A5007274377- Photoacoustic and Ultrasonic Imaging
- Coronary Interventions and Diagnostics
- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Optical Coherence Tomography Applications
- Advanced MRI Techniques and Applications
- Ultrasound and Cavitation Phenomena
- Elasticity and Material Modeling
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Ultrasonics and Acoustic Wave Propagation
- Optical Imaging and Spectroscopy Techniques
- Medical Image Segmentation Techniques
- Electrical and Bioimpedance Tomography
- Thermography and Photoacoustic Techniques
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Advanced X-ray and CT Imaging
- Angiogenesis and VEGF in Cancer
- Acute Ischemic Stroke Management
- Atherosclerosis and Cardiovascular Diseases
Erasmus MC
2016-2025
Shenzhen Institutes of Advanced Technology
2014-2024
Delft University of Technology
2015-2024
Erasmus University Rotterdam
2014-2023
Chinese Academy of Sciences
2014-2022
Netherlands Heart Institute
2009-2021
University Medical Center
2021
Rotterdam University of Applied Sciences
2006-2020
Battelle
2019
Cancer Services
2016
The purpose of this document is to make the output International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available medical scientific communities, through a peer-reviewed publication, in interest improving diagnosis treatment patients with atherosclerosis, including coronary artery disease. optical coherence tomography (IVOCT) catheter-based modality that acquires images at resolution ∼10 μm, enabling visualization blood vessel...
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is expressed abundantly in the necrotic core of coronary lesions, and products its enzymatic activity may contribute to inflammation cell death, rendering plaque vulnerable rupture.This study compared effects 12 months treatment with darapladib (an oral Lp-PLA(2) inhibitor, 160 mg daily) or placebo on atheroma deformability (intravascular ultrasound palpography) plasma high-sensitivity C-reactive protein 330 patients angiographically...
We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh arteries ex vivo, showing different stages disease. A 1.25 mm diameter catheter built, comprising an angle-polished optical fiber adjacent to a 30 MHz ultrasound transducer. Specific lipid content, key factor in vulnerable plaques that may lead myocardial infarction, is achieved by spectroscopic at wavelengths between 1180 and 1230 nm. Simultaneous with performed.
Despite advanced understanding of the biology atherosclerosis, coronary heart disease remains leading cause death worldwide. Progress has been challenging as half individuals who suffer sudden cardiac do not experience premonitory symptoms. Furthermore, it is well-recognized that also a plaque does haemodynamically significant stenosis can trigger event, yet majority ruptured or eroded plaques remain clinically silent. In past 30 years since term 'vulnerable plaque' was introduced, there...
BACKGROUND Patients with symptomatic carotid stenosis are at high risk for recurrent stroke.The decision endarterectomy currently mainly relies on degree of (cutoff value >50% or 70%).Nevertheless, also, patients mild-to-moderate still have a considerable stroke risk.Increasing evidence suggests that plaque composition rather than determines vulnerability; however, it remains unclear whether this also provides additional information to improve clinical making.OBJECTIVES The PARISK (Plaque At...
Spectroscopic intravascular photoacoustic imaging (sIVPA) has shown promise to detect and distinguish lipids in atherosclerotic plaques. sIVPA generally utilizes one of the two high absorption bands lipid spectrum at 1.2 μm 1.7 μm. Specific signatures various compounds within either wavelength range can potentially be used differentiate between plaque peri-adventitial lipids. With aim quantify any differences bands, we performed combined both on a vessel phantom an human coronary artery ex...
Patient specific geometrical data on human coronary arteries can be reliably obtained multislice computer tomography (MSCT) imaging. MSCT cannot provide hemodynamic variables, and the outflow through side branches must estimated. The impact of two different models to determine flow wall shear stress (WSS) distribution in patient geometries is evaluated. Murray's law predicts that ratio scales with diameter third power. empirical model based measurements performed by Doriot et al. (2000)...
We demonstrate intravascular optical coherence tomography (OCT) imaging with frame rate up to 3.2 kHz (192,000 rpm scanning). This was achieved by using a custom-built catheter in which the circumferential scanning actuated 1.0 mm diameter synchronous motor. The OCT system, an depth of 3.7 (in air), is based on Fourier domain mode locked laser operating at A-line 1.6 MHz. 1.1 tip. Ex vivo images human coronary artery (78.4 length) were acquired pullback speed 100 mm/s. True 3D volumetric...
Background and aimsCarotid artery plaques with vulnerable plaque components are related to a higher risk of cerebrovascular accidents. It is unknown which factors drive development. Shear stress, the frictional force blood at vessel wall, known influence formation. We evaluated association between shear stress (intraplaque haemorrhage (IPH), lipid rich necrotic core (LRNC) and/or calcifications) in relatively small carotid asymptomatic persons.MethodsParticipants (n = 74) from...
Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations IV-OCT can be addressed by using an imaging system that called "Heartbeat OCT", combining a fast Fourier Domain Mode Locked laser, pullback, micromotor actuated catheter, designed to examine coronary vessel in less than one cardiac cycle. We acquired vivo data sets...
Abstract Aims Atherosclerotic plaque development has been associated with wall shear stress (WSS). However, the multidirectionality of blood flow, and thus WSS, is rarely taken into account. The purpose this study was to comprehensively compare five metrics that describe (multidirectional) WSS behaviour assess how affects coronary initiation progression. Methods results Adult familial hypercholesterolaemic pigs (n = 10) were fed a high-fat diet, underwent imaging three main arteries at...
Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging.To date, the clinical translation of IVPA/US imaging has been stalled by a low speed and catheter complexity.In this paper, we demonstrate lipid targets in swine coronary arteries vivo, at clinically useful frame rate 20 s -1 .We confirmed image contrast for atherosclerotic plaque human samples ex vivo.The system is on mobile platform provides real-time data visualization during...
Oncological neurosurgery relies heavily on making continuous, intra-operative tumor-brain delineations based image-guidance. Limitations of currently available imaging techniques call for the development real-time image-guided resection tools, which allow reliable functional and anatomical information in an setting. Functional ultrasound (fUS), is a new mobile neuro-imaging tool with unprecedented spatiotemporal resolution, allows detection small changes blood dynamics that reflect metabolic...
Coronary atherosclerosis is caused by plaque build-up, with lipids playing a pivotal role in its progression. However, lipid composition and distribution within coronary remain unknown. This study aims to characterize investigate differences across disease stages aid the understanding of Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was used visualize distributions artery sections (n=17) from hypercholesterolemic swine. We performed histology on...
Rupture of thin-cap fibroatheromatous plaques is a major cause acute myocardial infarction (AMI). Such can be identified in vitro by 3D intravascular palpography with high sensitivity and specificity. We used this technique patients undergoing percutaneous intervention to assess the incidence mechanically deformable regions. further explored relation such regions clinical presentation C-reactive protein levels.Three-dimensional palpograms were derived from continuous ultrasound pullbacks....