A5100692710- Antimicrobial Peptides and Activities
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Biochemical and Structural Characterization
- Network Security and Intrusion Detection
- Internet Traffic Analysis and Secure E-voting
- Advanced Malware Detection Techniques
- Immune Response and Inflammation
- Cancer Genomics and Diagnostics
- Protein Hydrolysis and Bioactive Peptides
- Spam and Phishing Detection
- Prostate Cancer Treatment and Research
- Bacterial Genetics and Biotechnology
- Cancer Cells and Metastasis
- Smart Agriculture and AI
- Insect Utilization and Effects
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- RNA regulation and disease
- HER2/EGFR in Cancer Research
- Peptidase Inhibition and Analysis
- Microbial Metabolic Engineering and Bioproduction
- Marine Sponges and Natural Products
- Microbial Metabolites in Food Biotechnology
- Probiotics and Fermented Foods
Hebei University
2019-2025
Sorbonne Université
2025
Laboratoire Jacques-Louis Lions
2023-2025
Yantai Institute of Coastal Zone Research
2010-2024
Chinese Academy of Sciences
2011-2024
Soochow University
2015-2024
University of California, Riverside
2023-2024
University of Chinese Academy of Sciences
2009-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Capital Medical University
2014-2024
Bacterial populations produce persister cells that neither grow nor die in the presence of microbicidal antibiotics. Persisters are largely responsible for high levels biofilm tolerance to antimicrobials, but virtually nothing was known about their biology. Tolerance Escherichia coli ampicillin and ofloxacin tested at different growth stages gain insight into nature persisters. The number persisters did not change lag or early exponential phase, increased dramatically mid-exponential phase....
Horizontal gene transfer plays a major role in microbial evolution. However, newly acquired sequences can decrease fitness unless integrated into preexisting regulatory networks. We found that the histone-like nucleoid structuring protein (H-NS) selectively silences horizontally genes by targeting with GC content lower than resident genome. Mutations hns are lethal Salmonella accompanied compensatory mutations other loci. Thus, H-NS provides previously unrecognized mechanism of bacterial...
Tau pathology in AD spreads a hierarchical pattern, whereby it first appears the entorhinal cortex, then to hippocampus and later surrounding areas. Based on this sequential appearance, can be classified into six stages ("Braak stages"). The mechanisms agents underlying progression of are matter debate. Emerging evidence indicates that propagation may due transmission protein, but pathways species not well understood. In study we investigated question spreading via small extracellular...
We have cloned human cDNA encoding double-stranded RNA adenosine deaminase (DRADA). DRADA is a ubiquitous nuclear enzyme that converts multiple adenosines to inosines in double-helical substrates without apparent sequence specificity. The A --> I conversion activity of the protein encoded by was confirmed recombinant expression insect cells. Use DNA as molecular probe documented conservation across mammals and detected single transcript 7 kb all tissues analyzed. deduced primary structure...
Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) novel discovery strategy selective protein degradation from within cells.
The abnormal aggregation of tau protein into paired helical filaments (PHFs) is one the hallmarks Alzheimer's disease. Aggregation takes place in cytoplasm and could therefore be cytotoxic for neurons. To find inhibitors PHF we screened a library 200,000 compounds. hits found inhibition assay were also tested their ability to dissolve preformed PHFs. results obtained using thioflavin S fluorescence detection quantification solution, tryptophan tryptophan-containing mutants tau, confirmed by...
Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules innate immunity, which firstly found in mammalians. Recently, several cathelicidins have also been from chickens and fishes. No other non-mammalian vertebrates reported.In this work, cathelicidin-like peptide named cathelicidin-BF has purified the snake venoms Bungarus fasciatus its cDNA sequence was cloned library, confirm presence cathelicidin reptiles. As cathelicidins, precursor...
Extracting the protocol message format specifications of unknown applications from network traces is important for a variety such as application parsing, vulnerability discovery, and system integration. In this paper, we propose ProDecoder, trace based inference that exploits semantics messages without executable code protocols. ProDecoder on key insight n-grams exhibit highly skewed frequency distribution can be leveraged accurate inference. first discover latent relationship among by...
Autoimmune hepatitis (AIH) in humans is a severe inflammatory liver disease characterized by interface hepatitis, the presence of circulating autoantibodies, and hyper-gammaglobulinemia. There are two types AIH, type 1 (AIH-1) 2 (AIH-2), distinct autoimmune serology. Patients with AIH-1 positive for anti-smooth muscle and/or antinuclear whereas patients AIH-2 have anti-liver kidney microsomal cytosol autoantibodies. Cytochrome P4502D6 antigenic target 1, formiminotransferase cyclodeaminase...
While programmed death 1 (PD-1) and death-ligand (PD-L1) checkpoint inhibitors have activity in a proportion of patients with advanced bladder cancer, strongly predictive prognostic biomarkers are still lacking. In this study, we evaluated PD-L1 protein expression on circulating tumor cells (CTCs) isolated from muscle invasive (MIBC) metastatic (mBCa) cancer explore the value CTC clinical outcomes. Blood samples 25 MIBC or mBCa were collected at UCSF shipped to Epic Sciences. All nucleated...
Rapid antimicrobial action is an important advantage of peptides (AMPs) over antibiotics, which also a reason for AMPs being less likely to induce bacterial resistance. However, the structural parameters and underlying mechanisms affecting killing rate remain unknown. In this study, we performed structure–activity relationship (SAR) study using As-CATH4 5 as templates. We revealed that hydrophobicity, rather than other characteristics, critical parameter determining α-helical AMPs. With...
Non-direct antimicrobial cationic peptides (NDACPs) are components of the animal innate immune system. But their functions and association with (AMPs) incompletely understood. Here, we reveal a synergistic interaction between AMP AW1 NDACP AW2, which co-expressed in frog Amolops wuyiensis. AW2 enhances antibacterial activity both vitro vivo, while mitigating development bacterial resistance eradicating biofilms. synergistically damage membranes, facilitating cellular uptake intracellular...
In Escherichia coli, FtsN localizes late to the cell division machinery, only after a number of additional essential proteins are recruited early FtsZ-FtsA-ZipA complex. has short, positively charged cytoplasmic domain (FtsN(Cyto)), single transmembrane (FtsN(TM)), and periplasmic that is for function. Here we show FtsA interact directly in vitro. FtsN(Cyto) sufficient bind FtsA, but when it tethered FtsN(TM) or leucine zipper. Mutation conserved patch positive charges negative abolishes...
Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms Bungarus fasciatus and it is first identified cathelicidin peptide reptiles. In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium acnes. Its minimal inhibitory concentration two strains P. acnes 4.7 µg/ml. also effectively killed other microorganisms including...
Traffic classification, a mapping of traffic to network applications, is important for variety networking and security issues, such as measurement, monitoring, well the detection malware activities. In this paper, we propose Securitas, trace-based protocol identification system, which exploits semantic information in message formats. Securitas requires no prior knowledge specifications. Deeming language between two processes, our approach based upon new insight that n-grams traces, just like...