A5031866509- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Reconstructive Surgery and Microvascular Techniques
- Mesenchymal stem cell research
- Coronary Interventions and Diagnostics
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Cardiomyopathy and Myosin Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- High Altitude and Hypoxia
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Cardiac and Coronary Surgery Techniques
- Nicotinic Acetylcholine Receptors Study
- Anesthesia and Neurotoxicity Research
- Pluripotent Stem Cells Research
- Helicobacter pylori-related gastroenterology studies
- Peripheral Artery Disease Management
- Orthopaedic implants and arthroplasty
- Tribology and Wear Analysis
- Neuroscience and Neuropharmacology Research
- Peptidase Inhibition and Analysis
- Vagus Nerve Stimulation Research
Washington University in St. Louis
2021-2025
Air Force General Hospital PLA
2017-2025
Qilu Hospital of Shandong University
2012-2025
First Affiliated Hospital of Zhengzhou University
2020-2024
New Hope Liuhe (China)
2024
Xingtai People's Hospital
2024
China University of Mining and Technology
2022-2024
Air Force Medical University
2011-2024
Capital Medical University
2019-2024
Hebei Medical University
2013-2024
Soft tissue losses from tumor removal, trauma, aging, and congenital malformation affect millions of people each year. Existing options for soft restoration have several drawbacks: Surgical such as the use autologous flaps lead to donor site defects, prosthetic implants are prone foreign body response leading fibrosis, fat grafting dermal fillers limited small-volume defects only provide transient volume restoration. In addition, large-volume other tissue-engineering attempts hampered by...
Due to their intrinsic injectable and self-healing characteristics, dynamic hydrogels, based on covalent bonds, have gained a great attention. In this study, novel hydrogel the boronic ester bond is facilely developed using phenylboronic acid-modified hyaluronic acid (HA-PBA) plant-derived polyphenol-tannic (TA). The gelated quickly under mild conditions had favorable viscoelastic properties with good shear-thinning capabilities. Moreover, simultaneous utilization of TA as reductant for...
T cell therapies require the removal and culture of cells ex vivo to expand several thousand-fold. However, these often lose phenotype cytotoxic functionality for mediating effective therapeutic responses. The extracellular matrix (ECM) has been used preserve augment phenotype; however, it not applied cellular immunotherapies. Here, a hyaluronic acid (HA)-based hydrogel is engineered present two stimulatory signals required T-cell activation-termed an artificial stimulating (aTM). It found...
The lack of blood–brain barrier (BBB) penetrating ability has hindered the delivery many therapeutic agents for tauopathy treatment. In this study, we report synthesis a circular bifunctional aptamer to enhance in vivo BBB penetration better therapy. consists one reported transferrin receptor (TfR) facilitate TfR-aptamer recognition-induced transcytosis across endothelial cells, and Tau protein that recently selected inhibit phosphorylation other tauopathy-related pathological events brain....
Nicorandil exerts myocardial protection through its antihypoxia and antioxidant effects. Here, we investigated whether it plays an anti-apoptotic role in diabetic cardiomyopathy. Sprague-Dawley rats were fed with high-fat diet; then single intraperitoneal injection of streptozotocin was performed. Rats fasting blood glucose (FBG) higher than 11.1 mmol/L selected as models. Eight weeks after the models built, treated nicorandil (7.5 mg/kg day 15 respectively) for 4 weeks. H9c2 cardiomyocytes...
Abstract Objective Chinese Herb QingBai decoction (QBD) has been approved affective in the treatment of IBD patients clinic. However, underlying mechanism remains unknown. We aim to investigate effect QBD on mouse model ulcerative colitis and its possible mechanism. Methods C57/bL mice were given 5% DSS induce divided as mesalazine group. Weight, faeces mental status recorded each day histopathological changes (goblet cells etc) colon observed after sacrificed. Fluorescein...
ABSTRACT Background Penicillin allergy significantly restricts therapeutic options for Helicobacter pylori eradication. This multicenter randomized controlled study was designed to evaluate the efficacy and safety of a novel cefuroxime–tetracycline‐containing bismuth quadruple therapy (Cef‐Tet BQT) as first‐line treatment in this population. Materials Methods Penicillin‐allergic treatment‐naïve patients with confirmed H. infection ( N = 248) were two 14‐day regimens: one received Cef‐Tet BQT...
Abstract Neuroinflammation is critically involved in the repair of spinal cord injury (SCI), and macrophages associated with inflammation propel degeneration or recovery pathological process. Currently, efforts have been focused on obtaining efficient therapeutic anti‐inflammatory drugs to treat SCI. However, these are still unable penetrate blood barrier lack ability target lesion areas, resulting unsatisfactory clinical efficacy. Herein, a polymer‐based nanodrug delivery system constructed...
The only clinically approved drug that reduces doxorubicin cardiotoxicity is dexrazoxane, but its application limited due to the risk of secondary malignancies. So, exploring alternative effective molecules attenuate crucial. Colchicine a safe and well-tolerated helps reduce production reactive oxygen species. High doses colchicine have been reported block fusion autophagosomes lysosomes in cancer cells. However, impact on autophagy activity within cardiomyocytes remains inadequately...
High altitude is characterized by low oxygen pressure, resulting in multiple adaptive responses. Tibetans who have lived the plateau for thousands of years developed unique phenotypes, such as downregulation HIF pathway through EPAS1 and EGLN1 gene mutation. However, changes hemoglobin-oxygen affinity under hypoxia environment remain elusive.A blood cell analyzer a were used to conduct routine tests measure P50 Han population that rapidly entered (for 3-7 days), plateau-acclimatized...
It is well known that sleep disorders are harmful to people's health and performance, growing evidence suggests deprivation (SD) can trigger neuroinflammation in the brain. The nucleotide-binding domain leucine-rich repeat protein-3 (NLRP3) inflammasome reported be relevant induced by SD, but regulatory signaling governs NLRP3 SD still unknown. Meanwhile, whether action of antidepressants astrocytes could affect also remains obscure. In this study, we were first discover antidepressant...
Abstract Muscle LIM protein (MLP, CSRP3 ) is a key regulator of striated muscle function, and its mutations can lead to both hypertrophic cardiomyopathy (HCM) dilated (DCM) in patients. However, due lack human models, mechanisms underlining the pathogenesis MLP defects remain unclear. In this study, we generated knockout MLP/CSRP3 embryonic stem cell (hESC) H9 line using CRISPR/Cas9 mediated gene disruption. disruption had no impact on cardiac differentiation cells led confirmed deficiency...
Abstract Minimally invasive therapies avoiding surgical complexities evoke great interest in developing injectable biomedical devices. Herein, a versatile approach is reported for engineering and biomimetic nanofiber microspheres (NMs) with tunable sizes, predesigned structures, desired compositions via gas bubble–mediated coaxial electrospraying. The sizes structures of NMs are controlled by adjusting processing parameters including air flow rate, applied voltage, distance, spinneret...
The ability to transform two-dimensional (2D) structures into three-dimensional (3D) leads a variety of applications in fields such as soft electronics, robotics, and other biomedical-related fields. Previous reports have focused on using electrospun nanofibers due their mimic the extracellular matrix. These studies often lead poor results dense small sizes 2D nanofiber membranes. Using unique method combining innovative gas-foaming molding technologies, we report rapid transformation...
Following traumatic or ischemic brain injury, rapid cell death and extracellular matrix degradation lead to the formation of a cavity at lesion site, which is responsible for prolonged neurological deficits permanent disability. Transplantation neural stem/progenitor cells (NSCs) represents promising strategy reconstructing promoting tissue regeneration. In particular, promotion neuronal migration, organization, integration transplanted NSCs critical success stem cell-based therapy. This...
ABSTRACT Background Potassium‐competitive acid blockers have demonstrated enormous potential in the eradication treatment of Helicobacter pylori infection, with tegoprazan being one representatives. The available data on safety and efficacy dual therapy are limited. Materials Methods multicenter, noninferiority, randomized‐controlled trial was conducted from May 2023 to March 2024. Treatment‐naive subjects were randomly assigned (1:1) enter either tegoprazan–amoxicillin (TA) group...
AIM:To evaluate the undifferentiated embryonal sarcoma of liver (UESL) in adults order to improve its diagnosis and treatment.METHODS: Four primary one recurrent cases UESL were clinicopathologically evaluated immunohistochemically investigated with a panel antibodies using EnVision+ system.Relevant literature about was reviewed. RESULTS:Three males female enrolled this study.Their chief complaints abdominal pain, weight loss, or fever.Laboratory tests, imaging pathological features similar...