A5050994439- Inflammatory Bowel Disease
- Appendicitis Diagnosis and Management
- Microscopic Colitis
- Hidradenitis Suppurativa and Treatments
- Colorectal and Anal Carcinomas
- Advanced MRI Techniques and Applications
- Diverticular Disease and Complications
- MRI in cancer diagnosis
- Diagnosis and treatment of tuberculosis
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Medical Imaging Techniques and Applications
- Renal cell carcinoma treatment
Brown University
2015-2025
Dartmouth–Hitchcock Medical Center
2024
Rhode Island Hospital
2013-2023
Rockefeller University
2019-2022
Albert Einstein College of Medicine
2019-2022
Lifespan
2010-2022
Centre Max Weber
2017-2022
Lenox Hill Hospital
2021
Institut universitaire du cancer de Toulouse Oncopole
2016-2021
Centre Hospitalier Universitaire de Toulouse
2017-2021
To retrospectively evaluate effectiveness, follow-up imaging features, and safety of microwave ablation in 50 patients with intraparenchymal pulmonary malignancies.This HIPAA-compliant study was approved by the institutional review board; informed consent waived. From November 10, 2003, to August 28, 2006, 82 masses (mean, 1.42 per patient) (28 men, 22 women; mean age, 70 years) were percutaneously treated 66 sessions. Each tumor ablated computed tomographic (CT) guidance. Follow-up contrast...
Exosomes are small vesicles secreted by different immune cells and which display anti‐tumoral properties. Stimulation of RBL‐2H3 with ionomycin triggered phospholipase D2 (PLD2) translocation from plasma membrane to intracellular compartments the release exosomes. Although exosomes carry two isoforms PLD, PLD2 was enriched specifically sorted on when overexpressed in cells. PLD activity present clearly increased following overexpression. correlated amount exosome released, as measured FACS....
The objective of our study was to determine the relationship between apparent diffusion coefficient (ADC) value on diffusion-weighted imaging (DWI) and Gleason score prostate cancer percentage tumor involvement core biopsy. We performed a retrospective 57 patients with biopsy-proven who underwent endorectal MRI DWI July 2007 March 2008. Regions interest (ROIs) were drawn ADC maps at sites visible DW images maps. A hierarchic mixed linear model used compare Eighty-one least-squares mean for...
Inflammatory abdominal aortic aneurysm (AAA) accounts for 5% to 10% of all cases AAA and differs from typical atherosclerotic in many important ways. Although both inflammatory most commonly affect the infrarenal portion aorta, patients with variant are younger usually symptomatic, chiefly back or pain. Unlike AAA, have an elevated erythrocyte sedimentation rate abnormalities other serum markers. Computed tomography magnetic resonance imaging sensitive demonstrating cuff soft tissue...
Rearrangements of the anaplastic lymphoma kinase (ALK) gene in non-small cell lung cancer (NSCLC) represent a novel molecular target small subset tumors. Although ALK rearrangements are usually assessed by immunohistochemistry (IHC) and fluorescence situ hybridization (FISH), approaches have recently emerged as relevant alternatives routine laboratories. Here, we evaluated use two different amplicon-based next-generation sequencing (NGS) methods (AmpliSeq Archer®FusionPlex®) to detect...
Dynamic MDCT for Localization of Occult Parathyroid Adenomas in 26 Patients With Primary HyperparathyroidismMichael D. Beland1, William W. Mayo-Smith1, David J. Grand1, Jason T. Machan2 and Jack M. Monchik3Audio Available | Share
We investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using Illumina TruSight Fusion panel. did not retrieve SLC44A1-PRKCA fusion gene specific for tumor, but an EWSR1-PATZ1 transcript. RT-PCR followed Sanger confirmed fusion. It matched canonic EWSR1 oncogene, juxtaposing entire N-terminal transcriptional activation domain and C-terminal DNA binding transcription factor gene, PATZ1. PATZ1 protein belongs to...
Background Hidradenitis suppurativa (HS) is an inflammatory skin disease with dysregulation of the interleukin (IL)-17 axis. Recently, we reported clinical benefit brodalumab, a human anti-IL-17 receptor A (IL-17RA) monoclonal antibody, in moderate-to-severe HS. Objectives To characterize molecular response to brodalumab HS and serum, identify biomarkers treatment response. Methods Ten participants, who received 210 mg /1·5 mL subcutaneously at weeks 0, 1, 2, 4 every 2 thereafter, were...
Mutation of the KRAS oncogene is present in 75% to 95% pancreatic cancer tissues. This study aimed evaluate whether endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), combined with analysis mutation, improves diagnosis cases inconclusive or doubtful cytopathologic analysis.We prospectively included 186 patients a mass (103 men; mean age: 62 y). Cytopathology and mutations, using TaqMan MGB allelic discrimination, were performed on EUS-FNA material. A final was obtained from...
To identify demographic and ultrasonographic (US) features associated with malignancy after initially nondiagnostic results of fine-needle aspiration (FNA) to help clarify the role repeat FNA, surgical excision, or serial US in these nodules.This study was HIPAA compliant institutional review board approved; informed consent waived. Thyroid nodules (n = 5349) that underwent US-guided FNA 2004-2012 were identified; 393 single but adequate cytologic, surgical, follow-up. Demographic...
Immunohistochemistry (IHC) and/or MSI-PCR (microsatellite instability-polymerase chain reaction) tests are performed routinely to detect mismatch repair deficiency (MMR-D). Classical MMR-D tumors present a loss of MLH1/PMS2 or MSH2/MSH6 with MSI-High. Other profiles have been described but rarely studied. In this study, we established classification unusual and determined their frequency clinical impact. All identified between 2007 2017 were selected. Any profile besides the classical...
Gastrointestinal (GI) bleeding is a common potentially life-threatening medical condition frequently requiring multidisciplinary collaboration to reach the proper diagnosis and guide management. GI can be overt (eg, visible hemorrhage such as hematemesis, hematochezia, or melena) occult positive fecal blood test iron deficiency anemia). Upper bleeding, which originates proximal ligament of Treitz, more than lower arises distal Treitz. Small bowel accounts for 5-10% cases commonly manifesting...
Morphologic Features of 211 Adrenal Masses at Initial Contrast-Enhanced CT: Can We Differentiate Benign From Malignant Lesions Using Imaging Alone?Julie H. Song1, David J. Grand1, Michael D. Beland1, Kevin Chang1, Jason T. Machan2,3 and William W. Mayo-Smith1Audio Available | Share