A5103237787- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Phagocytosis and Immune Regulation
- Nanoparticles: synthesis and applications
- Monoclonal and Polyclonal Antibodies Research
- Polymer Surface Interaction Studies
- Carbon Nanotubes in Composites
- Glutathione Transferases and Polymorphisms
- T-cell and B-cell Immunology
- Porphyrin and Phthalocyanine Chemistry
- Micro and Nano Robotics
- Hydrogels: synthesis, properties, applications
- Genomics, phytochemicals, and oxidative stress
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
- RNA modifications and cancer
- Ginseng Biological Effects and Applications
Royal Veterinary College
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen University
2017-2023
Institute of Biomedical Science
2015-2020
Peking Union Medical College Hospital
2015-2020
Shaanxi University of Chinese Medicine
2019
Second Military Medical University
2017
King's College London
2017
Medical Research Council
2017
Abstract The regulation of tumor immunosuppressive microenvironments via precise drug delivery is a promising strategy for preventing recurrence and metastasis. Inspired by the stealth strategy, stealthy nanovehicle based on neutrophil camouflage developed to achieve immunotherapy triggering pyroptosis. comprises anti‐CD11b‐ IR820‐conjugated bovine serum albumin nanoparticles loaded with decitabine. Camouflaged neutrophils, nanovehicles efficient hitchhiking owing biotropism neutrophils...
Controllable and visible delivery of therapeutic agents is critical for tumor precise therapy. Tumor targeting deep penetration are still challenging issues controllable delivery. Visible drug with imaging navigation can optimize the treatment window personalized medicine. Herein, a biomimetic platelet intelligent vehicle (IRDNP-PLT) was developed to achieve system, driving loading system. The platelets acted as engines repositories exert target functions. fluorescent photothermal agent...
Abstract Tumor precision therapy and preventing tumor recurrence metastasis are the main challenges to eradication. Herein, an apoptotic body‐based vehicle with imaging navigation is developed for precise delivery photothermal‐immunotherapy by IR820‐conjugated body loaded R848 nanoparticles. The serves as ammunition stores well drive engines, while IR820 acts a fluorescence photothermal controlling system. can deliver achieve deep penetration macrophage‐hitchhiking. Fluorescence opens...
During wound healing after cancer surgery, platelets, neutrophils, and macrophages accumulate at the site induce important pathophysiological features. Utilizing these features, development of targeted delivery systems for postoperative tumor immunotherapy is an strategy. Herein, a twindrive precise system hybrid membrane combined with CD47 blocking developed regulation to immunotherapy. The consists IR820-modified platelet-neutrophil membranes loaded R848 nanoparticles. Based on...
Abstract Nanomedicine has reshaped the landscape of cancer treatment. However, its efficacy is still hampered by innate tumor defense systems that rely on adenosine triphosphate (ATP) for fuel, including damage repair, apoptosis resistance, and immune evasion. Inspired naturally enzymatic reaction glucose oxidase (GOx) with glucose, here a novel “two birds one stone” technique amplifying enzyme‐mediated enzyme‐promoted metabolic clearance proposed achieved using GOx‐functionalized rhenium...
Fluorescence imaging in vivo will pave an important way for the evaluation of biomaterials. The major advantage fluorescence compared to other modalities is possibility tracking two or more probes simultaneously with multispectral imaging. It essential elucidate location, erosion, drug release and resection implanted biomaterials vivo. Herein, a thermosensitive hydrogel protoporphyrin core based on PEG PCL copolymer (PCL–PEG–PPOR–PEG–PCL) was synthesized by ring-opening polymerization using...
Codelivery nanovaccines of antigens and adjuvants have achieved positive therapy for cancer immunotherapy. The insufficient immunogenicity these vaccines leads to the difficulty eliciting robust immune effects clearance due inadequate loading efficiency, complex preparation processes, low safety concerns, weak responses. Herein, a visible codelivery nanovaccine an antigen adjuvant based on self-cross-linked nanoparticles (ovalbumin (ONPs)) combined with (CpG) immunotherapy was prepared using...
Abstract Pyroptosis‐based immunotherapy can escape drug resistance as well inhibit metastasis. It is urgently required to develop a delivery platform induce targeted tumor‐specific pyroptosis for cancer immunotherapy. Herein, macrophages‐based biohybrid microrobots (IDN@MC) are constructed with IR‐macrophage and decitabine‐loaded Metal‐organic frameworks (DZNPs). The integration of fluorescence photosensitizers pH‐sensitive DZNPs endow the properties such photothermal conversion, fluorescent...
Abstract Modification of carbon nanotubes (CNTs) with carboxyl group is one the widely used strategies to increase their water dispersibility. Various molecules can be further coupled surface carboxylated CNTs for desired applications. However, effect carboxylation on cytotoxicity far from being completely understood. In this study, impact multiwalled CNT (MWCNT‐COOH) human normal liver cell line L02 was studied and compared pristine (p‐MWCNT). The data accumulated in study revealed that...
The combination of an antigen and adjuvant has synergistic effects on immune response. Coadministration a granulocyte-macrophage colony-stimulating factor (GM-CSF) hydrogel delivery system will afford novel strategy for enhancement response because the dual role as vaccine carrier with sustained release platform recruiting dendritic cells (DCs). Herein, injectable poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone) thermosensitive coencapsulating GM-CSF ovalbumin nanoparticles was...
Monitoring drug release and therapeutic efficacy is crucial for developing delivery systems. Our preliminary study demonstrated that, as compared with pristine multiwalled carbon nanotubes (MWCNTs), transactivator of transcription (TAT)-chitosan functionalized MWCNTs (MWCNTs-TC) were a more promising candidate in cancer therapy. In the present study, MWCNTs/TC-based system was developed an anticancer drug, doxorubicin (DOX). The loading vitro profiles, cellular uptake cytotoxicity assessed....
Visualization of a drug delivery system could reveal the pharmacokinetic properties, which is essential for design novel system. In vivo optical imaging offers an advanced tool to monitor release process and therapeutic effect by combination fluorescence bioluminescence imaging. Multispectral can separate carrier without interference. Herein, dual fluorescent anti-tumor was monitored with doxorubicin-loaded hydrogel further explore application porphyrin-incorporated four-arm PEG-PCL...
Collectin-11 (CL-11) is a recently described soluble C-type lectin that has distinct roles in embryonic development, host defence, autoimmunity, and fibrosis. Here we report CL-11 also plays an important role cancer cell proliferation tumor growth. Melanoma growth was found to be suppressed Colec11–/– mice s.c. B16 melanoma model. Cellular molecular analyses revealed essential for proliferation, angiogenesis, establishment of more immunosuppressive microenvironment, the reprogramming...
DOX and CpG loaded MWCNT with NIR irradiation could destroy tumor cells by photothermal chemotherapy release tumor-associated antigens, thus generating melanoma specific immune response to achieve synergistic therapeutic effect.
Real-time tracking of a drug delivery system and its therapeutic effects in vivo are crucial to designing novel pharmaceutical revealing the mechanism therapy. Multispectral fluorescence imaging can locate carrier simultaneously without interference. This advanced method enables system. Herein, doxorubicin (Dox) loaded zinc phthalocyanine incorporated hydrogel was developed as dual fluorescent monitor release degradation carrier. An injectable thermosensitive based on four-arm poly(ethylene...