A5032846721- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Veterinary Medicine and Surgery
- Veterinary Oncology Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Human-Animal Interaction Studies
- Xenotransplantation and immune response
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Pancreatitis Pathology and Treatment
- Growth Hormone and Insulin-like Growth Factors
- T-cell and B-cell Immunology
- Clinical practice guidelines implementation
- Pancreatic and Hepatic Oncology Research
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Thyroid Disorders and Treatments
- RNA modifications and cancer
- Delphi Technique in Research
- Veterinary Equine Medical Research
- Regulation of Appetite and Obesity
- Virus-based gene therapy research
- MicroRNA in disease regulation
University of Oxford
2013-2025
Royal Veterinary College
2005-2025
Centre for Human Genetics
2013-2025
Royal College of Physicians and Surgeons of Canada
2002-2024
University of London
2020
University of Cambridge
1998-2018
Queen's Hospital
2005-2017
Juvenile Diabetes Research Foundation
2011-2012
Addenbrooke's Hospital
2011-2012
Wellcome Trust
2011-2012
GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. activation involved inflammatory response but mechanisms by which it modulates inflammation have incompletely described. In this study, we investigated expression, function macrophages to establish role during response. We observed that murine tissues increased endotoxemia, hyperglycemia hypercholesterolemia. Ex vivo studies revealed mRNA LPS other...
Abstract Insulinoma is the most common pancreatic tumor diagnosed in dogs. This study aimed to report incidence risk, breed predispositions and other demographic risk factors for insulinoma dogs under primary veterinary care UK. The VetCompass Program supports research on anonymized electronic health records (EHRs) from UK care. included all EHRs during 2019. Multivariable logistic regression analysis was used evaluate diagnosis. Of 2,250,741 dogs, 278 were confirmed as cases at any date....
Clinical information and blood samples were collected from 253 dogs with naturally occurring diabetes mellitus. Over half of them labrador retrievers, collies, Yorkshire terriers or crossbred dogs, approximately 80 per cent diagnosed between the ages five 12 years. The majority receiving insulin therapy once a day, but in injections twice day there was trend for lower serum fructosamine concentrations, suggesting better glycaemic control. proportion female than previous surveys. disease more...
The chromosome 16p13 region has been associated with several autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). CLEC16A reported as the most likely candidate gene in region, since it contains disease-associated single-nucleotide polymorphisms (SNPs), well an imunoreceptor tyrosine-based activation motif. However, here we report that intron 19 of CLEC16A, containing SNPs, appears to behave a regulatory sequence, affecting expression neighbouring gene, DEXI....
A causative role for single nucleotide polymorphisms (SNPs) in many genetic disorders has become evident through numerous genome-wide association studies. However, identification of these common causal variants and the molecular mechanisms underlying associations remains a major challenge. Differential transcription factor binding at SNP resulting altered gene expression is one possible mechanism. Here we apply PWAS ("proteome-wide analysis SNPs"), methodology based on quantitative mass...
Coronary artery disease (CAD), the leading cause of death worldwide, is influenced by both environmental and genetic factors. Although over 250 risk loci have been identified through genome-wide association studies, specific causal variants their regulatory mechanisms are still largely unknown, particularly in disease-relevant cell types such as macrophages.
Abstract Diabetes mellitus occurs spontaneously in dogs, which is believed to have an autoimmune component and be a model of human latent diabetes adults (LADA). Some dog breeds (e.g. Samoyed) are particularly predisposed, whereas others Boxer) highly resistant. With the completion Dog Genome Assembly, comparative genomic studies complex diseases including diabetes, could provide important investigative approach into such disorders. Type 1 humans strongly associated with major...
Despite decades of research in humans and mouse models disease, substantial gaps remain our understanding pathogenic mechanisms underlying the development type 1 diabetes. Furthermore, translation therapies from preclinical efforts capable delaying or halting β-cell destruction has been limited. Hence, a pressing need exists to identify alternative animal that reflect human disease. Canine insulin deficiency diabetes is, some cases, considered follow autoimmune pathogenesis, similar NOD mice...
Abstract Background Diabetes mellitus (DM) is an important endocrine disorder of dogs. The objectives this study were to estimate prevalence and incidence DM in dogs, explore risk factors for the survival cases primary-care clinics UK. Results A case-control nested cohort dogs ( n = 480,469) aged ≥3 years presenting at 430 VetCompass was used identify DM, using multivariable logistic regression. Overall 409 new 863 pre-existing (total 1272) identified 2016, giving apparent annual 0.26% (95%...
OBJECTIVE IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide association (GWA) studies have linked a region 3′-UTR with C-ALL susceptibility, we tested whether is associated autoimmune disease type 1 diabetes. RESEARCH DESIGN AND METHODS rs10272724 (T>C) near at 7p12 was genotyped 8,333 individuals diabetes, 9,947 control subjects, 3,997...
Remarkably little has been published on hematological phenotypes of the domestic dog, most polymorphic species planet. Information signalment and complete blood cell count all dogs with normal red white parameters judged by existing reference intervals was extracted from a veterinary database. Normal profiles were available for 6046 dogs, 5447 which also had machine platelet concentrations within interval. Seventy-five pure breeds plus mixed breed control group represented 10 or more dogs....
Abstract Background Diabetes mellitus (DM) is an important endocrine disorder in dogs. This study explored prior exposure to glucocorticoids or antibiotic treatment as risk factors for developing DM dogs attending primary‐care VetCompass clinics the UK. Methods A breed frequency matched case–control nested a cohort of ( n = 480,469) aged 3 years over was used explore associations between glucocorticoid and odds DM. Results total 565 cases 2179 controls were included. Dogs with had four times...
Stomatocytosis is a rare spectrum of red blood cell (RBC) disorders. In humans, stomatocytosis typically caused by genetic changes in specific ion exchange and transport genes. has been identified dogs, however the underlying causes are unknown. Recently, was reported Beagle Australian Cattle Dog for first time. Here, whole-genome sequencing (WGS) these dogs undertaken to identify candidate variants driving or impacting stomatocytosis. Cases were compared WGS 119 controls several breeds >...
The generation of a blood glucose curve is important for assessing the response to insulin therapy in diabetic dogs. Disadvantages this technique include patient discomfort and potential missing transient hypo‐ or hyperglycaemic episodes. aim current study was evaluate continuous monitoring system (CGMS) use Interstitial fluid concentrations were recorded 10 dogs, every five minutes up 48 hours, using subcutaneous sensor attached CGMS device. Blood measured simultaneously glucometer....
The cancer microenvironment plays a pivotal role in oncogenesis, containing number of regulatory cells that attenuate the anti-neoplastic immune response. While negative prognostic impact T (Tregs) context most solid tissue tumors is well established, their lymphoid malignancies remains unclear. expressing FOXP3 and Helios were documented fine needle aspirates affected lymph nodes dogs with spontaneous multicentric B cell lymphoma (BCL), proposed to be model for human non-Hodgkin lymphoma....
Abstract Canine malignant insulinoma is a rare, highly metastatic and life-threatening neuroendocrine tumour of pancreatic beta cells. To map the single-cell transcriptomic landscape canine for first time, profiles 5,532 cells were captured from two spontaneous insulinomas (Patient 1 2) one associated metastasis in Boxer dogs. Distinct cancer, endocrine, immune cell populations identified. Notably, all three samples contained transcriptionally distinct insulin-expressing (INS + INS FOS low...
O bjectives : To determine the value of inhaled corticosteroids in management chronic inflammatory airway disease dogs. M ethods Medical records dogs that were presented for investigation respiratory reviewed retrospectively. Criteria inclusion knowledge previous medical treatment including side effects, diagnosis underlying disease, use and at least two‐months follow‐up data. R esults Thirteen fulfilled criteria identified. Ten diagnosed with bronchitis three eosinophilic...