David P. Lee
A5019551821- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Esophageal and GI Pathology
- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Migraine and Headache Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Transplantation: Methods and Outcomes
- Gastroesophageal reflux and treatments
- Cardiovascular Disease and Adiposity
- Esophageal Cancer Research and Treatment
- Cardiac Structural Anomalies and Repair
- Gastrointestinal disorders and treatments
- HIV/AIDS Research and Interventions
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Cardiovascular Effects of Exercise
- Liver Disease and Transplantation
Charles R. Drew University of Medicine and Science
2017-2025
APLA Health
2025
Stanford Health Care
2014-2024
University of California, Irvine
2018-2023
Stanford University
2011-2023
Methodist Dallas Medical Center
2020-2023
University of California, Irvine Medical Center
2019-2021
Cardiovascular Institute of the South
2015-2020
Stanford Medicine
2005-2018
OASIS Clinic
2017
Dual antiplatelet therapy is recommended after coronary stenting to prevent thrombotic complications, yet the benefits and risks of treatment beyond 1 year are uncertain.Patients were enrolled they had undergone a stent procedure in which drug-eluting was placed. After 12 months with thienopyridine drug (clopidogrel or prasugrel) aspirin, patients randomly assigned continue receiving receive placebo for another 18 months; all continued aspirin. The coprimary efficacy end points thrombosis...
The purpose of this document is to make the output International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available medical scientific communities, through a peer-reviewed publication, in interest improving diagnosis treatment patients with atherosclerosis, including coronary artery disease. optical coherence tomography (IVOCT) catheter-based modality that acquires images at resolution ∼10 μm, enabling visualization blood vessel...
The SYMPLICITY HTN-3 randomized, blinded, sham-controlled trial confirmed the safety of renal denervation (RDN), but did not meet its primary efficacy endpoint. Prior RDN studies have demonstrated significant and durable reductions in blood pressure. This analysis investigated factors that may help explain these disparate results. Patients with resistant hypertension were randomized 2 : 1 to (n = 364) or sham 171). endpoint was difference office systolic pressure (SBP) change at 6 months. A...
Background— More than 20% of patients presenting to the cardiac catheterization laboratory with angina have no angiographic evidence coronary artery disease. Despite a “normal” angiogram, these often persistent symptoms, recurrent hospitalizations, poor functional status, and adverse cardiovascular outcomes, without clear diagnosis. Methods Results— In 139 in absence obstructive disease (no diameter stenosis >50%), endothelial function was assessed; index microcirculatory resistance, flow...
Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension the absence of antihypertensive medications.
Previous work has suggested that platelet glycoprotein IIb/IIIa receptor blockade may confer benefit in the treatment of acute myocardial infarction. The TIGER-PA pilot trial was a single-center randomized study to evaluate safety, feasibility, and utility early tirofiban administration before planned primary angioplasty patients presenting with infarction.A total 100 infarction were either emergency room or later catheterization laboratory. outcome measures initial TIMI grade flow,...
<h3>Importance</h3> Despite antirestenotic efficacy of coronary drug-eluting stents (DES) compared with bare metal (BMS), the relative risk stent thrombosis and adverse cardiovascular events is unclear. Although dual antiplatelet therapy (DAPT) beyond 1 year provides ischemic event protection after DES, perceived to be less BMS, appropriate duration DAPT BMS unknown. <h3>Objective</h3> To compare (1) rates major cardiac cerebrovascular (MACCE; composite death, myocardial infarction, or...
The TAXUS Liberté Post Approval Study (TL-PAS) contributed patients treated with paclitaxel-eluting stent and prasugrel to the Dual Antiplatelet Therapy (DAPT) that compared 12 30 months thienopyridine plus aspirin therapy after drug-eluting stents.Outcomes for 2191 TL-PAS enrolled into DAPT were assessed. coprimary composite end point (death, myocardial infarction [MI], or stroke) was lower treatment (3.7% versus 8.8%; hazard ratio [HR], 0.407; P<0.001). Rates of death stroke similar...
Tenofovir disoproxil fumarate/emtricitabine preexposure prophylaxis (PrEP) is effective against HIV acquisition when taken as prescribed. Strategies that identify and intervene with those challenged by adherence to daily medication are needed.PATH-PrEP was an open-label single-arm interventional cohort study conducted at 2 community-based clinical sites in Los Angeles, CA.We enrolled self-identified men who have sex transgender women ≥18 years of age elevated risk acquisition. Participants...
<b>Background</b> Treatment of Zenker's diverticulum has evolved from open surgery to endoscopic techniques, including flexible and rigid septotomy, more recently, peroral myotomy (Z-POEM). This study compared the effectiveness septotomy with that Z-POEM. <b>Methods</b> Consecutive patients who underwent (flexible/rigid) or Z-POEM for between 1/2016 9/2019 were included. Primary outcomes clinical success (decrease in Dakkak Bennett dysphagia score ≤ 1), failure, recurrence. Secondary...
INTRODUCTION: Cholecystectomy (CCY) is the gold standard treatment of acute cholecystitis (AC). Nonsurgical management AC includes percutaneous transhepatic gallbladder drainage (PT-GBD) and endoscopic ultrasound-guided (EUS-GBD). This study aims to compare outcomes patients who undergo CCY after having received EUS-GBD vs PT-GBD. METHODS: A multicenter international was conducted in with underwent or PT-GBD, followed by an attempted CCY, between January 2018 October 2021. Demographics,...
The utility of measuring fractional flow reserve (FFR) to assess cardiac transplant arteriopathy has not been evaluated. Measuring coronary (CFR) as well FFR could add information about the microcirculation, but until recently, this required two wires. We evaluated a new method for simultaneously and CFR with single wire investigate arteriopathy.In 53 cases asymptomatic recipients without angiographically significant disease, thermodilution-derived (CFRthermo) were measured same pressure in...
Patients with diabetes mellitus (DM) are at high risk for recurrent ischemic events after coronary stenting. We assessed the effects of continued thienopyridine among patients DM participating in Dual Antiplatelet Therapy (DAPT) Study as a prespecified analysis.After stent placement and 12 months treatment open-label plus aspirin, 11 648 free or bleeding who were medication compliant randomly assigned to placebo, addition 18 more months. After randomization, (n=3391), comparison without...