A5102645913- Mesenchymal stem cell research
- Renal Diseases and Glomerulopathies
- Hormonal Regulation and Hypertension
- Cytokine Signaling Pathways and Interactions
- Plant-based Medicinal Research
- Ion Transport and Channel Regulation
- Hematopoietic Stem Cell Transplantation
- Vasculitis and related conditions
- Cytomegalovirus and herpesvirus research
- Cancer, Lipids, and Metabolism
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- Asthma and respiratory diseases
- RNA regulation and disease
- Cancer therapeutics and mechanisms
- ATP Synthase and ATPases Research
- Lysosomal Storage Disorders Research
- Ferroptosis and cancer prognosis
- IL-33, ST2, and ILC Pathways
- SARS-CoV-2 and COVID-19 Research
- Nuclear Structure and Function
- Glycogen Storage Diseases and Myoclonus
- Urinary Tract Infections Management
Children's Hospital of Zhejiang University
2019-2025
China Southern Power Grid (China)
2025
PLA Navy General Hospital
2024
Creative Commons
2021
Southwest Medical University
2020-2021
Weatherford College
2021
Sichuan Mianyang 404 Hospital
2014
Jiangsu University
2006-2010
Zhejiang University
2006-2009
Institute of Cell Biology
2007
This study aimed to investigate the potentials of ex vivo expansion and pluridifferentiation cryopreserved adult human bone marrow mesenchymal stem cells (hMSCs) into adipocytes neurocytes. Cryopreserved hMSCs were resuscitated cultured for 15 passages, then induced neurocytes with corresponding induction medium. The observed morphological properties expression triglyceride or neuron-specific enolase nestin was detected. result showed that in medium consisting dexamethasone,...
Background The prevalence of major depressive disorder (MDD) is higher in those with low levels educational attainment, the unemployed and social status. However extent to which these factors cause MDD unclear. Most available data comes from studies developed countries, findings may not extrapolate developing countries. Examining relationship between socio economic status China likely add debate because radical changes occurring over last 30 years. Principal We report results 3,639 Chinese...
Steroid-sensitive nephrotic syndrome (SSNS) accounts for approximately 80% of cases syndrome. The involvement aberrant lipid metabolism in early SSNS is poorly understood, warranting further investigation. This study aimed to explore alterations associated with pathogenesis.
In existing two-stage single-phase dynamic voltage restorer (DVR) sag mitigation devices, the output-side power contains a pulsating component at twice fundamental frequency (2f0), leading to presence of second-order ripple currents (SRCs) on DC input side. This, some extent, affects reliability system and has significant impact lifespan energy storage devices. this study, dual-loop control method buck/boost converter is combined with virtual impedance auxiliary strategy suppress SRCs....
This study was supported by grants of New Ideas Capability for Backbone Teachers in Universities Heilongjiang and Scientific Research foundation Qiqihar Medical College. Background/ Aims: Ulcer recurrence poor healing may be critically important to the development serious gastrointestinal complications patients with long-term non-steroid anti-inflammatory drugs (NSAIDs). The present is investigate effects aspirin on ulcer quality explore mechanism. Methods: Gastric ulcers were induced acetic...
Abstract Human bone marrow mesenchymal stem cells (hMSCs) are promising candidates for cell therapy and tissue engineering. The life span of hMSCs during in vitro culture is limited. telomerase catalytic subunit (hTERT) gene transduction can prolong the maintain their potential osteogenic differentiation. We established a line transduced with exogenous hTERT (hTERT‐hMSCs) investigated its sustaining cellular properties long‐term culture. This hTERT‐hMSCs was cultured 290 population doublings...
Programmed cell death (PCD) induction is a promising strategy for killing gastric cancer cells. In this study, we investigated the effects of chrysophanol on apoptosis and ferroptosis in Chrysophanol concentrations ranging from 0 to 100 μM were used treat GES-1, HGC-27 AGS Cell counting kit-8 assay, colony formation 5-ethynyl-2'-deoxyuridine staining, flow cytometry, JC-1 probe insertion, dihydroethidium staining western blotting performed. The cells evaluated vivo using xenograft mouse...
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis childhood IgAN remains unclear, and there lack effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed children with to delineate cellular molecular compositions, subcluster analysis macrophages conducted. Blood samples were collected from 38 measure soluble TREM2 (sTREM2) CD163 (sCD163) levels analyse their clinical significance. identified...
Nephrotic syndrome is common in children and adults worldwide, steroid-sensitive nephrotic (SSNS) accounts for 80%. Aberrant metabolism involvement early SSNS sparsely studied, its pathogenesis remains unclear. Therefore, the goal of this study was to investigate changes initiated patients-related metabolites through serum urine metabolomics discover novel potential metabolic pathways.Serum samples (27 56 controls) (17 24 were collected. Meanwhile, non-targeted analyses performed by...
Microgravity (MG) results in a reduction bone formation. Bone formation involves osteogenic differentiation from mesenchymal stem cells (hMSCs) marrow. We modeled MG to determine its effects on osteogenesis of hMSCs and used activators or inhibitors signaling factors regulate differentiation. Under induction, reduced decreased the expression osteoblast gene markers. The Runx2 was also inhibited, whereas PPARgamma2 increased. phosphorylation ERK, but increased p38MAPK. SB203580, p38MAPK...
Abstract Introduction: Systemic lupus erythematosus (SLE) is a multisystem, chronic, autoimmune disease which can affect any organ system including the eye. About one-third of patients be diagnosed with SLE-related eye involvement usually indicative activity. Retinopathy one most vision-threatening complications that associated disease. Patient concerns: An 11-year-old girl was hospitalized complains repeated swelling and pain in her extremities for 1 month, chest 24 days, rash 5 days...
Wilms tumor (WT), also known as nephroblastoma, is a rare primary malignancy in all kinds of tumor. With the development second-generation sequencing, discovery new markers and potential therapeutic targets has become easier. This study aimed to explore WT prognostic biomarkers. In this study, WT-miRNA datasets GSE57370 GSE73209 were selected for expression profiling identify differentially expressed genes. The key gene miRNA, namely hsa-miR-30c-5p, was identified by overlapping, target...
Abstract Background Steroid-resistant nephrotic syndrome (SRNS) is characterized by unrelieved proteinuria after an initial 4–8 weeks of glucocorticoid therapy. Genes in podocytes play important role causing SRNS. Objective This study aimed to report a pathogenic mutation SRNS patients and investigate its effects on podocytes, as well the mechanism. Methods We screened out novel using whole-exon sequencing cohort verified it via Sanger sequencing. Conservative analysis bioinformatic were...
Concurrent malignancy and IgA nephropathy are rare. Despite the lack of solid experimental evidence, there theoretical hypotheses pathophysiology for development glomerular damage in cancer patients, like aberrant immune activities. Here, we describe a nine-year-old child who was admitted due to nephrotic syndrome. Abdominal imaging examination accidentally revealed retroperitoneal tumor, surgical resection performed with pathological diagnosis neuroblastoma. However, complete removal tumor...
CONCLUSION:The TPO/FL-transduced hMSCs, in combination with additive cytokines, can effectively expand hematopoietic progenitors from UCB vitro and the tfhMSCs coculture system may be a suitable for ex vivo manipulation of primitive progenitor cells under contact culture conditions.