A5003050755- Water Treatment and Disinfection
- Mass Spectrometry Techniques and Applications
- Myasthenia Gravis and Thymoma
- Ion channel regulation and function
- Cancer, Hypoxia, and Metabolism
- Advanced Chemical Sensor Technologies
- Sulfur Compounds in Biology
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Analytical Chemistry and Chromatography
- Plant responses to water stress
- RNA modifications and cancer
- Forensic Toxicology and Drug Analysis
- Biotin and Related Studies
- Chemical Reactions and Isotopes
- Tailings Management and Properties
- Ubiquitin and proteasome pathways
- Chemical Synthesis and Analysis
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Anesthesia and Sedative Agents
- Pain Mechanisms and Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Odor and Emission Control Technologies
Age UK
2023-2024
GlaxoSmithKline (United Kingdom)
2023
University of Oxford
2013-2020
University of York
2006-2007
Crop yield loss due to flooding is a threat food security. Submergence-induced hypoxia in plants results stabilization of group VII ETHYLENE RESPONSE FACTORs (ERF-VIIs), which aid survival under these adverse conditions. ERF-VII stability controlled by the N-end rule pathway, proposes that N-terminal cysteine oxidation normoxia enables arginylation followed proteasomal degradation. The PLANT CYSTEINE OXIDASEs (PCOs) have been identified as catalysts this oxidation. presumably arises from...
The 2-oxoglutarate (2OG)-dependent Jumonji C domain (JmjC) family is the largest of histone lysine demethylases. There interest in developing small-molecule probes that modulate JmjC activity to investigate their biological roles. 5-Carboxy-8-hydroxyquinoline (IOX1) most potent broad-spectrum inhibitor 2OG oxygenases, including demethylases, reported date; however, it suffers from low cell permeability. Here, we describe structure-activity relationship studies leading discovery an n-octyl...
<h3>Background</h3> A homozygous loss-of-function mutation p.(Arg316Gln) in the <i>fat mass and obesity-associated</i> (<i>FTO</i>) gene, which encodes for an iron 2-oxoglutarate-dependent oxygenase, was previously identified a large family nine affected individuals present with lethal syndrome characterised by growth retardation multiple malformations. To date, no other pathogenic <i>FTO</i> has been as cause of congenital <h3>Methods</h3> We investigated 21-month-old girl who presented...
The efficacy of anticholinesterase medication may diminish over time. Vanhaesebrouck et al. use an animal model acetylcholine receptor deficiency syndrome to show that beta-2 adrenergic agonists ameliorate the damage neuromuscular junction structure caused by prolonged medication, and thereby counteract decline in efficacy.
Background and Purpose Statins are amongst the most widely prescribed drugs for those at risk of cardiovascular disease, lowering cholesterol levels by inhibiting 3‐hydroxy‐3‐methylglutaryl (HMG)‐CoA reductase. Although effective preventing statin use is associated with muscle weakness, myopathies and, occasionally, fatal rhabdomyolysis. As simvastatin, a commonly statin, promotes Ca 2+ release from sarcoplasmic reticulum (SR) vesicles, we investigated if simvastatin directly activates...
Abstract Two opium alkaloids, noscapine and papaverine, show good response as [M+H] + ions in positive ion electrospray mass spectrometry atmospheric pressure chemical ionisation spectrometry. The two compounds exhibit markedly different fragmentation pathways behaviour under multistage (MS n ), with papaverine displaying a wealth of MS 2 providing single dominant at each stage prior to 4 . Elucidation the using capability trap was aided by spraying analytes H O incorporate an isotopic...
In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types eukaryotes and prokaryotes where they act on non HIF substrates. To gain insight into factors underlying different substrates properties, we carried out biochemical biophysical studies from cellular slime mold,
Abstract Benzylpyridine and papaverine, an alkyl quinoline, both produce product ions containing azepinium ring during atmospheric pressure chemical ionisation or electrospray multistage mass spectrometry. By controlling the trapping conditions, isolated ion was held within trap for extended period of time without excitation. A subsequent analytical scan revealed a spectrum at two mass‐to‐charge ( m/z ) ratios, first second ratio corresponding to adduction molecule solvent. Isolation...
Abstract Crop yield loss due to flooding is a threat food security. Submergence-induced hypoxia in plants results stabilisation of group VII ETHYLENE RESPONSE FACTORS (ERF-VIIs), which aid survival under these adverse conditions. ERF-VII stability controlled by the N-end rule pathway, proposes that N-terminal cysteine oxidation normoxia enables arginylation followed proteasomal degradation. The PLANT CYSTEINE OXIDASEs (PCOs) have been identified as catalysts this oxidation. presumably arises...
A model reaction between di‐n‐butylamine and sodium nitrite was studied to investigate trace‐level N ‐nitrosamine formation. Liquid chromatography–mass spectrometry (LC–MS) analysis of kinetic time points from an in‐progress showed a systematic offset in nitrosamine concentration quenched unquenched samples. By combining samples amine the needle autosampler it demonstrated that formed LC–MS system. Further experimentation indicated nitrosation occurring on‐column.
Depending on the mining method being used, required unconfined compressive strength (UCS) of paste fill can vary between 500 to 5000 kPa at 28 days.In order achieve these upper limit UCS targets, high concentration cemented backfill must be placed underground, sometimes significant distances from plant.The understanding flow behaviour (rheology) mixtures is therefore vital a reticulation design and operational point view.There are many methods determine rheology mixtures.Vane yield stress,...
A gold mine in East Africa has decided to implement a new paste backfill system.To the overall project while ensuring that all design, environmental and government requirements are satisfied, undertake comprehensive test work campaign understand their tailings.The program focused on following:1.Transport of tailings Tailings Storage Facility (TSF) 2.Tailings used for material.For design transportation system TSF, basic material slurry properties which were as inputs various other...