A5102839704- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Insect Resistance and Genetics
- Pain Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Analytical Chemistry and Chromatography
- Studies on Chitinases and Chitosanases
- interferon and immune responses
- Drug Transport and Resistance Mechanisms
- Pancreatic and Hepatic Oncology Research
- Silkworms and Sericulture Research
- Cancer-related gene regulation
- Diabetes Management and Education
- Advanced Glycation End Products research
- Viral Infectious Diseases and Gene Expression in Insects
- Stress Responses and Cortisol
- Protein Interaction Studies and Fluorescence Analysis
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
- Pharmacological Receptor Mechanisms and Effects
- Cytokine Signaling Pathways and Interactions
- Mosquito-borne diseases and control
Second Hospital of Shandong University
2019-2020
Peking University First Hospital
2013
Peking University
2013
BACKGROUND:Cerebral ischemia-reperfusion injury is a pivotal cause of deaths due to cerebrovascular accident. Increased research efforts are needed reveal the mechanism underlying its aggravation or alleviation. In this study, effects dexmedetomidine post-conditioning on HMGB1/TLR4/NF-κB signaling pathway in cerebral rats was explored. MATERIAL AND METHODS:Ninety were randomly divided into 5 groups – sham group (Sham), model (I/R), (Dex), recombinant high mobility protein B1 (rHMGB1), and...
BACKGROUND Brain-derived neurotrophic factor (BDNF) is one of the factors that modulate critical metabolic activities, including apoptosis, proliferation, and differentiation modulation. Although numerous studies have focused on damaging effects BDNF neurons, underlying relationship between these remains unclear. In present study, we investigated protective effect neuronal injury induced by ropivacaine assessed whether it related to Akt signaling pathway. MATERIAL AND METHODS Human...
Objective: To study the effects of sevoflurane on reproductive function and its main mechanism action in male rats.Materials methods: Forty adult Sprague-Dawley rats were divided into 4 groups exposed to 0, 50, 300 1800 ppm sevoflurane, respectively. After 15 days, serum levels sex hormones inflammatory factors detected using enzyme-linked immunosorbent assay. Left testis was taken for conventional histopathological examination TUNEL staining. Right used sperm production daily count...
Introduction Studies have suggested a potential association between patients who both psoriasis and diabetes liver damage. However, the exact nature of this link has not yet been fully established. The objective current study was to examine exacerbation damage due coexistence type 2 mellitus (T2DM) explore impact interferon gene stimulating factor (STING) on related Material methods Four patient groups were recruited: normal individuals, individuals with diabetes, those psoriasis, psoriasis....
Objective To determine the role of epidermal growth factor receptor (EGFR) in mediating epithelial-mesenchymal transition (EMT) pancreatic cancer cells (PANC-1).Methods PANC-1 were transfected with small interfering RNA EGFR using a lentiviral expression vector to establish an EGFR-knockdown cell line (si-PANC-1).PANC-1 expressing negative control sequence used as (NC-PANC-1).Scratch assay and Transwell analyze migration invasion.Real-time polymerase chain reaction (PCR) Western blotting...