A5042801299- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Global Health Care Issues
- Acute Kidney Injury Research
- Liver Disease and Transplantation
- Healthcare Policy and Management
- Diabetes Treatment and Management
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Biomedical Research and Pathophysiology
- Pediatric Urology and Nephrology Studies
- Potassium and Related Disorders
- Healthcare cost, quality, practices
- Renal Transplantation Outcomes and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Adolescent and Pediatric Healthcare
- Abdominal Trauma and Injuries
- COVID-19 epidemiological studies
- Palliative Care and End-of-Life Issues
- Renal function and acid-base balance
- Parathyroid Disorders and Treatments
Aberdeen Royal Infirmary
2017-2025
NHS Grampian
2022
Southmead Hospital
2013-2018
Renal Association
2016-2018
University of Bristol
2013-2017
North Bristol NHS Trust
2015-2017
Royal Preston Hospital
2015
University of Glasgow
2013
Western Infirmary
2013
University Hospital Crosshouse
2010-2011
Patients with kidney failure requiring KRT are at high risk of complications and death following SARS-CoV-2 infection, variable antibody responses to vaccination reported. We investigated the effects COVID-19 on incidence hospitalization, from infection.
International consensus supports the development of standardized mGFR protocols to facilitate implementation more widespread and routine testing in clinical care research protocols. With support from EKFC, an international group experts performed extensive literature search develop recommendations for a approach determine mGFR. This paper evaluated evidence formulated that include all aspects iohexol plasma clearance measurement adults not on dialysis. These practical advice patient...
Background. Quantification of proteinuria is important in the assessment chronic kidney disease (CKD). The aim this study was to investigate optimal test identify significant proteinuria. Methods. We retrospectively assessed relationship between total protein:creatinine ratio (TPCR), albumin:creatinine (ACR) and 24-h urine protein 6842 patients with CKD focusing on performance at thresholds 0.5 1 g/day Results. ACR TPCR non-linear. highly correlated (Spearman's ρ = 0.91), though also...
Infection with the severe acute respiratory coronavirus 2 (SARS-CoV-2) has led to a worldwide pandemic disease 2019 (COVID-19), caused by SARS-CoV-2, overwhelming healthcare systems globally. Preliminary reports suggest high incidence of infection and mortality SARS-CoV-2 in patients receiving kidney replacement therapy (KRT). The aims this study are report characteristics, rates outcomes all affected undergoing KRT Scotland.Study design was an observational cohort study. Data were linked...
ABSTRACT Background The aim of this study was to describe the trends in incidence, prevalence and survival patients on kidney replacement therapy (KRT) for end-stage disease (ESKD) across Europe from 2008 2017. Methods Data renal registries 9 countries 16 regions that provided individual patient data ERA Registry 2017 were included. These cover 34% general population Europe. Crude standardized incidence per million (pmp) determined. Trends over time studied using Joinpoint regression....
Causes of death .Comorbidity .Dialysis .End stage renal disease (ESRD) .Established failure (ERF) .Haemodialysis .Outcome .Peritoneal dialysis .Renal replacement therapy (RRT) .Survival .Transplant .Vintage Summary .Short-term (90 day) age-adjusted survival incident RRT patients in 2014 was static compared with 2013 (96.8% versus 96.9%). .One year after 90 day age adjusted for the cohort fell slightly to 90.2% previous (91.4%). .There a difference one by group and diagnosis diabetes:...
Chronic kidney disease (CKD) is a global health burden, yet it still underrepresented within public agendas in many countries. Studies focusing on the natural history of CKD are challenging to design and conduct, because long time-course progression, wide variation etiologies, large amount clinical variability among individuals with CKD. With difference health-related behaviors, healthcare delivery, genetics, environmental exposures, this greater across countries than one locale may not be...
Proteinuria predicts poor renal and cardiovascular outcomes. Some guidelines recommend measuring proteinuria using albumin:creatinine ratio (ACR), while others total protein:creatinine (TPCR).To compare outcomes mortality in the populations identified by these different recommendations.Retrospective longitudinal cohort study.Baseline ACR TPCR measurements were obtained from 5586 patients with chronic kidney disease (CKD) attending a Scottish hospital nephrology clinic. The was divided into...
Abstract Background and hypothesis Knowledge regarding access to first kidney transplantation (KT) subsequent KT in patients commencing replacement therapy (KRT) childhood is limited. Methods Using European Renal Association (ERA) Registry data, we investigated who started KRT below 20 years of age between 1978 2019. Access determinants first, second third were assessed using multivariable Cox regression. Results 12 623, 4077, 1186 included while awaiting KT, at median ages 13.8 (IQR:...
Abstract With the aim to expand randomized controlled trial evidence of cinacalcet treatment unselected, general chronic kidney disease (CKD) population we analysed a large inception cohort CKD patients in region Stockholm, Sweden 2006–2012 (both non-dialysis, dialysis and transplanted) with secondary hyperparathyroidism (SHPT). We used marginal structural models account for both confounding by indication time-dependent confounding. Over 37 months, 435/3,526 (12%) initiated de novo . Before...
Introduction: Most UK laboratories use the MDRD4 formula to estimate glomerular filtration rate (eGFR), but this may exaggerate chronic kidney disease (CKD) prevalence. In a large adult population, we examined impact of more accurate CKD-EPI formulae on prevalence estimates, and secular trends in Methods: We extracted all serum creatinine (SCr) results for adults, processed our laboratory during two 1-year periods (2004, 2009–10). To minimize effect acute illness, patient's lowest SCr was...
ABSTRACT Background No single study contrasts the extent and consequences of inequity kidney care across clinical course disease. Methods This population Grampian (UK) followed incident presentations acute injury (AKI) estimated glomerular filtration rate (eGFR) thresholds <60, <45 <30 mL/min/1.73 m2 in separate cohorts (2011–2021). The key exposure was area-level deprivation (lowest quintile Scottish Index Multiple Deprivation). Outcomes were processes (monitoring,...
Patients who start renal replacement therapy (RRT) for End-Stage Kidney Disease (ESKD) without having had timely access to specialist services have poor outcomes. At one NHS Trust in England, a community-wide CKD management system has led decline the incident rate of RRT and lowest percentage patients presenting within 90 days starting UK. We describe protocol quality improvement project scale up evaluate this innovation. The intervention is based upon an off-line database that integrates...
Primary care chronic kidney disease (CKD) registers report widely varying prevalence within the UK. We examined effects of laboratory ascertainment and adjusting for practice-level variables on variation in CKD prevalence. carried out an Ayrshire-wide database analysis primary practices (PCPs). analysed 54 PCPs with 313 639 registered patients aged ≥18. All a low estimated glomerular filtration rate (<60 mL/min/1.73 m2) had their serum creatinine values extracted from 1st January 2009 to...
ABSTRACT Background Inherited kidney diseases (IKDs) and congenital anomalies of the urinary tract (CAKUT) are causes failure requiring replacement therapy (KRT) that major renal registries usually amalgamate into primary disease(PRD) category ‘miscellaneous’ or in glomerulonephritis pyelonephritis categories. This makes IKDs invisible (except for polycystic disease) may negatively influence use genetic testing, which identify a cause some CAKUT. Methods We re-examined aetiology KRT by...
Objective To explore dialysis decision-making for adults who lack capacity due to cognitive impairment, a common and under-recognised condition in those with advanced chronic kidney disease (CKD). Design Secondary analysis of qualitative data collected during the Conservative Kidney Management Assessment Practice Patterns Study programme research was performed. Sixty semistructured interviews were conducted multiprofessional team members from UK renal centres. Staff asked about local...
Proteinuria is associated with poorer outcomes in renal transplant recipients. Fractional excretion of total protein (FEPR) may better reflect kidney damage than urine protein-to-creatinine ratio (PCR).We assessed FEPR (FEPR = [serum creatinine × protein] / creatinine], %) and PCR ([urinary protein/urinary creatinine] 1000, mg/mM) 1 year after first transplantation as predictors failure. The primary endpoints were failure death. use the tests was analyzed by constructing receiver operator...