A5100461737- Silicone and Siloxane Chemistry
- Surface Modification and Superhydrophobicity
- Electrospun Nanofibers in Biomedical Applications
- Advanced Polymer Synthesis and Characterization
- Advanced Sensor and Energy Harvesting Materials
- Neurological Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Synthesis and properties of polymers
- 3D Printing in Biomedical Research
- Osteoarthritis Treatment and Mechanisms
- Hydrogels: synthesis, properties, applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular Mechanics and Interactions
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Cell Image Analysis Techniques
- Botulinum Toxin and Related Neurological Disorders
- Neurological Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Preterm Birth and Chorioamnionitis
- Brain Tumor Detection and Classification
University of Nebraska Medical Center
2021-2025
Maternal and Child Health Hospital of Sichuan Province
2022-2025
Jilin University
2012-2025
First Affiliated Hospital of Xinjiang Medical University
2023-2025
Xinjiang Medical University
2023-2025
Center for Life Sciences
2023-2024
Tsinghua University
2023-2024
Qufu Normal University
2024
Tianjin University
2008-2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Postoperative abdominal adhesions are a common problem after surgery and can produce serious complications. Current antiadhesive strategies focus mostly on physical barriers unsatisfactory inefficient. In this study, we designed synthesized advanced injectable cream-like hydrogels with multiple functionalities, including rapid gelation, self-healing, antioxidation, anti-inflammation, anti-cell adhesion. The multifunctional were facilely formed by the conjugation reaction of...
Holistic understanding of physio-pathological processes requires noninvasive 3D imaging in deep tissue across multiple spatial and temporal scales to link diverse transient subcellular behaviors with long-term physiogenesis. Despite broad applications two-photon microscopy (TPM), there remains an inevitable tradeoff among spatiotemporal resolution, volumes, durations due the point-scanning scheme, accumulated phototoxicity, optical aberrations. Here, we harnessed concept synthetic aperture...
The lack of both digital light processing (DLP) compatible and biocompatible photopolymers, along with inappropriate material properties required for wearable sensor applications, substantially hinders the employment DLP 3D printing in fabrication multifunctional hydrogels. Herein, we discovered implemented a photoreactive poloxamer derivative, Pluronic F-127 diacrylate, which overcomes these limitations is optimized to achieve printed micelle-based hydrogels high structural complexity,...
Recent progress on the preparation and surface characteristics of polymeric anti-icing coatings from low energy or liquid-infused slippery surfaces is reviewed illustrated.
Abstract In the past decade, cartilage tissue engineering has arisen as a promising therapeutic option for degenerative joint diseases, such osteoarthritis, in hope of restoring structure and physiological functions. Hydrogels are biomaterials developing engineered scaffolds regeneration. However, hydrogel-delivered mesenchymal stem cells or chondrocytes could be exposed to elevated levels reactive oxygen species (ROS) inflammatory microenvironment after being implanted into injured joints,...
Bioinks for 3D bioprinting of tumor models should not only meet printability requirements but also accurately maintain and support phenotypes surrounding cells to recapitulate key hallmarks. Collagen is a major extracellular matrix protein solid tumors, low viscosity collagen solution has made bioprinted cancer challenging. This work produces embedded, breast organoid using low-concentration I based bioinks. The biocompatible physically crosslinked silk fibroin hydrogel used generate the...
Purpose.: Müller glia respond to retinal injury by a reactive gliosis, but only rarely do mammalian glial cells re-enter the cell cycle and generate new neurons. In nonmammalian retina, however, act as stem/progenitor cells. Here, we tested function of Wnt signaling in postinjury focusing on its ability influence dedifferentiation, proliferation, neurogenesis. Methods.: A 532 nm frequency doubled neodymium-doped yttrium aluminum garnet (Nd:YAG) laser was used create light burns retina...
Ice accretion poses a severe impact on diverse aspects of human life. Although great efforts have been dedicated to prevent or alleviate ice adhesion the surface substrates by developing various icephobic coatings, it is still needed improve integrated performance. Herein, we present novel strategy prepare poly(dimethylsiloxane) (PDMS) slippage coatings combining soft architecture-driven branched PDMS with partial short PDMS-functionalized polyhedral oligomeric silsesquioxane (POSS) as...
Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden. Exosomes, especially those derived from mesenchymal stem cells (MSCs), are promising as potential cell-free therapeutics gene therapy vehicles for promoting neural regeneration. In this study, we reported differentiation of human adipose MSCs (hADMSCs) towards Schwann cell (SC) phenotype (hADMSC-SCs) then isolated exosomes hADMSCs with without (i.e.,...
Following traumatic or ischemic brain injury, rapid cell death and extracellular matrix degradation lead to the formation of a cavity at lesion site, which is responsible for prolonged neurological deficits permanent disability. Transplantation neural stem/progenitor cells (NSCs) represents promising strategy reconstructing promoting tissue regeneration. In particular, promotion neuronal migration, organization, integration transplanted NSCs critical success stem cell-based therapy. This...
Phenotype transformation of vascular smooth muscle cells (VSMCs) is known to be modulated by mechanical strain. The present study was designed investigate how different frequencies strain affected VSMC phenotype. VSMCs were subjected the strains 10% elongation at 0, 0.5, 1 and 2 Hz for 24 h using a Flexercell unit. phenotype assessed cell morphology, measurement two-dimensional area, Western blotting protein RT-PCR mRNA expression differentiation markers. Possible kinases involved evaluated...
Resistin is an adipocytokine associated with inflammation and insulin resistance. Recent studies have shown that resistin plays important role in the pathogenesis progression osteoarthritis (OA) patients. The current study was aimed at investigating relationship between serum synovial fluid (SF) disease severity patients knee osteoarthritis.Seventy-four diagnosed OA 79 healthy controls receiving regular body check our hospital were recruited study. Noyes score method used to assess articular...