcium channel (BCC) on functional state microvasculature skin rats with nephrectomy...

The aim. To assess the effect of enrichment calcium and magnesium in drinking water on level arterial pressure (BP), myocardial remodeling processes, autorhythmic contractile activity portal vein (PV) spontaneously hypertensive SHR rats control WKY rats. Material methods . One group received enriched with (120 mg/L) (45 from a 6-week-old age within 2 months. Two other groups St. Petersburg tap low content Са 2+ (8 Mg (3 mg/L). All standard diet. At end observation period, were assessed blood...

Excessive salt intake is accompanied by the development of cardiovascular disorders, not always associated with an increase in blood pressure (BP). Given cardioprotective effect soy proteins chronic kidney disease, question arose possibility leveling dietary interventions, particular proteins, damaging a high-salt diet on system. The aim this work to study long-term use high NaCl and protein myocardial remodeling skin histomorphology monkeys. was performed male Javan macaques (Macaca...

Abstract Background and Aims There is now increased interest in the study of morpho-functional myocardial changes excess NaCl consumption, which develop independently AD dynamics. Myocardial remodeling may involve microRNAs that modulate gene expression at post-transcription level. However, their role this process has not been fully explored. The purpose to assess levels nucleic transcription factor kV (NFkB), microRNA-21 structural myocardium long-term consumption Wistar diet with high (8%)...