A5076014187- Veterinary Orthopedics and Neurology
- Veterinary Oncology Research
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Hereditary Neurological Disorders
- Lysosomal Storage Disorders Research
- Veterinary Equine Medical Research
- Glycogen Storage Diseases and Myoclonus
- Spinal Dysraphism and Malformations
- Infectious Encephalopathies and Encephalitis
- Monoclonal and Polyclonal Antibodies Research
- Spine and Intervertebral Disc Pathology
- Dermatological and Skeletal Disorders
- Human-Animal Interaction Studies
- Neuroscience of respiration and sleep
- Neurological diseases and metabolism
- Congenital Anomalies and Fetal Surgery
- Cellular transport and secretion
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Herpesvirus Infections and Treatments
- Veterinary Pharmacology and Anesthesia
- Virus-based gene therapy research
- Studies on Chitinases and Chitosanases
- Alkaline Phosphatase Research Studies
Willows Veterinary Centre and Referral Service
2020-2024
University of Cambridge
2013-2019
University of Granma
2016
Queen's Hospital
2014
American College of Medical Genetics
1999
Intranasal administration of benzodiazepines has shown superiority over rectal for terminating emergency epileptic seizures in human trials. No such clinical trials have been performed dogs.To evaluate the efficacy intranasal midazolam (IN-MDZ), via a mucosal atomization device, as first-line management option canine status epilepticus and compare it to diazepam (R-DZP) controlling before intravenous access is available.Client-owned dogs with idiopathic or structural epilepsy manifesting...
Metabolic/neurodegenerative encephalopathies encompass a wide list of conditions that share similar clinical and magnetic resonance imaging (MRI) characteristics, challenging the diagnostic process resulting in numerous tests performed order to reach definitive diagnosis. The aims this multicentric, retrospective descriptive study are: (I) describe MRI features dogs cats with metabolic/neurodegenerative encephalopathies; (II) attempt an recognition pattern classifying these according...
Infectious meningoencephalitides represent an important differential diagnosis for meningoencephalitis of unknown origin (MUO) in dogs. Treatment the latter requires immunosuppression, but laboratory test results infectious agents may take several days to return. This study investigated whether presence masticatory muscle changes on magnetic resonance imaging (MRI) head can be used distinguish dogs with neosporosis from those MUO at time diagnosis. Cases diagnosed or two referral centers...
Myokymia is a form of peripheral nerve hyperexcitability that can be focal or generalized. Information regarding myokymia in veterinary medicine currently limited, resulting need for better understanding this clinical sign. Describe the presentation, diagnostic findings, treatment, and outcomes dogs cats with facial (FM). Seven two clinically confirmed FM. Retrospective study. Clinical records from six referral institutions were reviewed to identify cases Signalment, test results, outcome...
CASE DESCRIPTION 5 dogs were examined because of clinical signs myelopathy, including pain associated with the spinal region and rapidly progressive neurologic deficits. CLINICAL FINDINGS In all dogs, results MRI consistent epidural empyema. Concurrent infectious processes identified at adjacent or distant sites in diskospondylitis, prostatitis, dermatitis, paraspinal infection following a penetrating injury, urinary tract infection, pyothorax. Bacteria isolated from 3 dogs; Escherichia coli...
A 4-month-old female entire domestic shorthair cat presented with an acute onset of blindness, tetraparesis and subsequent generalised seizure activity. Haematology serum biochemistry demonstrated a moderate, poorly regenerative anaemia, hypoalbuminaemia hyperglobulinaemia low albumin:globulin ratio. Serology for feline coronavirus antibody was positive elevated alpha-1 acid glycoprotein. Analysis cisternal cerebrospinal fluid (CSF) markedly protein mixed, predominately neutrophilic...
Idiopathic generalized tremor syndrome is a disorder characterized by an acute onset of full-body tremors, sometimes accompanied vestibulo-cerebellar signs, that responsive to treatment with corticosteroids. Although considered have overall good outcome, relapsing and persistent mild clinical signs been described. So far, little known about the etiopathology this syndrome, but it believed immune-mediated origin. In human medicine, description numerous autoantibodies involved in certain...
A 10-month-old, 3 kg, female spayed Domestic Shorthair cat was presented with a chronic, infected wound at the level of proximo-lateral left pelvic limb. General physical examination revealed weight-bearing lameness limb, which moderately and circumferentially swollen edematous proximal to tarsal joint. On lateral aspect thigh, there chronic 1 cm in diameter an additional exudative skin lesion present throughout whole length caudo-lateral thigh. Complete blood count serum biochemistry...
Disorders affecting the control of saccadic eye movements result in involuntary oscillations and are widely reported human medicine. Information regarding occurrence potential importance veterinary medicine is currently limited. The clinical histories three dogs one cat displaying consistent with opsoclonus presented, final diagnoses including idiopathic generalized tremor syndrome neuronal ceroid lipofuscinosis (NCL). A dog closely resembling macrosaccadic also for which a diagnosis NCL was...
Background No evidence‐based guidelines are available for the administration of gadolinium‐based contrast media to veterinary patients. Objective To investigate whether intravenous ( IV ) alters likelihood identifying a brain lesion in dogs and cats. Animals Four hundred eighty‐seven client‐owned animals referred investigation intracranial disease. Methods Two reviewers retrospectively analyzed precontrast transverse sagittal T1‐weighted (T1W), T2‐weighted, fluid‐attenuated inversion...
The aim of the study was to describe signalment, clinical presentation and presumptive or final diagnoses dogs with cranial thoracic spinal cord lesions identified on advanced imaging. Retrospective evaluation databases three veterinary specialty centres, between 2009 2021, performed identify a lesion affecting vertebral column (T1-T6 vertebrae) as primary cause for presenting signs myelopathy and/or pain. Eighty-four were included in study, majority (n = 76) progressive history over...
KCNJ10 and CAPN1 variants cause "spinocerebellar" ataxia in dogs, but their association with generalized myokymia neuromyotonia remains unclear.To investigate the between or neuromyotonia, without concurrent spinocerebellar ataxia.Thirty-three client-owned dogs ataxia, neuromytonia, a combination of these signs.Genetic analysis cohort clinically diagnosed neuromyotonia. c.627C>G c.344G>A coding sequence KCNA1, KCNA2, KCNA6, HINT1 were sequenced using DNA extracted from blood...
ABSTRACT Knowledge regarding the etiology and prognosis for canine megaesophagus (ME) is currently limited to small case series that may now be out of date in light recent advances understanding neurological syndromes availability advanced diagnostic testing. Ninety-nine dogs diagnosed with nonstructural ME were included. Congenital idiopathic was present 10 cases, complete resolution clinical signs a single case. Eighty-nine cases considered acquired, most being either (42.7%) or associated...
Objectives A previous single‐country pilot study indicated serum anti‐GM2 and anti‐GA1 anti‐glycolipid antibodies as potential biomarkers for acute canine polyradiculoneuritis. This aims to validate these findings in a large geographically heterogenous cohort. Materials Methods Sera from 175 dogs clinically diagnosed with polyradiculoneuritis, 112 other peripheral nerve, cranial nerve or neuromuscular disorders 226 neurologically normal were screened against 11 common glycolipid targets...
Infiltration of peripheral nerves distal to the plexus by neoplastic lymphocytes has been rarely reported in dogs; only one previous case report describes B‐cell infiltration femoral nerve. A 4.5‐year‐old female cross‐breed dog presented with a three‐week history tail flaccidity, tenesmus, anorexia and progressive monoparesis right pelvic limb. Ultrasound imaging revealed thickened gastric wall large mass at root mesentery. MRI demonstrated enlargement L6 L7 spinal nerve roots thickening...
Abstract Background Acquired narcolepsy has rarely been reported in veterinary medicine. Objective To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected‐acquired narcolepsy. Animals Eight clinical features consistent acquired Methods A call for suspected cases was made online, followed by a retrospective review detailed medical records potential cases. Dogs were included if episodes cataplexy present during examination...
To assess the utility of Idexx ProCyte Dx® haematology analyser for assessing total nucleated cell count and differential counts in canine cerebrospinal fluid.Seventy-three client-owned dogs undergoing investigations pyrexia and/or neurological signs were prospectively included. Cerebrospinal fluid samples assessed using an results compared to those obtained with external laboratory reference standard.The performed good sensitivity (92.6%) moderate specificity (67.4%) when standard....
Figure S1. Sagittal T2w (A) and transverse T2W (B), T1W (C) post-contrast magnetic resonance images at the level of caudal colliculi demonstrating a isointense (A,B), T1 to normal grey matter markedly contrast-enhancing (D) nodular, well-defined, intra-axial lesion 9.3 mm × 6 within rostroventral aspect cerebellum, resulting in focal narrowing mesencephalic aqueduct this level. Please note: The publisher is not responsible for content or functionality any supporting information supplied by...
Recent work identified anti-GM2 and anti-GalNAc-GD1a IgG ganglioside antibodies as biomarkers in dogs clinically diagnosed with acute canine polyradiculoneuritis, turn considered a equivalent of Guillain-Barré syndrome. This study aims to investigate the serum prevalence similar cats immune-mediated polyneuropathies. The sera from 41 polyneuropathies (IPN), 9 other neurological or neuromuscular disorders (ONM) 46 neurologically normal (CTRL) were examined for presence against glycolipids...