A5011483450- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Inflammation biomarkers and pathways
- Electrolyte and hormonal disorders
- Dialysis and Renal Disease Management
- Adrenal and Paraganglionic Tumors
- Apelin-related biomedical research
- ATP Synthase and ATPases Research
- 14-3-3 protein interactions
- Renal and related cancers
- Sodium Intake and Health
- Birth, Development, and Health
- Potassium and Related Disorders
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Renal function and acid-base balance
- Renal Transplantation Outcomes and Treatments
- Metabolism, Diabetes, and Cancer
- Genetic Syndromes and Imprinting
- Heart Rate Variability and Autonomic Control
- Magnesium in Health and Disease
Stanford University
2015-2024
Stanford Medicine
2017-2024
Intel (United States)
2023
Washington University in St. Louis
2022
Palo Alto University
2014-2021
RELX Group (United States)
2019
Indiana University
2018
Indiana University School of Medicine
2018
University of California, San Francisco
2005-2006
M. P. Shah Medical College
2005
Cardiorenal syndrome encompasses a spectrum of disorders involving both the heart and kidneys in which acute or chronic dysfunction 1 organ may induce other organ. It represents confluence heart-kidney interactions across several interfaces. These include hemodynamic cross-talk between failing response vice versa, as well alterations neurohormonal markers inflammatory molecular signatures characteristic its clinical phenotypes. The mission this scientific statement is to describe...
Serum- and glucocorticoid-regulated kinase 1 (SGK1) is an aldosterone-regulated early response gene product that regulates the activity of several ion transport proteins, most notably epithelial sodium channel (ENaC). Recent evidence has established SGK1 phosphorylates inhibits Nedd4-2 (neural precursor cell-expressed, developmentally down-regulated protein 4-2), a ubiquitin ligase decreases cell surface expression possibly stimulates its degradation. The mechanistic basis for this...
Resistant hypertension is associated with higher rates of cardiovascular disease, kidney and death than primary hypertension. Although clinical practice guidelines recommend screening for aldosteronism among persons resistant hypertension, are unknown. We identified 145 670 excluded congestive heart failure or advanced chronic disease. Among this cohort, we studied 4660 ages 18 to <90 from the years 2008 2014 available laboratory tests within following 24 months. The rate in was 2.1%....
Primary aldosteronism is a common cause of treatment-resistant hypertension. However, evidence from local health systems suggests low rates testing for primary aldosteronism.To evaluate and evidence-based hypertension management in patients with hypertension.Retrospective cohort study.U.S. Veterans Health Administration.Veterans apparent (n = 269 010) 2000 to 2017, defined as either 2 blood pressures (BPs) at least 140 mm Hg (systolic) or 90 (diastolic) 1 month apart during use 3...
There has been much speculation in journals, as well social and traditional media about a link between popularly used classes of drugs that inhibit the renin-angiotensin system (RAS) novel coronavirus (severe acute respiratory syndrome 2 [SARS-CoV-2]) infection or disease 2019 (COVID-19) severity (1,2). After examining available evidence, we advise inhibitors RAS pathway should be continued patients with COVID-19 who are taking these for evidence-based indications. The putative SARS-CoV-2...
We recently found that the metabolic sensor AMP-activated kinase (AMPK) inhibits epithelial Na+ channel (ENaC) through decreased plasma membrane ENaC expression, an effect requiring presence of a binding motif in cytoplasmic tail beta-ENaC subunit for ubiquitin ligase Nedd4-2. To further examine role Nedd4-2 regulation by AMPK, we studied effects AMPK activation on currents Xenopus oocytes co-expressing and wild-type (WT) or mutant forms inhibition was preserved expressing WT but blocked...
To examine racial/ethnic differences in the prevalence of diabetic kidney disease (DKD), with and without proteinuria, an outpatient health care organization.We examined electronic records for 15,683 persons non-Hispanic white (NHW), Asian (Asian Indian, Chinese, Filipino), Hispanic, black (NHB) race/ethnicity type 2 diabetes no prior history from 2008 to 2010. We directly standardized age- sex-adjusted rates proteinuric DKD (proteinuria or low estimated glomerular filtration rate [eGFR])...
Background: Blood lead levels (BLLs) less than 1.21 µmol/L (<25 µg/dL) among adults are considered acceptable by current national standards. Lead toxicity can to gouty arthritis (gout), but whether the low exposure in contemporary general population confers risk for gout is not known. Objective: To determine BLLs within range currently associated with gout. Design: Population-based cross-sectional study. Setting: The National Health and Nutrition Examination Survey 2005 through 2008....
Hypertension Hot Potato A spate of recalls angiotensin-receptor blockers highlights several issues related to the readiness our health systems respond drug recalls, trust between patients and providers, uncertain drug-dose equivalences, regulation manufacturing in global marketplace.
Urinary biomarkers are associated with cardiovascular disease, but the nature of these associations is not well understood. We performed multivariable-adjusted regression models to assess random spot measurements urine sodium-potassium ratio (UNa/UK) and albumin adjusted for creatinine risk factors, type 2 diabetes mellitus (T2D) in 478 311 participants UK Biobank. Further, we assessed causal relationships kidney biomarkers, used as proxies function, outcomes using 2-sample Mendelian...
Background High blood pressure affects approximately 116 million adults in the United States. It is leading risk factor for death and disability across world. Unfortunately, over past decade, hypertension control rates have decreased Prediction models clinical studies shown that reducing clinician inertia alone sufficient to reach target of ≥80% control. Digital health tools containing evidence‐based algorithms are able reduce a good fit turning tide control, but careful consideration should...
Background. Histologic findings of diabetic nephropathy (DN) are observed in allografts patients with pretransplant (PreTx) diabetes mellitus (DM) and who develop DM posttransplant (PostTx). Patients allograft biopsies (Bx) were retrospectively studied to determine the incidence recurrent de novo DN ascertain what, if any, risk factors predispose histologic either patient population. Methods. From renal transplant services at four hospitals from 1992 2000, authors identified all PreTxDM...
Regulation of epithelial Na+ channel (ENaC)-mediated transport in the distal nephron is a critical determinant blood pressure humans. Aldosterone via serum and glucocorticoid kinase 1 (SGK1) stimulates ENaC by phosphorylation E3 ubiquitin ligase Nedd4-2, which induces interaction with 14-3-3 proteins. However, mechanisms SGK1- 14-3-3-mediated regulation Nedd4-2 are unclear. There three canonical SGK1 target sites on that overlap phosphorylation-dependent motifs. Two these termed "minor," one...
A kidney disease of unknown cause is common in Sri Lanka's lowland (dry) region. Detailed clinical characterizations patients with biopsy-proven are limited, and there no current consensus on criteria for a noninvasive diagnosis.