A5033236252- Myasthenia Gravis and Thymoma
- Neurological diseases and metabolism
- Neurogenetic and Muscular Disorders Research
- Hereditary Neurological Disorders
- Veterinary Orthopedics and Neurology
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Veterinary Oncology Research
- Autoimmune Neurological Disorders and Treatments
- Antifungal resistance and susceptibility
- Glycogen Storage Diseases and Myoclonus
- Fungal Infections and Studies
- Ion channel regulation and function
- Neuroendocrine Tumor Research Advances
- Veterinary Equine Medical Research
- Herpesvirus Infections and Treatments
- Tracheal and airway disorders
- Spinal Dysraphism and Malformations
- Genetic Neurodegenerative Diseases
- Neurological and metabolic disorders
- Orthopedic Surgery and Rehabilitation
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Congenital Ear and Nasal Anomalies
University of Cambridge
2013-2025
Wellcome/MRC Cambridge Stem Cell Institute
2024
Queen's Hospital
2011-2023
John Radcliffe Hospital
2016-2020
University of Oxford
2016-2020
Ghent University
2008-2012
Royal Veterinary College
2012
University of London
2012
Geneeskundige en Gezondheidsdienst
2008-2010
Ghent University Hospital
2010
Intranasal administration of benzodiazepines has shown superiority over rectal for terminating emergency epileptic seizures in human trials. No such clinical trials have been performed dogs.To evaluate the efficacy intranasal midazolam (IN-MDZ), via a mucosal atomization device, as first-line management option canine status epilepticus and compare it to diazepam (R-DZP) controlling before intravenous access is available.Client-owned dogs with idiopathic or structural epilepsy manifesting...
The efficacy of anticholinesterase medication may diminish over time. Vanhaesebrouck et al. use an animal model acetylcholine receptor deficiency syndrome to show that beta-2 adrenergic agonists ameliorate the damage neuromuscular junction structure caused by prolonged medication, and thereby counteract decline in efficacy.
Congenital myasthenic syndromes (CMS) are characterized by fatigable muscle weakness resulting from impaired neuromuscular transmission. β2-adrenergic agonists an effective treatment for DOK7-CMS. DOK7 is a component within the AGRN-LRP4-MUSK-DOK7 signalling pathway that key formation and maintenance of synaptic structure junction (NMJ). The precise mechanism action at NMJ not fully understood. In this study, we investigated whether improve both neurotransmission structural integrity in...
Metabolic/neurodegenerative encephalopathies encompass a wide list of conditions that share similar clinical and magnetic resonance imaging (MRI) characteristics, challenging the diagnostic process resulting in numerous tests performed order to reach definitive diagnosis. The aims this multicentric, retrospective descriptive study are: (I) describe MRI features dogs cats with metabolic/neurodegenerative encephalopathies; (II) attempt an recognition pattern classifying these according...
ABSTRACT Background Myasthenia gravis (MG) is categorized into several subgroups, including seronegative MG. Seronegative human patients are well documented, but dogs remain clinically uncharacterized and their prevalence unknown. Objectives This study aims to evaluate the clinical presentation, diagnosis, treatment, outcome of canine MG subgroups. Animals One hundred sixty‐seven owner‐owned diagnosed with from three referral centers. Methods Retrospective case series. We classified...
A 14-year-old male domestic shorthair cat presented with an acute onset of aggressive behaviour, fear and hypersalivation. Neurological examination revealed bilateral mydriasis left-sided facial twitching hemiparesis. Magnetic resonance imaging (MRI) showed moderate symmetrical T2-hyperintensity along the entire hippocampus asymmetric in pyriform lobes. Marked contrast enhancement was evident on post-contrast T1-weighted images. The partial complex seizures were refractory to medical...
To date there is no evidence-based data for efficacious treatment of neuropathic pain in dogs with Chiari-like malformation (CM) and syringomyelia (SM). The objective this prospective cross-over study was to compare the effect gabapentin versus topiramate, as an add-on carprofen, on quality life (QoL) experiencing signs due CM/SM. A visual analogue scale (VAS) used assess QoL: (1) day 0; (2) after 1 week carprofen only; (3) 2 weeks gabapentin; (4) topiramate. No significant difference...
Abstract Background The intranasal (IN) route for rapid drug administration in patients with brain disorders, including status epilepticus, has been investigated. Status epilepticus is an emergency, and the IN offers a valuable alternative to other routes, especially when these fail. Objectives To compare versus IV midazolam (MDZ) at same dosage (0.2 mg/kg) controlling dogs. Animals Client‐owned dogs (n = 44) idiopathic epilepsy, structural or epilepsy of unknown origin manifesting as...
Generalized myokymia and neuromyotonia (M/NM) in Jack Russell Terriers (JRTs) is related to peripheral nerve hyperexcitability syndrome humans, a symptom complex resulting from diverse etiologies.Clinical electrodiagnostic evaluation used narrow the list of possible etiological diagnoses JRTs with M/NM.Nine healthy 8 affected JRTs.A prospective study was conducted comparing clinical electrophysiological characteristics by M/NM 9 JRT controls.All dogs except 1 had signs typical hereditary...
CASE DESCRIPTION 5 dogs were examined because of clinical signs myelopathy, including pain associated with the spinal region and rapidly progressive neurologic deficits. CLINICAL FINDINGS In all dogs, results MRI consistent epidural empyema. Concurrent infectious processes identified at adjacent or distant sites in diskospondylitis, prostatitis, dermatitis, paraspinal infection following a penetrating injury, urinary tract infection, pyothorax. Bacteria isolated from 3 dogs; Escherichia coli...
A 4-month-old female entire domestic shorthair cat presented with an acute onset of blindness, tetraparesis and subsequent generalised seizure activity. Haematology serum biochemistry demonstrated a moderate, poorly regenerative anaemia, hypoalbuminaemia hyperglobulinaemia low albumin:globulin ratio. Serology for feline coronavirus antibody was positive elevated alpha-1 acid glycoprotein. Analysis cisternal cerebrospinal fluid (CSF) markedly protein mixed, predominately neutrophilic...
Key points The physiological significance of the developmental switch from fetal to adult acetylcholine receptors in muscle (AChRs) and functional impact AChR clustering by rapsyn are not well studied. Using patch clamp experiments, we show that recovery desensitization is faster isoform. Recovery determined isoform‐specific cytoplasmic M3–M4 domain. co‐expression cells induced facilitated both AChRs. In AChRs, facilitation kinetics was independent clustering. These effects could be crucial...
Abstract Background Seizures are a common presenting sign in dogs with brain tumors. Hypothesis/Objectives To investigate the effect of radiotherapy on freedom from tumor‐associated seizures and survival time dogs. Animals Thirty‐two client‐owned seizures; 18 received medical treatment radiotherapy, 14 alone. Methods Multicenter retrospective study. Baseline characteristics (seizure semiology, magnetic resonance imaging [MRI] characteristics, treatment) duration seizure were recorded for 2...
To describe the clinical phenotype of a new motor disorder in Labrador Retrievers.Case series study. Seven young male Retrievers presented for evaluation stiff gait.All affected dogs had generalized muscular stiffness, persistent at rest and resulting restricted joint movements. They showed forward flexed posture, festinating gait, bradykinesia. Signs developed between 2 16 months age tended to stabilize adulthood. Needle electromyogram conscious state continuous unit activity resting...
Summary This report describes the management of clinically significant, single level cervical spinal canal stenosis associated with articular facet hypertrophy in a three-year-old Great Dane dog, by combined surgical decompression and stabilization. Spinal column stabilization was achieved ventral application two String Pearls locking plates subsequent accomplished unilateral facetectomy. The six-month postoperative reassessment examination confirmed satisfactory clinical outcome complete...
A 10‐month‐old dachshund was presented with a recent history of episodic muscle rippling and generalised stiffness. An uncoordinated gait present since eight weeks age. On presentation the dog showed cerebellar‐like ataxia poor menace responses. Myokymic contractions were visible in appendicular truncal muscles neuromyotonic discharges detected by electromyography. Central components brain auditory evoked potentials absent onset latencies tibial sensory‐evoked recorded at lumbar...