A5024515107- Dialysis and Renal Disease Management
- HIV/AIDS drug development and treatment
- Renal Diseases and Glomerulopathies
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Kidney Disease and Diabetes
- Organ Donation and Transplantation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Palliative Care and End-of-Life Issues
- Renal Transplantation Outcomes and Treatments
- Global Maternal and Child Health
- Pregnancy and preeclampsia studies
- Diagnosis and treatment of tuberculosis
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Lupus Erythematosus Research
- Adolescent and Pediatric Healthcare
- COVID-19 and healthcare impacts
- Healthcare Systems and Reforms
- Acute Kidney Injury Research
- Nephrotoxicity and Medicinal Plants
- Hemoglobinopathies and Related Disorders
- Infectious Diseases and Tuberculosis
- Healthcare cost, quality, practices
University of Cape Town
2014-2025
Groote Schuur Hospital
2014-2024
Hypertension Institute
2023
Royal Prince Alfred Hospital
2000
HIV-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex and comorbid as well injury resulting from prolonged exposure to antiretroviral therapy or opportunistic infections. Clinical guidelines disease prevention treatment in largely extrapolated studies the general population, do not fully incorporate existing knowledge of unique HIV-related pathways genetic factors that...
Two hundred and twenty-one HIV-positive renal biopsies were analysed from Groote Schuur Hospital to determine outcomes prognostic indicators based on histology clinical features.The findings compared with patient demographics, parameters, mortality, CD4 count date of commencing combined anti-retroviral therapy (cART). Follow-up was between 1 3.5 years.We found a spectrum histologies in patients which HIV-associated nephropathy (HIVAN) the most common histology. cART reduced mortality those...
ABSTRACT Background Conservative kidney management (CKM) describes supportive care for people living with failure who choose not to receive or are unable access replacement therapy (KRT). This study captured the global availability of CKM services and funding. Methods Data came from International Society Nephrology Global Kidney Health survey conducted between June September 2022. Availability CKM, infrastructure, guidelines, medications training were evaluated. Results was available in some...
End Stage Kidney Disease (ESKD) is a public health problem with an enormous economic burden. In resource limited settings management of ESKD often rationed. Racial and socio-economic inequalities in selecting candidates have been previously documented South Africa. New guidelines for dialysis developed the Western Cape focused on prioritizing treatment. With this mind we aimed at exploring whether new would improve documented. A retrospective study patients presented to selection committee...
The cause of the human immunodeficiency virus (HIV) epidemic in South Africa (SA) was worsened by denial key political players that HIV causes acquired syndrome (AIDS). continues to have highest rate world-wide, which has had a huge impact on development both chronic kidney disease and acute injury. Fortunately, there is now an effective antiretroviral therapy (ART) roll-out program. SA also dealing with collision epidemics HIV, tuberculosis, non-communicable disease, particularly...
Sub-Saharan Africa remains challenged by the highest burden of human immunodeficiency virus (HIV), an epidemic tuberculosis (TB), and increasing number people with HIV (PWH) on antiretroviral therapy (ART), all which may result in kidney injury.This observational cohort study describes spectrum disease PWH South Africa, between 2005 2020. Kidney biopsies were analyzed 4 time periods as follows: early ART rollout (2005-2009), tenofovir disoproxil (TDF) introduction (2010-2012), TDF-based...
ABSTRACT South Africa continues to be burdened by human immunodeficiency virus (HIV) and tuberculosis (TB). In Cape Town, the epidemic of HIV‐TB co‐infection is as high 70%. Granulomatous interstitial nephritis (GIN) has increased in frequency on renal biopsy. This study aimed determine GIN prevalence causes HIV‐positive patients well outcomes, patient survival associated factors. observational cohort reviewed biopsies for from 2005 2012. Causes (medications, TB, fungal other), baseline...
Background South Africa (SA) currently performs the most peritoneal dialysis (PD) in Africa. Yet outcome data on PD programs continent are limited. With escalating need for renal replacement, remains a life-saving modality especially as hemodialysis is limited public sector. This study aims to evaluate and report outcomes of PD-First program performed resource-limited setting identify factors linked poor outcomes. Methods observational cohort was at Groote Schuur Hospital, analyzing all...
HIV-infected individuals are at increased risk of tissue inflammation and accelerated vascular aging ('inflamm-aging'). Abnormal diurnal blood pressure (BP) rhythms such as non-dipping may contribute to an cardiovascular cerebrovascular events in HIV infected individuals. However, little data exists on ambulatory (ABP) measures stiffness the black African population.This is a cross-sectional analysis otherwise well, outpatients ART for >5 years. Study assessments included: 24hr ABP...
Objectives: Human immunodeficiency virus (HIV) and antiretroviral therapy (ART) are associated with renal disease increased cardiovascular risk.The relationship between HIV ambulatory blood pressure (ABP) non-dipping status, a risk factor for events targetorgan damage, has never been assessed in South Africa.Study objectives were to establish the prevalence of chronic kidney disease, assess ABP profile asymptomatic HIV-positive clinic out-patients.Methods: This was prospective cohort...
Introduction Access to dialysis and transplantation in the developing world remains limited. Therefore, optimising renal allograft survival is essential. This study aimed evaluate clinical outcomes identify poor prognostic factors transplant programme at Groote Schuur Hospital [GSH], Cape Town. Method Data were collected on all patients who underwent a kidney GSH from 1st July 2010 30 June 2015. Analyses performed assess baseline characteristics, graft patient survival, as well predictors of...