A5104298739- Skin and Cellular Biology Research
- Circular RNAs in diseases
- Autoimmune Bullous Skin Diseases
- Sustainable Building Design and Assessment
- Food composition and properties
- MicroRNA in disease regulation
- Essential Oils and Antimicrobial Activity
- Polysaccharides Composition and Applications
- Polysaccharides and Plant Cell Walls
- Experimental Learning in Engineering
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Nuclear materials and radiation effects
- Seaweed-derived Bioactive Compounds
- Recycling and utilization of industrial and municipal waste in materials production
- Phytochemistry and Biological Activities
- Medicinal Plants and Neuroprotection
- Bioactive Natural Diterpenoids Research
- Glass properties and applications
- Landscape and Cultural Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Tannin, Tannase and Anticancer Activities
- Photochemistry and Electron Transfer Studies
- Regional Development and Environment
Dalian Polytechnic University
2014-2025
Dalian University of Technology
2025
Children's Hospital of Zhejiang University
2019-2025
Guangdong University of Technology
2024
Shanghai Institute of Technology
2013-2024
China Guangzhou Analysis and Testing Center
2024
Capital Medical University
2023
Henan Provincial People's Hospital
2021-2023
Zhengzhou University
2021-2023
Beijing Friendship Hospital
2023
Abstract Acquired resistance to chemotherapy is a major obstacle in breast cancer (BC) treatment. Accumulated evidence has uncovered that microRNAs (miRNAs) are vital regulators of chemoresistance cancer. Growing studies reveal miR-137 acts as suppressor tumor progression. However, it remains obscure the role modulating sensitivity BC cells doxorubicin (DOX). In this study, we demonstrate exerts significant effect on repressing development response DOX via attenuating epithelial-mesenchymal...
Cisplatin (DDP) is one of the first-line chemotherapeutic agents for non-small cell lung cancer (NSCLC). However, repeated use cisplatin in clinical practice often induces chemoresistance. The aims this study were to investigate whether rosmarinic acid (RA) could reverse multidrug resistance (MDR) NSCLC and explore underlying mechanisms. Our data demonstrated that RA significantly inhibited proliferation colony formation a dose-dependent manner, induced G1 phase cycle arrest apoptosis,...
Cisplatin represents one of the first‐line drugs used for non‐small‐cell lung cancer treatment. However, considerable side effects and emergence drug resistance are becoming critical limitations to its application. Combinatorial strategies may be able extend use cisplatin. Both Tanshinone IIA cisplatin inhibit cell growth in a time‐ dose‐dependent manner. When was combined with at ratio 20:1, they were observed exert synergistic inhibitory effect on cells. The combination treatment shown...
Essential oil of cinnamon (CM) is a potential alternative to chemical fungicides. Thus this work aimed investigate the possible effects CM microemulsions on decay developments and qualitative properties pears.The incidence samples treated with 500 µg L⁻¹ microemulsion was significantly reduced by 18.7% in comparison that non-microemulsion after 4 days' storage at 20 °C. In vapor phase, lowest concentration had best control for lesion diameter. The interval between inoculations also...
Education is the foundation of a country, strong country. Under rural revitalization strategy, transformation primary school teaching buildings has become one important issues. At present, world environment been destroyed, and environmental protection problem imminent, but in some areas China, there are problems such as insufficient use resources, unreasonable layout structure, ecological greening. Therefore, author proposes design strategy for sustainability. When using environment-friendly...
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis childhood IgAN remains unclear, and there lack effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed children with to delineate cellular molecular compositions, subcluster analysis macrophages conducted. Blood samples were collected from 38 measure soluble TREM2 (sTREM2) CD163 (sCD163) levels analyse their clinical significance. identified...
The naturally occurring amino acid ergothioneine (EGT) has excellent free radical scavenging ability, which was not different to ascorbic acid. IC50 values for EGT hydrogen peroxide, hydroxyl radicals, and superoxide anions were 11.65 ± 0.31, 70.31 1.59, 160.44 0.32 μg/mL, respectively. concentration in species of mushrooms significantly (p < 0.05), but it related the ability scavenge reactive oxygen > 0.05). After isolating from mushrooms, we demonstrated that antioxidant accounts about 25%...
Abstract Background Numerous microRNAs (miRNAs) have been identified as functional molecules in Alzheimer's disease (AD) pathogenesis. This study aimed to investigate the diagnostic value of microRNA‐485‐3p (miR‐485‐3p) AD patients, evaluate effect miR‐485‐3p on neuronal viability and neuroinflammation, well underlying molecular mechanisms. Methods Quantitative Real‐Time PCR was used estimate expression AKT3. A ROC analysis miR‐485‐3p. The correlation with patients' MMSE score inflammatory...
DNA polymerase κ (POLκ) is a low fidelity translesional implicated in spontaneous and damage-induced mutagenesis. We have previously shown that POLκ was frequently overexpressed human lung cancer tissues as compared with their matched non-tumorous tissue counterpart. In the present study, we found close correlation between elevated expression p53 inactivation tissues. To investigate whether POLK might be regulated by p53, determined transcriptional initiation site of gene examined its...
Porous carbohydrate materials such as tobacco shreds readily absorb moisture and become damp during processing, storage, consumption (smoking). Traditional humectants have the ability of retention but moisture-proofing is poor. Polygonatum cyrtonema Hua polysaccharide (PCP 85−1−1) was separated by fractional precipitation purified anion exchange gel permeation chromatography. The average molecular weight (Mw) PCP 85−1−1 2.88 × 103 Da. monosaccharide composition implied that consisted fucose,...
Concurrent malignancy and IgA nephropathy are rare. Despite the lack of solid experimental evidence, there theoretical hypotheses pathophysiology for development glomerular damage in cancer patients, like aberrant immune activities. Here, we describe a nine-year-old child who was admitted due to nephrotic syndrome. Abdominal imaging examination accidentally revealed retroperitoneal tumor, surgical resection performed with pathological diagnosis neuroblastoma. However, complete removal tumor...
Abstract Background Spinal cord astrocytoma is a rare neoplasm, and patients usually recur within months after surgery. There currently lack of consensus regarding post-operative treatment. Clinical data on the activity systemic treatment like chemoradiotherapy anti-angiogenic agents also remained scant. Next-generation sequencing (NGS) -based genomic profiling thus may help identify potential options for subset that harbor actionable genetic alterations. Case presentation We reported first...
Two kinds of β-glucan were extracted from barley flour and bran, with the purity 75.3% 76.2% respectively. Molecular size characterization was caarried out high performance exclusion chromatograhy combined a multi-angle laser light scattering refractive index detector (HPSEC-MALL) , molecular weight (M w ) bran 2.262×10 4 ,7.128×10 . X-ray diffraction thermodynamics tests indicated that all β-glucans noncrystalline but thermostable polymers. Differential scanning calorimetry (DSC) showed...