A5032271799- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Malaria Research and Control
- Pharmaceutical Quality and Counterfeiting
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- American Environmental and Regional History
- CAR-T cell therapy research
- Lung Cancer Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Cancer, Lipids, and Metabolism
- Pharmaceutical Economics and Policy
- Law, Economics, and Judicial Systems
- Archaeology and Natural History
- interferon and immune responses
- Immune cells in cancer
- Cancer Treatment and Pharmacology
- Prostate Cancer Treatment and Research
- Lung Cancer Research Studies
- PARP inhibition in cancer therapy
- Mosquito-borne diseases and control
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
University of Michigan
2016-2025
VA Ann Arbor Healthcare System
2020-2025
Centers for Disease Control and Prevention
2010-2025
University of Pittsburgh
1993-2025
Scottish Power (United Kingdom)
2025
Michigan Medicine
2019-2024
Children's Hospital of Pittsburgh
1993-2024
Ann Arbor VA Medical Center
2024
U-M Rogel Cancer Center
2021-2024
Michigan United
2022-2024
Abstract A challenge in oncology is to rationally and effectively integrate immunotherapy with traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy induces tumor-cell ferroptosis. Ferroptosis agonists augment ferroptosis antagonists limit efficacy tumor models. Immunotherapy sensitizes tumors by promoting Mechanistically, IFNγ derived from immunotherapy-activated CD8+ T cells radiotherapy-activated ATM independently, yet synergistically, suppresses SLC7A11,...
Programmed death-1 ligand (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1) pathway blockade is a promising therapy for treating cancer. However, the mechanistic contribution of host tumor PD-L1 PD-1 signaling to therapeutic efficacy remains elusive. Here, we evaluated 3 tumor-bearing mouse models that differ in their sensitivity demonstrated loss immunodeficient mice PD-L1– PD-1–deficient mice. In contrast, neither knockout nor overexpression cells had an effect on efficacy. Human...
Abstract Combinatorial strategies are needed to overcome the resistance of pancreatic cancer immune checkpoint blockade (ICB). DNA damage activates innate response and improves ICB efficacy. Because ATM is an apical kinase in radiation-induced response, we investigated effects inhibition radiation on tumor immunogenicity. was inhibited through pharmacologic genetic human murine models both vitro vivo. Tumor immunogenicity evaluated after alone combination with by assessing TBK1 Type I...
Whether mutations in cancer driver genes directly affect immune phenotype and T cell immunity remains a standing question. ARID1A is core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. occur human cancers drive development. Here, we studied molecular, cellular, clinical impact aberrations on immunity. We demonstrated that resulted limited accessibility to IFN-responsive genes, impaired IFN gene expression, anemic tumor infiltration, poor immunity, shortened...
Tumor-associated macrophages (TAMs) are a major cellular component in the tumor microenvironment (TME). However, relationship between phenotype and metabolic pattern of TAMs remains poorly understood. We performed single-cell transcriptome profiling on hepatic from mice bearing liver metastatic tumors. find that manifest high heterogeneity at levels transcription, development, metabolism, function. Integrative analyses validation experiments indicate increased purine metabolism is feature...
The authorship of the report "The Modulation Fluorouracil With Leucovorin in Metastatic Colorectal Carcinoma: A Randomized Phase III Trial," published October 1989 issue (J Clin Oncol 7:1419–1426, 1989) should have read: "by Gastrointestinal Tumor Study Group." following appendix also appeared at end report:
Background. BK virus (BKV)-associated nephropathy (BKVAN) has been increasingly recognized as an important cause of renal transplant dysfunction. We report the role quantitative viral load monitoring in management BKVAN. Methods. developed a real-time polymerase chain reaction (PCR) assay for BKV detection urine and plasma. Four allograft recipients, including two children, with BKVAN were treated low-dose cidofovir followed prospectively. Results. The PCR showed limit 10 copies intra-assay...
Background Since 1998 the serious public health problem in South East Asia of counterfeit artesunate, containing no or subtherapeutic amounts active antimalarial ingredient, has led to deaths from untreated malaria, reduced confidence this vital drug, large economic losses for legitimate manufacturers, and concerns that artemisinin resistance might be engendered. Methods Findings With evidence a deteriorating situation, group police, criminal analysts, chemists, palynologists, workers...