A5057783048- Veterinary Medicine and Surgery
- Cardiovascular Conditions and Treatments
- Pediatric Urology and Nephrology Studies
- Veterinary Pharmacology and Anesthesia
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Veterinary Oncology Research
- Urological Disorders and Treatments
- Liver Disease and Transplantation
- Streptococcal Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Renal function and acid-base balance
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Gastroesophageal reflux and treatments
- Chronic Kidney Disease and Diabetes
- Veterinary Orthopedics and Neurology
- Radiopharmaceutical Chemistry and Applications
- Esophageal Cancer Research and Treatment
- Human-Animal Interaction Studies
- Ion Transport and Channel Regulation
- Congenital Anomalies and Fetal Surgery
- Electrolyte and hormonal disorders
- Hemodynamic Monitoring and Therapy
- Thallium and Germanium Studies
Ghent University
2018-2025
University College Ghent
2023
Ludwig-Maximilians-Universität München
2015
Hôpital Nord
1988
Chronic Kidney Disease (CKD) is one of the most common conditions affecting felines, yet metabolic alterations underlying its pathophysiology remain poorly understood, hindering progress in identifying biomarkers and therapeutic targets. This study aimed to provide a comprehensive view changes feline CKD across conserved biochemical pathways evaluate their progression throughout disease continuum. Using multi-biomatrix high-throughput metabolomics approach, serum urine samples from...
No prospective studies including large numbers of dogs with acute haemorrhagic diarrhoea syndrome (AHDS) are published so far. The aim this case–control study was to describe signalment, history, clinical signs, laboratory values and course disease in AHDS. Dogs (108) idiopathic (<3 days) were prospectively enrolled. Clinical assessment performed by calculation the ‘AHDS index’ (0–18). hospital population 21 healthy served as control groups. AHDS had a significantly lower body weight...
Glomerular filtration rate (GFR) is the gold standard in assessing renal function but impractical. Serum creatinine (sCr) has limited sensitivity identifying early chronic kidney disease (CKD), whereas symmetric dimethylarginine (SDMA) been commercialized as more accurate biomarker. Studies comparing SDMA and sCr with GFR cats are limited.To further investigate diagnostic performance of nonazotemic azotemic cats.Forty-nine client-owned cats: 17 CKD, 15 diabetes mellitus (DM), healthy...
Abstract Background Although regular health screening is recommended, long‐term follow‐up data in healthy aged cats are lacking. Objectives Determine the most common conditions a large group of apparently older and which diseases manifested within 2 years confirmed to be based on extensive screening. Animals Client‐owned cats. Methods Prospective study. Thorough history, physical examination, blood tests, urinalysis were performed 259 mature adult (7‐10 years) senior (>10 Semi‐annual...
Objectives The aim of this study was to document survival, complications and risk factors for the development mortality prior discharge after placement a subcutaneous ureteral bypass (SUB) device in cats. Methods medical records cats with SUB between January 2016 August 2019 were retrospectively analysed. (overall, intraoperative, perioperative, short- long-term complications) statistically assessed univariate binary logistic regression. All variables P value ⩽0.10 analysis multivariate...
Annual health screening is recommended in elderly cats to allow the early detection of conditions such as chronic kidney disease (CKD) and hyperthyroidism. Nevertheless, age-specific reference intervals (RIs) for renal thyroid parameters this population are lacking. The aim study was determine RIs selected serum urine biomarkers related CKD hyperthyroidism, namely creatinine (sCr), symmetric dimethylarginine (SDMA), phosphate (P), total calcium (tCa), thyroxine (TT4), urinary...
Although gut-derived uremic toxins are increased in azotemic chronic kidney disease (CKD) cats and implicated progression, it remains unclear if augmented formation or retention of these is associated with the development renal azotemia.
Abstract Background Urinary protein:creatinine ratio (UPC) results affect the diagnosis, prognosis, and therapy of chronic kidney disease in cats. Objectives To investigate interlaboratory intralaboratory variability effect storage on UPC International Renal Interest Society (IRIS) proteinuria substaging Animals Healthy diseased client‐owned Methods Prospective study. Urine 60 cats was randomly sent to 4 (of 9) participating laboratories (to assess variability) per cat, 2 each received...
Urinalysis is necessary for the diagnostic evaluation of chronic kidney disease in cats. Performing cystocentesis not always feasible, but data comparing urine obtained by clinic with voided samples collected at home are lacking cats.To compare urinary protein:creatinine ratio (UPC) and specific gravity (USG) to detect clinically relevant changes proteinuria substage or concentration between in-clinic cats.Ninety-two healthy diseased client-owned cats.Prospective study. Owners within 1 15...
Abstract Background Stability of serum symmetric dimethylarginine (sSDMA) during short‐ and long‐term storage has not been assessed for the immunoassay Point‐of‐Care IDEXX Catalyst DX (POC) analyzer Enzyme Multiplied Immunoassay Technique commercial laboratory (CL). Also, agreement between both analyzers is questioned. Objectives To determine (a) effect time temperature on sSDMA measured by POC CL; (b) (c) imprecision POC. Animals Serum cats (n = 17) dogs 18) with a range SDMA concentrations...
Laboratory results are influenced by presence and severity of disease, as well preanalytical factors, analytical variation, biological variation. Biological variation data for urinary protein: creatinine ratio (UPC) urine specific gravity (USG) in cats lacking.Determine the UPC USG cats.Eighty healthy client-owned cats.Prospective study. Urine was collected on days 0, 14, 56 from all 80 to investigate persistence borderline or overt proteinuria suboptimal concentration. In 15 these cats,...
Antimicrobial prophylaxis aims at decreasing the risk of surgical site infections (SSI) by administration antimicrobial drugs prior to surgery in animals risk. Multiple factors for development SSIs have been determined companion animals, and based on these factors, a flow diagram is proposed identify dogs cats that would benefit from prophylaxis. Furthermore, most identified bacteria healthy are listed per organ system with their recommended prophylactic drug(s). Besides optimal drug type,...
Abstract Background Liver‐type fatty acid‐binding protein (L‐FABP) and neutrophil gelatinase‐associated lipocalin (NGAL) are candidate biomarkers for the detection of early chronic kidney disease (CKD) in cats. Objective To evaluate urinary serum L‐FABP NGAL concentrations CKD cats hyperthyroid before after radioiodine ( 131 I) treatment. Animals Nine cats, 45 healthy at 3 time points including (T0, n = 49), 1 month (T1, 11 to 29 months (T2, 26) I Methods Cross‐sectional longitudinal study....
Abstract Background Urinary liver‐type fatty acid‐binding protein (uL‐FABP) is a promising biomarker to detect early chronic kidney disease (CKD) in cats. Few healthy cats show increased uL‐FABP for unknown reasons. Objectives The objective of this study was evaluate large elderly cat population comparing with and without International Renal Interest Society (IRIS) stage 1 CKD borderline proteinuria. Methods This cross‐sectional study. One hundred ninety‐six clinically client‐owned ≥7 years...
Borderline proteinuria is associated with decreased survival in cats azotemic chronic kidney disease (CKD).
Abstract Thallium was commonly used as a rodenticide in the past. It acts cellular poison and interferes with functioning of various enzymes. This report describes fatal case thallium intoxication dog gastrointestinal neurological signs well dermatological lesions. Cutaneous histopathology serum spectrometry confirmed toxicosis.
This case report describes Caroli syndrome in a young dog, which presented with fever, icterus, acute vomiting, weight loss, hyporexia and lethargy. Two days after hospital admission, the development of severe ascites prompted use abdominal CT, revealed presence thickened gall bladder wall dilation intrahepatic common bile ducts, duct sacculation, acquired extrahepatic portosystemic shunts. Exploratory coeliotomy mucocoele tortuous ducts. The owners opted not to follow further treatment...