Leslie Bosseler

ORCID: 0000-0002-4351-5317
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Research Areas
  • Veterinary Oncology Research
  • Microbial infections and disease research
  • Turtle Biology and Conservation
  • Animal Virus Infections Studies
  • Rabies epidemiology and control
  • Congenital Anomalies and Fetal Surgery
  • Virus-based gene therapy research
  • Hepatitis B Virus Studies
  • Veterinary Medicine and Surgery
  • Metabolism and Genetic Disorders
  • Plant Virus Research Studies
  • Sarcoma Diagnosis and Treatment
  • Fetal and Pediatric Neurological Disorders
  • Renal and related cancers
  • Genetic Neurodegenerative Diseases
  • Vector-Borne Animal Diseases
  • Immunotherapy and Immune Responses
  • Animal Nutrition and Physiology
  • Cardiovascular Conditions and Treatments
  • Glioma Diagnosis and Treatment
  • Vascular Tumors and Angiosarcomas
  • Genetic and Kidney Cyst Diseases
  • Viral Infections and Outbreaks Research
  • Hepatitis C virus research
  • Veterinary Equine Medical Research

Janssen (Belgium)
2019-2023

Ghent University
2012-2020

Ghent University Hospital
2013-2020

Poultry Research Institute
2015

Callithrix jacchus (common marmoset) is regularly used in biomedical research, including for studies involving the skeleton. To support these studies, skeletons of healthy animals that had been euthanized reasons not interfering with skeletal anatomy were prepared. The marmoset dental formula 2I-1C-3P-2M each oral quadrant atypical New World monkeys which commonly possess a third molar. Seven cervical, 12–13 thoracic, 7–6 lumbar, 2–3 sacral and 26–29 caudal vertebrae are present,...

10.1258/la.2012.011167 article EN Laboratory Animals 2012-04-01

Epiploic foramen entrapment (EFE) is, based on the number of reports in literature, a relatively important life-threatening cause colic horses that could be prevented by closing epiploic (EF) at risk developing EFE.To describe laparoscopic epiploicum mesh closure (FEMC) technique and its outcome.Descriptive experimental study.The EF 6 was closed with FEMC technique. A diabolo-shaped constructed introduced into omental vestibule through under visualisation standing sedated horse. Clinical...

10.1111/evj.12427 article EN Equine Veterinary Journal 2015-02-13

Abstract Skin ulcerations rank amongst the most prevalent lesions affecting wild common dab ( Limanda limanda ) with an increase in prevalence of up to 3.5% Belgian part North Sea. A complex aetiology these is suspected, and many questions remain on exact factors contributing lesions. To construct aetiological spectrum skin flatfish, a one‐day monitoring campaign was undertaken Fifteen fish presented one or more pigmented and/or non‐pigmented side. Pathological features revealed various...

10.1111/jfd.12729 article EN Journal of Fish Diseases 2017-11-17

Fowl adenovirus infections are widely prevalent in poultry. Many of the viruses can infect chickens without resulting overt disease. Nevertheless, some fowl adenoviruses cause important disease complexes such as inclusion body hepatitis, hydropericardium syndrome, necrotic pancreatitis, and gizzard erosion. Adenoviral erosions have been regularly reported from Japan, but detailed reports Europe scarce available only Italy, Poland, Hungary, Germany. This case report describes two concurrent...

10.1637/11826-030918-case.1 article EN Avian Diseases 2018-09-01

Neoplastic disorders are frequently encountered in the practice of reptile medicine. Herein we report clinical behavior, antemortem diagnosis, and histopathologic characteristics a recurrent intraoral keratinizing basal cell carcinoma (BCC) metastatic BCC carapace 2 Hermann’s tortoises ( Testudo hermanni). Although squamous carcinomas (SCCs) show similar predilection sites gross pathologic features, BCCs described our were characterized by remarkably fast highly infiltrative growth...

10.1177/1040638716668560 article EN Journal of Veterinary Diagnostic Investigation 2016-09-30

Goose hemorrhagic polyomavirus (GHPV) is the causative agent of nephritis enteritis geese (HNEG), one major diseases domestic in Europe. This case report describes a persistent outbreak GHPV infection on Belgian goose farm. Clinical symptoms, necropsy lesions, and histopathologic lesions observed were compatible with previous reports HNEG outbreaks. PCR analysis confirmed diagnosis GHPV. To our knowledge, this first an evidence that not only present countries known for extensive waterfowl...

10.1637/11604-020317-case.1 article EN Avian Diseases 2017-12-01

A 5-month-old female captive Malayan tapir (Tapirus indicus) died suddenly without preceding symptoms. Gross necropsy revealed numerous white circular and linear foci in the myocard. Differential diagnosis all turned out negative, except for encephalomyocarditis virus. Histopathology mineralisation of myocardial cells interstitial infiltration lymphocytes, plasma less neutrophils. Encephalomyocarditis virus was detected by PCR. Although occurs many mammals, this is first published...

10.4314/ovj.v7i2.4 article EN cc-by-nc Open Veterinary Journal 2017-05-18

Phenobarbitone (phenobarbital) is an aromatic antiepileptic drug of the barbiturate family that known to occasionally cause adverse reactions in several animal species at both toxic and therapeu...

10.1080/00480169.2016.1260501 article EN New Zealand Veterinary Journal 2016-11-17

Een vierentwintig jaar oude merrie die zeven geleden onderzocht werd voor een mitralisklepregurgitatie en milde, linkszijdige cardiomegalie, aangeboden tachycardie, uitgesproken zweten spiertremor. Het bloedonderzoek toonde verhoogde hematocriet, metabole acidose, hypocalcemie, hyperglycemie cardiaal troponine I-concentratie aan. Elektrocardiografie talrijke ventriculaire premature contracties monomorfe tachycardie gevolgd door polymorfe met R-op-T fenomeen. Ondanks onmiddellijke behandeling...

10.21825/vdt.v86i4.16185 article NL cc-by Vlaams Diergeneeskundig Tijdschrift 2017-08-28

Suppression of HBV DNA, inhibition surface (HBsAg) production and therapeutic vaccination to reverse HBV-specific T-cell exhaustion in chronic patients are likely required achieve a functional cure. In the AAV-HBV mouse model, can be effective clearing when HBsAg levels low. Using single-cell approach, we investigated liver immune environment with different sustained loss through treatment GalNAc-HBV-siRNA followed by vaccination.AAV-HBV-transduced C57BL/6 mice were treated lower then...

10.3390/vaccines11121825 article EN cc-by Vaccines 2023-12-06

To date, reference values for 25-OH-vitamin D, parathyroid hormone (PTH), and calcium in serum of common marmosets (Callithrix jacchus) based on a large sample size are not available.Serum these parameters were determined correlated with sex, age, season sampling, time long bone epiphyseal closure captive-housed marmosets.The 90% range D is 47.40-370.4 nmol/L, PTH 2.10-30.51 pmol/L, 2.08-2.63 mmol/L. Lower levels vitamin measured fall compared the other seasons. Levels higher males than...

10.1111/jmp.12334 article EN Journal of Medical Primatology 2018-02-15

A 2.7-year-old male captive Asiatic lion (Panthera leo persica) died unexpectedly without preceding symptoms. Gross necropsy revealed liver and lung tumours, which proved to be haemangiosarcomas by histopathology. Some of the tumours were ruptured, leading massive intra-abdominal haemorrhage death. Haemangiosarcomas are rare in domestic exotic felids, occurring skin, thoracic-abdominal cavity bones. Although these mainly appear older cats, they sometimes observed younger animals, as present...

10.5455/ovj.2015.v5.i1.p52 article EN cc-by-nc Open Veterinary Journal 2015-01-01

Summary Multiple congenital ocular anomalies syndrome consists of several abnormalities mainly localised to the anterior segment eye. This condition, comprising iridal or ciliary cysts with without hypoplasia, an excessively protruding cornea (‘cornea globosa’), miotic pupils, retinal dysplasia, cataract, and other lesions, has been reported in breeds is strongly related silver coat colour, as a result dominant mutant allele at PMEL17 locus. report describes macroscopic, ultrasonographic,...

10.1111/eve.12293 article EN Equine Veterinary Education 2015-01-14

Via echografisch onderzoek werd de aanwezigheid van drie intracoelomale, ovoïde massa’s en een nodulair aspect lever aangetoond bij jaar oude, mannelijke baardagame (Pogona vitticeps) met anorexie. Het histologisch operatief verwijderde leverbiopt onthulden neoplastische cellen neuro-endocriene oorsprong. gastroscopisch ulceratief letsel in maag aangetoond. Op basis deze bevindingen er vermoedelijke diagnose neuro-endocrien carcinoom uitgebreide metastasen gesteld. Deze bevestigd door...

10.21825/vdt.v83i6.16627 article NL cc-by Vlaams Diergeneeskundig Tijdschrift 2014-12-30

Abstract Background & Aims Suppression of HBV DNA, inhibition HBsAg production and therapeutic vaccination to reverse HBV-specific T-cell exhaustion in chronic patients are likely required achieve functional cure. In the AAV-HBV mouse model, can be effective clearing when hepatitis B surface (HBsAg) levels low. The factor(s) for mounting an immune control infection unclear. Using a single-cell approach, we investigated liver environment context different as well upon sustained loss...

10.1101/2023.09.04.556204 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2023-09-06
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