A5082874678- Antimicrobial Peptides and Activities
- Plant biochemistry and biosynthesis
- Biochemical and Structural Characterization
- Aquaculture disease management and microbiota
- Neurobiology and Insect Physiology Research
- Microbial Natural Products and Biosynthesis
- Invertebrate Immune Response Mechanisms
- Plant Gene Expression Analysis
- Venomous Animal Envenomation and Studies
- Natural product bioactivities and synthesis
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Supramolecular Chemistry and Complexes
- Photosynthetic Processes and Mechanisms
- Cellular transport and secretion
- Molecular Sensors and Ion Detection
- Marine and coastal ecosystems
- Plant Molecular Biology Research
- Essential Oils and Antimicrobial Activity
- Insect Resistance and Genetics
- Luminescence and Fluorescent Materials
- Aquatic Ecosystems and Phytoplankton Dynamics
- Insect and Pesticide Research
- Neuropeptides and Animal Physiology
Shanghai Chenshan Plant Science Research Center
2024-2025
Center for Excellence in Molecular Plant Sciences
2015-2025
Chinese Academy of Sciences
2014-2024
Shanghai Institutes for Biological Sciences
2007-2024
Dalian University of Technology
2023-2024
Dalian University
2023-2024
University of Chinese Academy of Sciences
2011-2023
Emory University
2009-2021
Southern Medical University
2021
Shenzhen Maternity and Child Healthcare Hospital
2020-2021
Peptidomics and genomics analyses were used to study an anti-infection array of peptides amphibian skin. 372 cDNA sequences antimicrobial characterized from a single individual skin the frog Odorrana grahami that encode 107 novel peptides. This contribution almost triples number currently reported The could be organized into 30 divergent groups, including 24 groups. diversity in peptide coding is, our knowledge, most extreme yet described for any animal. patterns diversification suggest...
The phytohormone cytokinin has various roles in plant development, including meristem maintenance, vascular differentiation, leaf senescence, and regeneration. Prior investigations have revealed that acts via a phosphorelay similar to the two-component system by which bacteria sense respond external stimuli. eventual targets of this are type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs), containing conserved N-terminal receiver domain (RD), middle DNA binding (DBD), C-terminal transactivation...
Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms Bungarus fasciatus and it is first identified cathelicidin peptide reptiles. In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium acnes. Its minimal inhibitory concentration two strains P. acnes 4.7 µg/ml. also effectively killed other microorganisms including...
Most TPSs (terpene synthases) contain plasticity residues that are responsible for diversified terpene products and functional evolution, which provide a potential improving catalytic efficiency. Artemisinin, sesquiterpene lactone from Artemisia annua L., is widely used malaria treatment progress has been made in engineering the production of artemisinin or its precursors. In present paper, we report new synthase A. annua, AaBOS (A. α-bisabolol synthase), high sequence identity with AaADS...
Idiopathic central precocious puberty (ICPP) is a common disease in preadolescence girls, and its pathogenesis remains to be uncovered. A variety of studies highlighted the association gut microbiota (GM) with endocrine diseases, such as obesity, which complication ICPP. However, relationship between GM ICPP unexplored. Feces samples were collected from 25 girls (ICPP group) 23 healthy (Control group). We applied 16S rDNA sequencing compare two groups. The group had higher diversity was...
BackgroundLectins are sugar-binding proteins that specifically recognize sugar complexes. Based on the specificity of protein–sugar interactions, different lectins could be used as carrier molecules to target drugs cells which express glycan arrays. In spite lectin's interesting biological potential for drug targeting and delivery, a disadvantage natural may large size results in immunogenicity toxicity. Smaller peptides can mimic function promising candidates targeting.Principal...
Jawless vertebrates (cyclostomes) have an alternative adaptive immune system in which lymphocytes somatically diversify their variable lymphocyte receptors (VLR) through recombinatorial use of leucine-rich repeat cassettes during VLR gene assembly. Three types these anticipatory lampreys (VLRA, VLRB, and VLRC) are expressed by separate lineages. However, only two genes (VLRA VLRB) been found hagfish. Here we identified a third hagfish VLR, undergoes somatic assembly to generate sufficient...
Diterpene glycosyltransferase UGT76G1 from Stevia rebaudiana (SrUGT76G1) is key to the generation of economically important steviol glycosides (SGs), a group natural sweeteners with high-intensity sweetness. SrUGT76G1 accommodates wide range steviol-derived substrates and many other small molecules. We report here crystal structures in complex multiple ligands answer how this enzyme recognizes diterpenoid aglycones catalyzes 1,3-sugar chain branching. A spacious pocket for sugar-acceptor...
Tanshinone ⅡA (TⅡA), a diterpene quinone with furan ring, is bioactive compound found in the medicinal herb redroot sage (Salvia miltiorrhiza Bunge), which both and dihydrofuran analogs are present abundance. Progress has been made recently elucidating tanshinone biosynthetic pathway, including heterocyclization of D-ring by cytochrome P450s; however, dehydrogenation to furan, key step ring formation, remains uncharacterized. Here, differential transcriptome mining, we identified six...
Abstract Supramolecular artificial light‐harvesting system with highly efficient host–guest energy transfer pathway provides an ideal platform for optimizing the photochemistry process. The consecutive photo‐induced electron (conPET) process overcomes limitation of visible‐light photocatalysis, but is often compromised by mismatching between absorption ground state dye and its radical, weakening efficiency photoredox reaction. By encapsulating a conPET photocatalyst rhodamine 6G into...
The disulfide-bridged hendecapeptide (CWTKSIPPKPC) loop, derived from an amphibian skin peptide, is found to have strong trypsin inhibitory capability. This called the loop (TIL), appears be smallest serine protease inhibitor known. A series of synthetic peptides this also exhibits activity;some even exhibit both antimicrobial and activities. Antimicrobial are attractive candidates for producing novel antibiotics, but their sensitivity trypsin-like proteases appreciably limits application....
Class I terpene synthase (TPS) generates bioactive terpenoids with diverse backbones. Sesterterpene (sester-TPS, C25), a branch of class TPSs, was recently identified in Brassicaceae. However, the catalytic mechanisms sester-TPSs are not fully understood. Here, we first three nonclustered functional (AtTPS06, AtTPS22, and AtTPS29) Arabidopsis thaliana. AtTPS06 utilizes type-B cyclization mechanism, whereas most other produce various sesterterpene backbones via type-A mechanism. We then...