A5101439568- Selenium in Biological Systems
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Wastewater Treatment and Nitrogen Removal
- Aquaculture disease management and microbiota
- Plant Molecular Biology Research
- Crustacean biology and ecology
- MicroRNA in disease regulation
- Hydrology and Drought Analysis
- Cancer Immunotherapy and Biomarkers
- Photosynthetic Processes and Mechanisms
- Microbial Fuel Cells and Bioremediation
- Plant Stress Responses and Tolerance
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Trace Elements in Health
- Membrane Separation Technologies
- Listeria monocytogenes in Food Safety
- Anaerobic Digestion and Biogas Production
- Phytase and its Applications
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Nuclear Structure and Function
- Plant responses to water stress
- Reproductive Biology and Fertility
Shanxi Academy of Medical Sciences
2025
Shanxi Medical University
2025
University of Michigan
2020-2024
California Institute for Biomedical Research
2023
University of Alabama at Birmingham
2021
Shenzhen University
2020
Chinese Academy of Sciences
2016-2018
Shanghai Institutes for Biological Sciences
2016-2018
Center for Excellence in Molecular Cell Science
2016-2017
Lanzhou University
2017
Whether mutations in cancer driver genes directly affect immune phenotype and T cell immunity remains a standing question. ARID1A is core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. occur human cancers drive development. Here, we studied molecular, cellular, clinical impact aberrations on immunity. We demonstrated that resulted limited accessibility to IFN-responsive genes, impaired IFN gene expression, anemic tumor infiltration, poor immunity, shortened...
MicroRNAs (miRNAs) typically bind to unstructured miRNA-binding sites in target RNAs, leading a mutual repression of expression. Here, we report that miR-1254 interacts with structured elements cell cycle and apoptosis regulator 1 (CCAR1) 5' untranslated region (UTR) this interaction enhances the stability both molecules. can also act as repressor when binding its targets. Interestingly, miR-1254-targeting functional RNA motif-sensing unit, an independent unit Artificially designed miRNA...
Tumor-associated macrophages (TAMs) shape tumor immunity and therapeutic efficacy. However, it is poorly understood whether how post-translational modifications (PTMs) intrinsically affect the phenotype function of TAMs. Here, we reveal that peptidylarginine deiminase 4 (PAD4) exhibits highest expression among common PTM enzymes in TAMs negatively correlates with clinical response to immune checkpoint blockade. Genetic pharmacological inhibition PAD4 prevents progression tumor-bearing mouse...
As a result of global warming, vegetation suffers from repeated freeze-thaw cycles caused by more frequent short-term low temperatures induced hail, snow, or night frost. Therefore, freezing stress plants should be investigated particularly in light the current climatic conditions. Alcohol dehydrogenase (ADH) plays central role metabolism alcohols and aldehydes it is key enzyme anaerobic fermentation. ADH1 responds to plant growth environmental stress; however, function response remains...
Significance During meiosis prophase I in mammals, a series of events occur, such as homologous recombination, DSB repair, crossover formation, XY body and meiotic sex chromosome inactivation (MSCI). We report here that male pachynema-specific (MAPS) protein is essential for progression mouse spermatocytes. Maps knockout causes the demise pachytene spermatocytes throughout early to mid- late pachynema, resulting but not female infertility. Moreover, ubiquitination was dramatically increased...
Abstract Background Selenium is an essential trace element, and selenocysteine (Sec, U) its predominant form in vivo. Proteins that contain Sec are selenoproteins, whose special structural features include not only the TGA codon encoding but also SECIS element mRNA conservation of Sec-flanking region. These unique have led to development a series bioinformatics methods predict research selenoprotein genes. There been some studies reports on evolution distribution genes prokaryotes...
The expression of cold-induced genes is critical for plants to survive under freezing stress. However, the underlying mechanisms decision when, where, and which express are unclear when a plant meets sudden temperature drop. Previous studies have demonstrated epigenetics play central role in regulation gene responses environmental DNA methylation histone deacetylation two most important epigenetic modifications. This study was conducted investigate effects inhibiting on expression, explore...
The modern armamentarium for cancer treatment includes immunotherapy and targeted therapy, such as protein kinase inhibitors. However, the mechanisms that allow cancer-targeting drugs to effectively mobilize dendritic cells (DCs) affect are poorly understood. Here, we report among shared gene targets of clinically relevant inhibitors, high
In the present study, total mitochondrial genome of a precocious Chinese mitten crab Eriocheir sinensis was firstly determined. The is 16,350 bp in length. It consists 13 protein-coding genes, 22 tRNA 2 rRNA genes and control region. overall nucleotide composition A: 35.31 %, G: 10.69 T: 36.37 % C: 17.63%, respectively. These results provide useful information to species identification, conservation analysis mechanisms precocity E. sinensis.
Transcriptome analysis of SPS2 knockdown suggests a new relationship between selenium utilization and fundamental cellular processes as well diseases.
In the present study, complete mitochondrial genome of Sarcocheilichthys nigripinnis (Cypriniformes: Cyprinidae) was sequenced and identified, phylogenetic analysis with other individual fishes carried out. Totally, this is 16,679 bp in length, which consists 13 PCDs, 22 tRNA genes, 2 rRNA non-coding regions. The total base composition is: 30.05% A, 26.40% T, 26.70% C, 16.85% G, respectively. These results will provide useful data for species identification genetics study fishes.
The Chinese mitten crab Eriocheir sinensi belongs to the family Decapoda, Varunidae, Eriocheir. In this study, full length of mitochondrial genome an ovulated was first sequenced and analyzed. It determined be 16,353 bp in length, consists 13 protein coding genes (PCDs), 22 tRNA genes, 2 rRNA 1 control region.
In the present study, complete mitogenome sequence of a Sarcocheilichthys parvus Nichols was sequenced and identified. It contained 22 tRNA genes, 13 protein-coding 2 rRNA genes non-coding regions. The phylogenetic analysis showed that could be useful data in field systematics conservation biology for S. other aquatic species.
The total mitochondrial genome of Hemibarbus labeo (Cypriniformes: Cyprinidae) is 16,612 bases in length. It consists 13 protein-coding genes, 22 tRNA 2 rRNA genes and non-coding regions. overall nucleotide composition the H-strand H. A: 29.82%, G: 17.11%, T: 25.90% C: 27.17%, respectively, with an A + T-rich feature (55.72%). These results will contribute to natural resources conservation species identification H.labeo.
Abstract Background: Selenium is an essential trace element, and selenocysteine (Sec, U) its predominant form in vivo. Proteins that contain Sec are selenoproteins, whose special structural features include not only the TGA codon encoding but also SECIS element mRNA conservation of Sec-flanking region. These unique have led to development a series bioinformatics methods predict research selenoprotein genes. There been some studies reports on evolution distribution genes prokaryotes...
ood wastes, such as animal feedstuff, may result in risks of disease spreading. Changes Staphylococcus aureus and Salmonella the food wastes during storage period were investigated this paper. tested by plate count coagulase test, PCR assay. Results showed that both existed wastes. After 48 h at 20 oC 37 oC, amount decreased from 103 - 105 CFU/g to 102 0 respectively. The 5.5x106 4.6x107 a range between 2.0x104 2.0x105 after it was less than oC. two pathogenic bacteria would be restricted pH...