A5023919249- Cardiac Imaging and Diagnostics
- Corneal Surgery and Treatments
- Identification and Quantification in Food
- Plant Gene Expression Analysis
- Coronary Interventions and Diagnostics
- Cancer, Lipids, and Metabolism
- Aquatic Invertebrate Ecology and Behavior
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- RNA modifications and cancer
- Mesenchymal stem cell research
- Myasthenia Gravis and Thymoma
- Cardiac Fibrosis and Remodeling
- Photosynthetic Processes and Mechanisms
- Inflammasome and immune disorders
- Coronary Artery Anomalies
- Autophagy in Disease and Therapy
- Tea Polyphenols and Effects
- Nuclear Structure and Function
Peking University
2023-2025
Peking University Cancer Hospital
2023-2025
Inner Mongolia Medical University
2023-2025
ShenZhen People’s Hospital
2025
Sir Run Run Shaw Hospital
2024
Chinese Academy of Sciences
2020-2024
Shanghai Institutes for Biological Sciences
2024
Center for Excellence in Molecular Plant Sciences
2021-2024
Zhejiang University
2024
University of Chinese Academy of Sciences
2023
Abstract Gut microbial transformations of flavonoids, an enormous class polyphenolic compounds abundant in plant-based diets, are closely associated with human health. However, the enzymes that initiate gut metabolism flavones and flavonols, two most groups as well their underlying molecular mechanisms action remain unclear. Here, we discovered a flavone reductase (FLR) from bacterium, Flavonifractor plautii ATCC 49531 (originally assigned Clostridium orbiscindens DSM 6740), which...
A novel method to separate and purify tea seed polysaccharide saponin from camellia cake extract by macroporous resin was developed. Among four kinds of resins (AB‐8, NKA‐9, XDA‐6, D4020) tested, AB‐8 possessed optimal separating capacity for the two substances thus selected separation, in which deionized water used elute polysaccharide, 0.25% NaOH solution remove undesired pigments, 90% ethanol saponin. Further dynamic adsorption/desorption experiments on resin‐based column chromatography...
MicroRNAs (miRNAs) play vital roles in the regulation of fruit development and ripening. Blueberry is an important small berry crop with economical nutritional value. However, nothing known about miRNAs their targets involved blueberry In this study, using high-throughput sequencing RNAs, 84 belonging to 28 families 16 novel were identified white (WF) blue (BF) libraries, which represent ripening onset progress, respectively. Among them, 41 shown be differentially expressed during...
A water-compatible molecularly imprinted polymer was prepared by Pickering emulsion polymerization using halloysite nanotubes as stabilized solid particles. During polymerization, we used 4-vinylpyridine monomer, divinylbenzene cross-linking agent, toluene porogen, 2,2-azobisisobutyronitrile initiator, 2,4-dichlorophenoxyacetic acid template to form the oil phase, and Triton X-100 aqueous solution water phase. The characterized Fourier transform infrared spectroscopy scanning electron...
As a featured ocular inflammatory disease, autoimmune uveitis is the major cause of blindness in clinic. Although current immunosuppressive regimens can alleviate progression uveitis, they have serious side effects. Therefore, an alternative therapeutic strategy urgently required. The present study investigated efficacy human amniotic epithelial cells (hAECs) on rat model. Herein, experimental (EAU) was induced rats via subcutaneous injection interphotoreceptor retinoid-binding protein. EAU...
Non-small cell lung cancer (NSCLC) progression is aggressive carrying a high risk of death. In the disease, little known about mechanism circRNA (circ)-C20orf11, and further in-depth studies are needed. First, circ-C20orf11 expression in NSCLC was assessed, effects on proliferative, apoptotic, migratory, invasive behaviors were detected after transfection. The targeting relationship between miRNA (miR)-495-3p or recombinant karyopherin alpha 2 (KPNA2) validated. We found elevated NSCLC,...
In recent years, the acyl-Coenzyme A thioester hydrolase family (ACOTs) has received wide attention as a key link in lipid metabolism. This is class of enzymes that catalyze hydrolysis fatty A, disrupting bond present within acyl-CoA ester molecules to produce free acids (FFA) and corresponding coenzyme (CoA). Such play very important role metabolism through maintaining appropriate levels intracellular FFA well CoA. It broadly divided into two distinct subgroups, type-I α/β-hydrolase fold...
Abstract Background Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently. BBR can intervene control malignant colorectal cancer (CRC) through intestinal microbes, but the direct molecular target related mechanism are unclear. This study aimed to identify of dissect mechanisms against occurrence development CRC from perspective microorganisms. Results Here, we that inhibits growth several CRC-driving bacteria, especially...
Abstract Thymoma is the most common tumor of anterior mediastinum. Routine imaging methods such as computed tomography or magnetic resonance often lead to misdiagnosis between thymoma and other thymic abnormalities. Therefore, urgently needed develop a new diagnostic strategy. Here we identify interleukin-8 (IL-8) biomarker for auxiliary diagnosis thymoma. We find that IL-8 levels in naïve T cells are markedly elevated patients with compared those tumors. naive significantly decreased after...
SQUAMOSA Promoter Binding Protein (SBP) family genes act as central players to regulate plant growth and development with functional redundancy specificity. Addressing the diversity of SBP in crops is great significance precisely utilize them improve agronomic traits. Blueberry an important economic berry crop. However, has not been described blueberry. In present study, twenty VcSBP were identified through data mining against blueberry transcriptome databases. These VcSBPs could be...
The recently identified adipocytokine omentin was previously found to be expressed mainly in human omental and visceral adipose tissues. As such, reduced plasma concentrations of were revealed associated with increased risks cardiovascular diseases. Omentin has also been demonstrated exert anti-inflammatory effects. By contrast, resistin is a protein that obesity type-2 diabetes mellitus, the serum concentration significantly these populations. Resistin involved mediating inflammation...
Gut microbes are closely related with human health, but remain much to learn.
Long noncoding RNAs (lncRNAs) exert essential effects in regulating myocardial ischemia/reperfusion (MI/R)-induced injury. This work intended to explore the functions of lncRNA SOX2-OT and its regulatory mechanism within MI/R-induced In this study, gene expression was determined by RT-qPCR. Western blotting applied for detection protein levels. Pro-inflammatory cytokine concentrations, cardiomyocyte viability, apoptosis were detected via ELISA, CCK-8 flow cytometry. vitro model, YY1 both...
Dysregulation of lipid metabolism is common in cancer. However, the molecular mechanism underlying esophageal squamous cell carcinoma (ESCC) and its effect on patient prognosis are not well understood. The objective our study was to construct a metabolism-related prognostic model improve prediction ESCC.We downloaded mRNA expression profiles corresponding survival data patients with ESCC from Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) databases. We performed differential...
Histone acetylation is one of the most common epigenetic modifications and plays a crucial role in tumorigenesis. However, prognostic significance histone acetylation-related lncRNAs (HARlncRNAs) esophageal carcinoma (ESCA) not well understood. A total 653 differentially expressed (DElncRNAs) were identified between 162 ESCA tissues 11 normal TCGA database, 7 them correlated with regulators. We employed univariate Cox regression analysis, combining it clinical prognosis information, to...
Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are the main treatment methods for left disease (LMAD) triple-vessel (TVCAD).This study aimed to evaluate five-year post-treatment effects of CABG PCI in patients with severe vasculopathy.A total 430 LMAD and/or from November 2014 July 2015 were enrolled retrospectively affiliated cardiovascular hospital Shanxi Medical University divided into group group. The living conditions obtained through medical records...