A5101593191- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neuroinflammation and Neurodegeneration Mechanisms
- Granular flow and fluidized beds
- Nuclear Receptors and Signaling
- Landslides and related hazards
- S100 Proteins and Annexins
- Neurotransmitter Receptor Influence on Behavior
- Hydraulic Fracturing and Reservoir Analysis
- Immune cells in cancer
- Air Quality and Health Impacts
- Receptor Mechanisms and Signaling
- Geotechnical and Geomechanical Engineering
- Memory and Neural Mechanisms
- Radioactivity and Radon Measurements
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Spectroscopy and Laser Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Medication Adherence and Compliance
- Autophagy in Disease and Therapy
- ZnO doping and properties
Huazhong University of Science and Technology
2016-2024
First Affiliated Hospital of Gannan Medical University
2024
Beijing Chao-Yang Hospital
2019-2023
Capital Medical University
2019-2023
Union Hospital
2016-2023
Huadong Hospital
2023
Fudan University
2023
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2013-2022
PLA Air Force Aviation University
2020-2022
Research Institute of Petroleum Exploration and Development
2022
Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) novel discovery strategy selective protein degradation from within cells.
Abstract The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly functionally diverse along their anterior–posterior superficial-deep axes. Here, we find that anterior BLA (aBLA) posterior (pBLA) innervate deep-layer calbindin1-negative (Calb1−) superficial-layer calbindin1-positive neurons (Calb1+) in vCA1, respectively. Photostimulation of pBLA–vCA1 inputs has an anxiolytic effect mice, promoting approach behaviours during conflict exploratory tasks. By contrast,...
Glycogen synthase kinase-3β (GSK-3β) is one of the most effective kinases in promoting tau hyperphosphorylation and accumulation Alzheimer's disease (AD). However, it not clear how GSK-3β activity regulated during AD progression.We firstly used mass spectrometry to identify acetylation site GSK-3β, then established cell animal models acetylation. Next, we conducted molecular, biological behavioral tests. Finally, designed a peptide test whether blocking tau-mediated could be beneficial AD.We...
Reactive oxygen species (ROS) are believed to play a major role in the proinflammatory, M1-polarized form of neuroinflammation. However, it has been difficult assess ROS and their neuroinflammation animal models disease because absence probes capable measuring presence with functional imaging technique positron emission tomography (PET). This study describes synthesis vivo evaluation [18F]ROStrace, radiotracer for superoxide PET, an LPS model [18F]ROStrace was found rapidly cross blood–brain...
Abstract Olanzapine is a second-generation anti-psychotic drug used to prevent neuroinflammation in patients with schizophrenia. However, the long-term administration of olanzapine leads insulin resistance (IR); mechanisms this effect remains poorly understood. Using cellular and rodent models IR induced by olanzapine, we found that chronic treatment induces differential inflammatory cytokine reactions peripheral adipose central nervous system. Long-term caused metabolic symptoms, including...
Increasing evidence suggests that glycogen synthase kinase-3β (GSK-3β) plays a crucial role in neurodegenerative/psychiatric disorders, while pan-neural knockout of GSK-3β also shows detrimental effects. Currently, the function specific type neurons is elusive. Here, we infused AAV-CaMKII-Cre-2A-eGFP into GSK-3βlox/lox mice to selectively delete kinase excitatory hippocampal dentate gyrus (DG), and studied effects on cognitive/psychiatric behaviors molecular mechanisms. We found with...
Abstract Background Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which closely related to tau pathology and hippocampal impairment. Due the heterogeneity brain neurons, specific roles different neurons in terms their sensitivity accumulation contribution AD-like social remain unclear. Therefore, further investigation necessary. Methods We investigated effects by Tandem mass tag proteomic phosphoproteomic analysis, behavioural tests,...
The low-frequency optical and dielectric properties of ZnO tetrapod structures prepared by thermophysical method were studied terahertz time-domain spectroscopy. power absorption, refractive index, the complex function measured in frequency range from 0.2to3.5THz. Based on a simple effective medium theory, tetrapods found to be associated with transverse E1 phonon mode, which is consistent that observed bulk single-crystal ZnO.
The ultrafast lasing dynamics of single zinc oxide nanowires are studied by time-resolved upconversion the emission as a function ultraviolet excitation intensity. Induction times for stimulated in individual observed to be 1−5 ps or 3−15 roundtrips nominal 20 μm long nanowires, depending on 267 nm In separate experiments, transient absorption profiles also obtained time-delayed 800 and 400 pulses elucidate carrier dynamics, such rapid decay (2−3 ps) electron−hole plasma (EHP) states at high...
A new class of vesicular acetylcholine transporter inhibitor that incorporates a carbonyl group into the benzovesamicol structure was synthesized, and analogues were evaluated in vitro. (+/-)-trans-2-Hydroxy-3-(4-(4-[(18)F]fluorobenzoyl)piperidino)tetralin (9e) has K(i) values 2.70 nM for VAChT, 191 sigma(1), 251 sigma(2). The racemic precursor (9d) resolved via chiral HPLC, (+/-)-[(18)F]9e, (-)-[(18)F]9e, (+)-[(18)F]9e respectively radiolabeled microwave irradiation appropriate precursors...
A series of microPET imaging studies were conducted in anesthetized rhesus monkeys using the dopamine D₃-selective partial agonist, [¹⁸F]5. There was variable uptake regions brain known to express a high density D₃ receptors under baseline conditions. Pretreatment with lorazepam (1 mg/kg, i.v. 30 min) reduce endogenous activity before tracer injection resulted dramatic increase caudate, putamen, and thalamus, an binding potential (BP) values, measure receptor vivo. These data indicate that...
Abstract Background Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration Alzheimer’s disease (AD). This study aimed to investigate whether how the accumulating may turn affect autophagy. Methods The primary hippocampal neurons, N2a HEK293T cells with overexpression were respectively starved treated vinblastine effects of on initiating steps autophagy, which was analysed by Student's two-tailed t -test. rapamycin concanamycin A employed inhibit mammalian target...
Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark Alzheimer's disease (AD). However, mouse models imitating AD-exclusive neuronal pathologies are lacking.
The ultrafast lasing dynamics of single zinc oxide nanotetrapods and nanowires are investigated by two-color femtosecond excitation/optical injection spectroscopy. transient spectral gain induced time-delayed optical pulses (400 nm) is used to investigate the spectrally temporally resolved properties in a tetrapod or nanowire laser excited 267-nm pulses. output pulse exhibits faster decay time than carrier decays due superlinear dependence on density. Lasing at low-energy side bandwidth (392...
Fault detection in heating, ventilation and air-conditioning (HVAC) systems can effectively prevent equipment damage system energy loss, enhance the stability reliability of operation. However, existing fault strategies have not realized high effectiveness, mainly due to time-delay characteristics HVAC faults lack system-fault operation data. Therefore, aiming at time delay actual data, this paper proposes a method that combines simulation model an intelligent algorithm. The first uses...
The implementation of the NVBP policy has generated considerable reductions in drug procurement prices and an increase market share drugs.This study aimed to investigate patients' attitudes towards switching drugs national volume-based (NVBP) identify their underlying influencing factors Wuhan, China.A total 21 eligible patients from Wuhan Union Hospital who were switched between January 2022 May included our study. Semi-structured face-to-face interviews conducted collect interview...
Adult hippocampal neurogenesis (AHN) deficits contribute to the progression of cognitive impairments during accelerated senescence, with mechanistic causes poorly understood. Glycogen synthase kinase-3β (GSK-3β) is a critical regulator in prenatal neurodevelopment. The present study aims whether and how GSK-3β regulates AHN senescence. Methods: AHN-dependent cognition were evaluated 3- 6-month senescence-accelerated mice prone 8 (SAM-P8) senescence resistant 1 (SAM-R1) mice, respectively....
Abstract Background Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer’s disease (AD). However, sensitivity neurons to AD-like strategies ameliorate tau-disrupted spatial memory terms neural circuits still remain elusive. Methods To investigate effect mechanism circuit Alzheimer's disease-related hippocampal memory, overexpression human wild-type Tau (hTau) medial septum (MS)-hippocampus (HP) was achieved by specifically...