A5051927389- Immunotherapy and Immune Responses
- Immune cells in cancer
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Immune Response and Inflammation
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Chemokine receptors and signaling
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Adenosine and Purinergic Signaling
- Diet and metabolism studies
- Cell Adhesion Molecules Research
Chinese Academy of Sciences
2012-2025
Shenzhen Institutes of Advanced Technology
2022-2025
University of Michigan
2016-2024
Shenzhen Technology University
2024
Shenzhen University
2024
Michigan Medicine
2023
Kunming Institute of Zoology
2009-2021
ORCID
2021
Michigan United
2016
Abstract The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes cell proliferation, survival, migration tumour growth. Here we show that, cells, stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen of DUBs, identify BAP1 as bona fide DUB. interacts directly with stabilizes via deubiquitination. BAP1/HCF-1 complex, this newly identified complex cycle progression partially inhibiting p27 gene expression. Furthermore, knockdown...
Nonalcoholic steatohepatitis (NASH) is characterized by progressive liver injury, inflammation, and fibrosis; however, the mechanisms that govern transition from hepatic steatosis, which relatively benign, to NASH remain poorly defined. Neuregulin 4 (Nrg4) an adipose tissue–enriched endocrine factor elicits beneficial metabolic effects in obesity. Here, we show Nrg4 a key component of checkpoint preserves hepatocyte health counters diet-induced mice. deficiency accelerated fibrosis, cell...
Naïve T cells are poorly studied in cancer patients. We report that naïve prone to undergo apoptosis due a selective loss of FAK family-interacting protein 200 kDa (FIP200) ovarian patients and tumor-bearing mice. This results poor antitumor immunity via autophagy deficiency, mitochondria overactivation, high reactive oxygen species production cells. Mechanistically, FIP200 disables the balance between proapoptotic antiapoptotic Bcl-2 family members enhanced argonaute 2 (Ago2) degradation,...
Tumor-associated macrophages (TAMs) affect cancer progression and therapy. Ovarian carcinoma often metastasizes to the peritoneal cavity. Here, we found 2 macrophage subsets in mice bearing ID8 ovarian based on T cell immunoglobulin mucin domain containing 4 (Tim-4) expression. Tim-4+ TAMs were embryonically originated locally sustained while Tim-4- replenished from circulating monocytes. TAMs, but not promoted tumor growth vivo. Relative manifested high oxidative phosphorylation adapted...
Triple negative breast cancer (TNBC) is a highly aggressive form of resistant to many common treatments. In this study, we compared the effects 12 phytochemical drugs on four cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC growth by inducing cycle G2/M phase arrest apoptosis. CuE reduced expression Cyclin D1, Survivin, XIAP, Bcl2, Mcl-1 in MDA-MB-468 SW527, within MDA-MB-468, increased activation JNK AKT ERK. Collectively, these results suggest may be viable...
Lysine-63–linked (K63-linked) polyubiquitination of TRAF3 coordinates the engagement pattern-recognition receptors with recruited adaptor proteins and downstream activator TBK1 in pathways that induce type I IFN. Whether autoubiquitination or other E3 ligases mediate K63-linked remains unclear. We demonstrated mice deficient ligase gene Hectd3 remarkably increased host defense against infection by intracellular bacteria Francisella novicida, Mycobacterium, Listeria limiting bacterial...
Abstract Metastasis is the leading cause of cancer-related death. The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs a key step during extravasation hematogenous metastasis. Surgery common intervention for most primary solid tumors. However, surgical trauma-related systemic inflammation facilitates metastasis by increasing spread to vascular (ECs). Currently, there are no effective interventions prevent Here, we show that HECTD3 deficiency...
Tumor-associated macrophages (TAMs) shape tumor immunity and therapeutic efficacy. However, it is poorly understood whether how post-translational modifications (PTMs) intrinsically affect the phenotype function of TAMs. Here, we reveal that peptidylarginine deiminase 4 (PAD4) exhibits highest expression among common PTM enzymes in TAMs negatively correlates with clinical response to immune checkpoint blockade. Genetic pharmacological inhibition PAD4 prevents progression tumor-bearing mouse...
The tree shrew is becoming an attractive experimental animal model for human breast cancer owing to a closer relationship primates/humans than rodents. Tree shrews are superior classical primates because easier manipulate, maintain and propagate. It required establish high-efficiency etiological research drug assessment. Our previous studies suggest that 7,12-dimethylbenz(a)anthracene (DMBA) medroxyprogesterone acetate (MPA) induce tumors in with low frequency (<50%) long latency (∼...
Abstract Cancer treatment continues to shift from utilizing traditional therapies targeted ones, such as protein kinase inhibitors and immunotherapy. Mobilizing dendritic cells (DC) other myeloid with antigen presenting cancer cell killing capacities is an attractive but not fully exploited approach. Here, we show that PIKFYVE a shared gene target of clinically relevant high expression this in DCs associated poor patient response immune checkpoint blockade (ICB) therapy. Genetic...
Krüppel-like factors (KLFs) are a family of zinc finger transcription regulating embryonic development and diseases. The phylogenetics KLFs has not been studied in tree shrews, an animal lineage with closer relationship to primates than rodents. Here, we identified 17 from Chinese shrew (Tupaia belangeri chinensis). KLF proteins highly conserved among humans, monkeys, rats, mice shrews compared zebrafish chickens. CtBP binding site, Sin3A site nuclear localization signals largely between...
Abstract Background Haloxylon ammodendron holds significance as an ecological plant, showcasing remarkable adaptability to desert conditions, halophytic environments, and sand fixation. With its potential for carbon sequestration, it emerges a promising candidate environmental sustainability. Furthermore, serves valuable C4 plant model, offering insights into the genetic foundations of extreme drought tolerance. Despite availability plastid nuclear genomes, absence mitochondrial genome...
Abstract Background Several studies have demonstrated that SIV infection progresses more slowly to experimental AIDS in Chinese rhesus macaques (Ch Rhs) than Indian (Ind Rhs). Here we investigated the dynamic and functional changes dendritic cell (DC) subsets SIVmac239-infected Ch Rhs. Results The numbers of both mDC pDC strongly fluctuated but were not significantly changed during acute chronic phases infection. However, concentration poly (I:C)-induced IL-12 HSV-1-induced IFN-α increased...