A5100771038- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Mesenchymal stem cell research
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Urinary Bladder and Prostate Research
- Pancreatic function and diabetes
- Testicular diseases and treatments
- Metabolism, Diabetes, and Cancer
- Renal and related cancers
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Osteoarthritis Treatment and Mechanisms
- Adipose Tissue and Metabolism
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Advanced Glycation End Products research
- Paleopathology and ancient diseases
- Congenital heart defects research
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Multiple and Secondary Primary Cancers
- Polyomavirus and related diseases
The People's Hospital Tongling
2025
Ningxia Medical University
2019-2024
Chinese People's Liberation Army
2023
West China Hospital of Sichuan University
2013-2022
Sichuan University
2013-2022
Shanghai First People's Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2021
Gansu University of Traditional Chinese Medicine
2021
Qilu Hospital of Shandong University
2019-2021
State Key Laboratory of Biotherapy
2021
Abstract Diabetic cardiomyopathy (DCM) is one of the leading causes heart failure in patients with diabetes mellitus, limited effective treatments. The cardioprotective effects sodium‐glucose cotransporter 2(SGLT2) inhibitors have been supported by amounts clinical trials, which largely fills gap. However, underlying mechanism still needs to be further explored, especially terms its protection against cardiac fibrosis, a crucial pathophysiological process during development DCM. Besides,...
Nicorandil exerts myocardial protection through its antihypoxia and antioxidant effects. Here, we investigated whether it plays an anti-apoptotic role in diabetic cardiomyopathy. Sprague-Dawley rats were fed with high-fat diet; then single intraperitoneal injection of streptozotocin was performed. Rats fasting blood glucose (FBG) higher than 11.1 mmol/L selected as models. Eight weeks after the models built, treated nicorandil (7.5 mg/kg day 15 respectively) for 4 weeks. H9c2 cardiomyocytes...
The oxidative stresses are a major insult in pulmonary injury such as acute lung (ALI) and respiratory distress syndrome (ARDS), two clinical manifestations of failure with substantially high morbidity mortality. Mesenchymal stem cells (MSCs) hold promise treatments many human diseases, mainly owing to their capacities immunoregulation antioxidative activity. strong immunoregulatory role placental MSCs fetal origin (hfPMSCs) has been previously demonstrated; antioxidant activity, however,...
Abstract BACKGROUND: Sunitinib has replaced interferon (IFN) as a first‐line standard of care in the treatment metastatic renal cell carcinoma (RCC). This study aimed to determine overall survival and confirm effectiveness population that includes poor prognosis patients. METHODS: Data were collected on all patients identified by BC Cancer Registry with RCC who treated IFN or sunitinib. The group consisted received between January 2000 October 2005, sunitinib included from 2005 September...
Pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase 1 (PHLPP1) is a kind of serine/threonine phosphatase, whose dysregulation accompanied with numerous human diseases. However, its role in diabetic cardiomyopathy remains unclear. We explored the underlying function and mechanism PHLPP1 (DCM).In vivo, Type rats were induced by intraperitoneal injection 60 mg/kg streptozotocin (STZ). Lentivirus-mediated short hairpin RNA (shRNA) was used to knock down expression PHLPP1. In...
Abstract BACKGROUND Prostate cancer (PCa) risk‐associated single‐nucleotide polymorphisms (SNPs) are continuously being discovered. Their ability to identify men at high risk and the impact of increasing numbers SNPs on predictive performance not well understood. METHODS Absolute for PCa was estimated in a population‐based case–control study Sweden (2,899 cases 1,722 controls) using family history three sets sequentially discovered SNPs. predicting assessed by positive values (PPV)...
Gold nanoparticles (Au-NPs) hold significant promise in lung cancer treatment due to their unique physicochemical properties, enabling targeted drug delivery, enhanced therapeutic efficacy, and reduced systemic toxicity. This study is aimed produce the Au-NPs utilising Moringa oleifera evaluate effectiveness of cancer, with a specific focus on A549 cell lines. The synthesis was carried out by combining 10 mL an aqueous extract M. 190 1 mM HAuCl4 solution. synthesized were characterised using...
We present a case of Ewing’s sarcoma and primitive neuroectodermal tumour (PNET) the prostate. A 29-year-old male presented with difficult defecation anus distention; on magnetic resonance imaging scan pelvis, we found prostate tumour. transrectal ultrasound-guided needle biopsy confirmed diagnosis. The patient underwent cystoprostatectomy replacement ileocystoplasty was followed by multi-agent chemotherapy. PNET/ is extremely rare. prognosis very poor, so should pay enough attention to...
Background: Mesenchymal Stem Cells (MSCs) are pivotal in immunomodulation, hematopoiesis, and tissue repair. The interplay between MSCs the pathological microenvironment influences their proliferation differentiation. Transforming Growth Factor-Beta 1 (TGF- β1) serves as a key cytokine MSC microenvironment. This study aimed to scrutinize impact of TGF-β1 on human placenta-derived fetal origin (fPMSCs) elucidate its underlying mechanism. Methods: fPMSCs were isolated, surface markers...
The objective of this study was to analyze the effect expression WWOX and p53 on growth MG-63 osteosarcoma cells explore correlation between p53. p53-overexpressing cell lines were established by transfection named MW MP lines, respectively. Untransfected (blank control) used as control. Quantitative polymerase chain reaction (qPCR) western blot analysis detect wild-type mRNA protein, effects (wild-type) activity determined MTT assay flow cytometry. mutant protein in 65 cases detected...
Trastuzumab plus chemotherapy remains the standard first-line treatment strategy for HER2-positive gastric cancer (GC). resistance, on other hand, a significant issue. There are few effective anti-HER2 agents patients who develop resistance to trastuzumab.A 49-year-old female was diagnosed with stage IV GC liver and lung metastasis in July 2017. She underwent gastrostomy, immunohistochemistry (IHC) result of postoperative tissue demonstrated HER2 (3+). received trastuzumab (440 mg),...
To explore the role of a new urethral sheath in transurethral lithotripsy for bladder calculi.The 120 cases with stone (BS) models were divided into three groups. One was placed each case. A total 40 included group. Then, further control group 1, 2, and test 15, 10 cases, respectively. The sizes stones used 1.5, 2.0, 3.0 cm, In ureteroscope used. inserted via outer resectoscope. group, used.Mean BS removal times 86±15.5, 45.5±12.2, 11.5±5.5 minutes, respectively (P=0.001, n=40). For diameter...
A limited number of studies have investigated the significance cystatin C, creatinine, uric acid and urea in prostate cancer. The present study aimed to explore correlation between these molecules total prostate‑specific antigen (tPSA) levels using big data from patients different Chinese ethnicities. Patients undergoing physical examination at Medical Examination Center West China Hospital (Chengdu, China) January 2010 May 2019 were retrospectively included. χ<sup>2</sup> test or...
We present a case of Ewing’s sarcoma (ES) and primitive neuroectodermal tumor (PNET) prostate. A 29-year-old male presented with difficult defecation anus distention was found on magnetic resonance imaging (MRI) scan the pelvis to have prostate tumor. transrectal ultrasound guided needle biopsy confirmed diagnosis. The patient underwent cystoprostatectomy replacement ileocystoplasty followed by multiagent chemotherapy. PNET/EWS is an extremely rare neoplasm. And prognosis very poor, so we...
To explore the mechanism of p38MAPK signaling pathway in repairing articular cartilage defects with biological collagen membranes.Thirty-two healthy adult male rabbits were randomly divided into a control group (n = 8), model treatment 8) and positive drug 8). The was fed normally, models bilateral knee joint femoral established other three groups. not treated, membrane implanted group, glucosamine hydrochloride intragastrically administered group. Twelve weeks after operation, repair...
Mesenchymal stem cells (MSCs) are promising remedies for various inflammatory disease including pulmonary fibrosis (PF). However, the properties of MSCs in PF pathological microenvironment remain unclear. In this study, efficacy autophagy placental mesenchymal fetal origin (fPMSCs) either IL-1β treatment or BLM induced mice model was examined. The characteristic fPMSCs identified by morphological observation, flow cytometry and differentiation potential. vitro experiments, were stimulated...