A5073479976- Myasthenia Gravis and Thymoma
- RNA modifications and cancer
- Circular RNAs in diseases
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Thyroid and Parathyroid Surgery
- RNA Research and Splicing
- Extracellular vesicles in disease
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Single-cell and spatial transcriptomics
- Neuroblastoma Research and Treatments
- Aerosol Filtration and Electrostatic Precipitation
- Cancer-related molecular mechanisms research
- Vascular Malformations and Hemangiomas
- Peripheral Neuropathies and Disorders
Zhongshan Hospital
2015-2025
Sun Yat-sen University
2013-2025
Fudan University
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2013-2025
Centre for Human Genetics
2022-2025
University of Oxford
2022-2025
Broad Institute
2025
Chinese Institute for Brain Research
2025
Beijing Normal University
2025
Renmin Hospital of Wuhan University
2024
Abstract Layered transition metal oxides are appealing cathodes for sodium‐ion batteries due to their overall advantages in energy density and cost. But stabilities usually compromised by the complicated phase oxygen redox, particularly when operating at high voltages, leading poor structural stability substantial capacity loss. Here an integrated strategy combing high‐entropy design with superlattice‐stabilization extend cycle life enhance rate capability of layered is reported. It shown...
Abstract Background The Th17 subset and IL-17 have been found in increased frequencies within certain tumors. However, their relevance cancer biology remains controversial. This study aimed to clarify the biological action of on hepatocellular carcinoma (HCC). Methods Effects underlying molecular mechanisms human HCC were explored vitro using exogenous stimulation nude mice by implanting overexpressed cells. clinical significance was investigated tissue microarrays containing tissues from...
Cell-free circulating tumor DNA (ctDNA) in plasma has been used as a potential noninvasive biomarker for various tumors. Our study was performed to evaluate the clinical implications of ctDNA detection patients with metastatic pancreatic cancer. First, we attempted prospectively screen panel 60 genes cell-free (cfDNA) from ten cancer via exome sequencing. Second, droplet digital PCR (ddPCR) identify mutations cohort 188 Finally, preliminary role monitoring responses following chemotherapy,...
Although success was achieved in the therapy for a minority of advanced lung adenocarcinoma (LUAD) patients, anti-programmed death 1 (PD1) resistance found most LUAD patients. Here, we aimed to uncover potential role exosomal circular RNAs (circRNAs) refractory PD1 blockade. METHODS: circRNA sequencing and qRT-PCR were performed determine level circRNAs patients subsequently treated with anti-PD1. Then, RNA pulldown, immunoprecipitation, mass spectrometry, chromatin luciferase reporter...
MYB transcription factors are involved in many biological processes, including metabolism, development and responses to biotic abiotic stresses. RADIALIS-LIKE SANT/MYB 1 (RSM1) belongs a MYB-related subfamily, previous transcriptome analysis suggests that RSM1 may play roles plant development, stress hormone signaling. However, the molecular mechanisms of action response stresses remain obscure. We show down-regulation or up-regulation expression alters sensitivity seed germination cotyledon...
Clear cell renal carcinoma (ccRCC) is a major worldwide health problem due to its high prevalence and mortality rate. A disintegrin metalloproteinase 12 (ADAM12) aberrantly expressed in various cancers plays an important role tumor progression. However, explicit effect molecular mechanism ccRCC remain unclear.We investigated the dysregulation of ADAM12 through public databases bioinformatics analyses. The expression was further verified tissues by RT-qPCR immunohistochemistry (IHC)....
Coronary artery disease (CAD), the leading cause of death worldwide, is influenced by both environmental and genetic factors. Although over 250 risk loci have been identified through genome-wide association studies, specific causal variants their regulatory mechanisms are still largely unknown, particularly in disease-relevant cell types such as macrophages.
Background Rapamycin is an attractive approach for the treatment and prevention of HCC recurrence after liver transplantation. However, objective response rates rapamycin achieved with single-agent therapy were modest, supporting that resistance a frequently observed characteristic many cancers. Some studies have been devoted to understanding mechanisms resistance, however, are cell-type-dependent on in extremely limited. Methodology/Principal Findings The anti-tumor sensitivity was modest...
Purpose:The aim of this study was to compare diagnostic accuracy between CT and MRI for thymic masses. Methods:We searched literature collected information on first author, publication year, cases different types lesions, correct results quantitative analysis MRI.The ROC curve applied the performance imaging modalities.Results: Eight literatures were finally included analyzed in study.There 253 examined by 340 total.We showed outcomes each article.The sensitivity both 100%, while specificity...
The scavenger receptor CD36 was reported to be highly expressed on tumor-infiltrating CD8+ T cells, but the clinical role remains obscure. This study aims explore infiltration and value of CD36+CD8+ cells in NSCLC.Immunohistochemistry immunofluorescence were conducted for survival analyses immunological evaluation 232 NSCLC patients Zhongshan Hospital. Flow cytometry carried out assess immune from fresh tumor samples, non-tumor tissues peripheral blood. In vitro infiltrating lymphocytes...
Abstract Oxidative stress strongly influences the pathophysiology of erectile dysfunction (ED). In this study, we used oxidative balance score (OBS), a composite index, to measure effects triggered by diet and lifestyle factors. Here, conducted cross-sectional study determine statistical relationship between OBS ED among adult males in U.S. The data from 3318 participants National Health Nutrition Examination Survey (NHANES) 2001–2004 were analyzed. Weighted logistic regression was correct...
Virus-induced hepatocarcinogenesis involves a series of histological developmental processes with the stepwise acquisition several genetic changes that are necessary for malignant transformation hepatocytes. Although alterations known to be involved in pathogenesis hepatocellular carcinoma (HCC), little is about contributions specific genes this process. To gain insight into neoplastic evolution from chronic hepatitis B virus infection dysplastic nodules (DN) HCC, we captured and sequenced...
Abstract Hepatocellular carcinoma (HCC) is a highly malignant tumor characterized by rapid progression, poor prognosis, and frequent hematogenous metastasis. A minimally invasive diagnostic biomarker that can predict disease progression treatment response would be of extraordinary benefit. Therefore, we have investigated whether the number circulating cells (CTCs) correlated with in HCC. Here report CTCs, monitored vivo flow cytometry (IVFC), strongly metastatic orthotopic nude mouse model...
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors. Eukaryotic translation initiation factors 3B (EIF3B) considered to influence tumor proliferation, invasion, apoptosis and cycle, which act together promote progression However, role EIF3B in ESCC unknown. This study aims explore clinical biological ESCC.EIF3B expressions were up-regulated both tissues lines. Overexpression was associated with depth, lymph node metastasis advanced TNM stage. Importantly,...
Glioma is the most common and malignant primary brain tumour in adults has a dismal prognosis. Temozolomide (TMZ) only clinical first-line chemotherapy drug for glioma up to present. Due poor aqueous solubility toxic effects, TMZ still inefficient limited treatment.UiO-66-NH2 nanoparticle zirconium-based framework, constructed by Zr 2-amino-1,4-benzenedicarboxylic acid (BDC-NH2) with octahedral microporous structure, which can be decomposed body into an ionic form discharge. We prepared...
Background Activating signal cointegrator 3 (ASCC3) has been identified as an oncogenic factor that impairs host immune defense. However, the underlying mechanisms of carcinogenesis and its impact on antitumor response remain unclear. In this study, we aimed to investigate molecular ASCC3 in progression non-small cell lung cancer (NSCLC). Methods Single-cell sequencing data from Gene Expression Omnibus gene expression profiles The Cancer Genome Atlas database were analyzed. expression,...
Traditional histological methods for identifying ectopic thymus (ET) have significant limitations including high risk of false negatives. This study aims to evaluate the effectiveness flow cytometry in detecting ETs patients undergoing total thymectomy. We analyzed 864 samples from 103 using and hematoxylin eosin (H&E) staining. were identified by presence CD3mediumTCRvβmediumCD4+CD8+ T cells or Hassall's corpuscles H&E In discovery set, detected 69.2% samples, compared 23.6% methods. The...
Classroom teaching is essential for cognitive development and cultural evolution, yet its neurocognitive mechanisms remain unclear. Here, this explored in a university graduate course by combining wearable functional near-infrared spectroscopy (fNIRS) machine learning models. The results show that blended involving both students' recalling teachers' lecturing leads to better outcomes than alone. Moreover, during the same phase, induces knowledge construction middle frontal cortex (MFC),...
Abstract OBJECTIVES This study aimed to explore the possibility of positron emission tomography/computed tomography (PET-CT) in identifying histological classification thymic tumors. METHODS Patients diagnosed as tumors and accepted PET-CT scans were included. Thymic classified into three subgroups: low risk thymoma (A, AB B1), high (B2, B3) carcinoma (TC). Logistic regression analysis was performed identify potential factors differentiating The Receiver Operating Curve applied assess...
Purpose of review Macrophages can accumulate lipid droplets in their cytoplasm resulting the foamy appearance seen various diseases, especially atherosclerosis. This assesses new insights from single cell analyses into role different human macrophage subpopulations and genetic risk atherosclerotic disease. Recent findings Single transcriptomic studies have identified TREM2hi macrophages as a key population both mouse plaques. In addition, TREM1hi/PLIN2hi plaques has pro-inflammatory...