A5024981230- Exercise and Physiological Responses
- RNA and protein synthesis mechanisms
- Sperm and Testicular Function
- RNA Research and Splicing
- Vascular Tumors and Angiosarcomas
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Petroleum Processing and Analysis
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Biochemical and Molecular Research
- Microbial bioremediation and biosurfactants
- Protein Kinase Regulation and GTPase Signaling
- Electrospun Nanofibers in Biomedical Applications
- Ubiquitin and proteasome pathways
- Bacterial Genetics and Biotechnology
- Angiogenesis and VEGF in Cancer
- Acute Myeloid Leukemia Research
- Surgical Sutures and Adhesives
- Physical Activity and Health
- Hernia repair and management
- Coenzyme Q10 studies and effects
- Endoplasmic Reticulum Stress and Disease
Northeastern University
2023-2025
Eastern University
2023-2024
University of Nebraska Medical Center
2021-2023
Glocal University
2023
National Centre for Biological Sciences
2016-2021
Indian Institute of Technology Kanpur
2008-2013
Postoperative abdominal adhesions are a common problem after surgery and can produce serious complications. Current antiadhesive strategies focus mostly on physical barriers unsatisfactory inefficient. In this study, we designed synthesized advanced injectable cream-like hydrogels with multiple functionalities, including rapid gelation, self-healing, antioxidation, anti-inflammation, anti-cell adhesion. The multifunctional were facilely formed by the conjugation reaction of...
The present study describes the structural characterization and biotechnological application of a dirhamnolipid biosurfactant produced by<italic>Pseudomonas aeruginosa</italic>strain NBTU-01 isolated from petroleum oil-contaminated soil sample.
Decellularized nerve hydrogels (dNHs) containing bioactive molecules are promising biomaterials for peripheral injury (PNI) treatment and have been extensively applied in clinical preclinical practice. However, most previous research projects studied their influences on nerve-related cellular behaviors two dimensions (2D) without taking hydrogel biomechanics into consideration. The molecular mechanisms underlying the beneficial microenvironment provided by dNHs also remain unclear. In this...
Exercise training (ExT) improves skeletal muscle health via multiple adaptative pathways. Nrf2 is a principal antioxidant transcription factor responsible for maintaining intracellular redox homeostasis. In this study, we hypothesized that essential responses to ExT and thus beneficial muscle. Experiments were carried out on male wild type (WT) iMS-Nrf2flox/flox inducible muscle-specific (KO) mice, which randomly assigned serve as sedentary controls (Sed) or underwent 3 weeks of treadmill...
Abstract Tumor‐targeted, activatable photoimmunotherapy (taPIT) has shown promise in preclinical models to selectively eliminate drug‐resistant micrometastases that evade standard treatments. Moreover, taPIT the potential resensitize chemo‐resistant tumor cells chemotherapy, making it a complementary modality for treating recurrent high‐grade serous ovarian cancer (HGSOC). However, established implementation of relies on overexpression EGFR cells, which is not universally observed HGSOCs....
HflX is a GTP binding protein of unknown function. Based on the presence hflX gene in hflA operon, was believed to be involved lytic-lysogenic decision during phage infection Escherichia coli. We find that E. coli binds 16S and 23S rRNA - RNA components 30S 50S ribosomal subunits. Here, using purified subunits, we show specifically interacts with 50S. This finding line homology GTPases ribosome biogenesis. However, HflX-50S interaction not limited specific nucleotide-bound state protein, any...
GTPases are important regulatory proteins that hydrolyze GTP to GDP. A novel GTP-hydrolysis mechanism is employed by MnmE, YqeH and FeoB, where a potassium ion plays role analogous the Arginine finger of Ras-RasGAP system, accelerate otherwise slow hydrolysis rates. In these proteins, two conserved asparagines 'K-loop' present in switch-I, were suggested as attributes employing K(+)-mediated mechanism. Based on their conservation, similar was for TEES family GTPases. Recently, Dynamin, Fzo1...
A role for HflX in 50S-biogenesis was suggested based on its similarity to other GTPases involved this process. It possesses a G-domain, flanked by uncharacterized N- and C-terminal domains. Intriguingly, Escherichia coli shown hydrolyze both GTP adenosine triphosphate (ATP), it unclear whether G-domain alone would explain ATP hydrolysis too. Here, structural bioinformatics analysis, we suspected the possible existence of an additional nucleotide-binding domain (ND1) at N-terminus....
Mammalian skeletal muscle (SkM) tissue engages the Nrf2-Keap1-dependent antioxidant defense mechanism to respond adaptively stress. Redox homeostasis mediated by reversible modification of selective cysteines is prevalent mode regulation. The protein targets SkM redox regulation are largely unknown. We previously reported proteomic profiles soleus (Sol) and extensor digitorum longus (EDL) with Nrf2 or Keap1 gene deletion, using SkM-specific knockout models; iMS-Nrf2flox/flox;...
Abstract Colorectal cancer (CRC) is one of the most leading causes cancer-related death in world because cases are diagnosed advanced stages, when development resistance to chemotherapy more frequent. To face this situation, new therapeutic drugs desperately needed for patients with cancer, but making safe and efficacious remains expensive time consuming. Given high attrition rates, substantial costs slow pace drug discovery further development, repurposing 'old' increasingly becoming an...