A5071369844- Renal Diseases and Glomerulopathies
- HIV/AIDS drug development and treatment
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Muscle and Compartmental Disorders
- Dialysis and Renal Disease Management
- HIV Research and Treatment
- HIV-related health complications and treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- HIV/AIDS Research and Interventions
- Acute Kidney Injury Research
- Coordination Chemistry and Organometallics
- Genetic and Kidney Cyst Diseases
- Growth Hormone and Insulin-like Growth Factors
- Child and Adolescent Psychosocial and Emotional Development
- Long-Term Effects of COVID-19
- Face Recognition and Perception
- Blood Coagulation and Thrombosis Mechanisms
- Musculoskeletal pain and rehabilitation
- Renal and Vascular Pathologies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Treatment and Access
- Deception detection and forensic psychology
- Digestive system and related health
Albert Einstein College of Medicine
2017-2024
Carle Foundation Hospital
2024
Montefiore Health System
2021-2024
Montefiore Medical Center
2017-2023
Icahn School of Medicine at Mount Sinai
2007-2021
Lehigh Valley Health Network
2020
Yeshiva University
2020
UCLouvain Saint-Louis Brussels
1990-2018
Center for Translational Molecular Medicine
2016-2017
Saint Louis University
1990-2017
HIV-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex and comorbid as well injury resulting from prolonged exposure to antiretroviral therapy or opportunistic infections. Clinical guidelines disease prevention treatment in largely extrapolated studies the general population, do not fully incorporate existing knowledge of unique HIV-related pathways genetic factors that...
The efficacy of glucocorticoids in COVID-19 is unclear. This study was designed to determine whether systemic glucocorticoid treatment patients associated with reduced mortality or mechanical ventilation. observational included 1,806 hospitalized patients; 140 were treated within 48 hours admission. Early use not However, initial C-reactive protein (CRP) ≥20 mg/dL significantly risk ventilation (odds ratio, 0.23; 95% CI, 0.08- 0.70), while CRP <10 increased (OR, 2.64; 1.39-5.03). Whether...
Twenty-five cases of multilocular peritoneal inclusion cysts (MPIC) were investigated. All but four associated with a history previous abdominal or pelvic operation, evidence endometriosis inflammatory disease, combinations these findings. the lesions attached to organs, 44% also occupied upper cavity, and 16% involved retroperitoneum. In three free-floating present as well. The median diameter was 13 cm. cyst locules lined by one several layers flat cuboidal mesothelial cells that...
Localized thrombosis was produced in the left anterior descending (LAD) coronary artery of open chest dogs by constricting a segment so as to produce greater than 90% stenosis (reducing blood flow 40 +/- 10% baseline), and placing thrombus immediately proximal inducing endothelial cell injury instilling mixture thrombin. Intravenous infusion recombinant tissue-type plasminogen activator (rt-PA) at rate 15-30 micrograms/kg per min for 30 or 60 eight induced reperfusion within 23 7 (mean SD),...
The rise in the number of patients with HIV-associated nephropathy and HIV-infection end-stage renal disease (HIV+ ESRD) continues to be a substantial concern for ESRD program. In order assess impact highly active antiretroviral therapy (HAART) on progression AIDS development project prevalence HIV+ through 2020, mathematical model dynamics infection population was developed. Epidemiologic data among black individuals United States were obtained since 1991 from Centers Disease Control...
The site of recA cleavage the phage X and P22 repressors has been determined.Each repressor is cut once by enzyme, between residues 111 112, 94 95.recA occurs at identical alanyl-glycyl sequences in both repressors, separates repressor's NHz-terminal DNA-binding domain from its COOH-terminal oligomerization domain.A papain-generated proteolytic fragment consisting 93-236 also efficiently cleaved protein.Moreover, radioactive can be inhibited certain fragments which do not contain...
NF-κB is a central mediator of innate immunity and contributes to the pathogenesis several renal diseases. FAT10 TNF-α–inducible ubiquitin-like protein with putative role in immune response, but whether participates TNF-α–induced activation unknown. Here, using tubular epithelial cells (RTECs) derived from FAT10−/− FAT10+/+ mice, we observed that deficiency abrogated reduced induction NF-κB–regulated genes. Despite normal IkBα degradation polyubiquitination, impaired nuclear translocation...
Dysregulated apoptosis of renal tubular epithelial cells (RTEC) is an important component the pathogenesis several diseases, including HIV-associated nephropathy (HIVAN), most common cause chronic kidney failure in HIV-infected patients. In HIVAN, RTEC become infected by HIV-1 a focal distribution, and infection has been shown to induce vitro. microarray studies that used novel cell line from patient with it was found ubiquitin-like protein FAT10 one upregulated genes cells. Previously,...
Summary: HIV-associated nephropathy (HIVAN) is the most common cause of chronic renal failure in HIV-infected patients. Tubulointerstitial inflammation a prominent component histopathology HIVAN. The pathogenesis HIVAN result infection epithelial cells, but cellular response to this remains poorly defined. In these studies, we used oligonucleotide microarrays identify differentially expressed genes tubular cells from patient with at three time points after vesicular stomatitis...
A human alpha interferon, designated HuIFN-alpha A, produced in E. coli by direct expression of cloned cDNA [Goeddel et al., Nature 287, 411--416 (1980)] has been purified from bacterial extracts and characterized. The protein a molecular weight (19,400 SDS/PAGE) amino acid composition consistent with the DNA sequence. pI was determined to be 6.1. molecule specific activity 1.5 x 10(8) NIH reference units/mg protein. sequence first 35 acids is identical that expected nucleotide About 50%...
AKI has been reported in patients with COVID-19 pneumonia and it is associated higher mortality. The aim of our study to describe characteristics, outcomes, 60-day hospital mortality the intensive care unit (ICU).We conducted a retrospective which all adult confirmed who were admitted ICUs Montefiore Medical Center developing included. period ranged from March 10 April 11, 2020. follow-up data through June 2020 obtained.Of 300 adults pneumonia, 224 (75%) presented or developed subsequent...
The efficacy of a cognitive-behavioral intervention (stress inoculation training; SIT) for postsurgical anxiety, pain, and physical rehabilitation in injured athletes was tested. Sixty male who underwent arthroscopic surgery miniscus injury 1 knee were randomly assigned to either treatment (SIT therapy) or control (physical therapy only) conditions. Results showed that participants the group demonstrated significantly less pain anxiety during process, compared with controls. Additionally,...