A5069855363- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Colorectal and Anal Carcinomas
- Pancreatitis Pathology and Treatment
- Appendicitis Diagnosis and Management
- Neuroendocrine Tumor Research Advances
- Cardiac, Anesthesia and Surgical Outcomes
- Enhanced Recovery After Surgery
- Renal and related cancers
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Venous Thromboembolism Diagnosis and Management
- Pain Mechanisms and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Inflammatory Bowel Disease
- Surgical Simulation and Training
- Endometriosis Research and Treatment
Centre Hospitalier Universitaire de Toulouse
2012-2025
Centre Hospitalier Universitaire de Bordeaux
2016-2025
Université de Toulouse
2014-2024
Inserm
2005-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2022-2024
École Nationale Vétérinaire de Toulouse
2021-2024
Centre de Recherche en Cancérologie de Toulouse
2012-2024
Centre National de la Recherche Scientifique
2024
Digestive Health Research Institute
2020-2024
Université Toulouse III - Paul Sabatier
2021-2024
We studied the efficacy of octreotide treatment on hypoglycaemia in patients with insulinoma and its relationships Octreoscan scintigraphy presence tumoral somatostatin receptors sst2A sst5.17 were evaluated using (i) evaluation blood glucose, insulin C-peptide during a short 100 mug test fasting and/or over 8 days-8 months octreotide, (ii) (iii) immunostaining tumor anti-sst2A anti-sst5.Octreotide was effective 10/17 patients. detected 4/17 insulinomas. receptor 7/17 insulinomas sst5 15/17...
Laparoscopic sphincter preservation for low rectal cancer is challenging because of the high risk positive circumferential resection margin. We hypothesized that perineal dissection distal rectum may improve quality surgery, compared with conventional abdominal dissection.Between 2008 and 2012, 100 patients (< 6 cm from anal verge) suitable were randomized between dissection. Surgery included laparoscopic mobilization left colon Distal was performed laparoscopically in group transanally...
Expediting the diagnosis of pancreatic ductal adenocarcinoma (PDAC) would benefit care management, especially for start treatments requiring histological evidence. This study evaluated combined diagnostic performance circulating biomarkers obtained by peripheral and portal blood liquid biopsy in patients with resectable PDAC.Liquid biopsies were performed a prospective translational clinical trial (PANC-CTC #NCT03032913) including 22 PDAC 28 noncancer controls from February to November 2017....
Obesity is associated with increased technical difficulty in laparoscopic surgery. However, its impact has been measured mainly for colectomy but not specifically rectal excision. The aim of the study was to assess body mass index (BMI) on feasibility and oncological outcome excision cancer.A total 490 patients treated by cancer from January 1999 June 2010 were included. Seventy per cent had preoperative radiochemotherapy. Patients separated into four groups according BMI (kg/m(2) ): < 20,...
Tumor-released extracellular vesicles (EVs) contain tumor-specific cargo distinguishing them from healthy EVs, and making eligible as circulating biomarkers. Glypican 1 (GPC1)-positive exosome relevance liquid biopsy elements is still debated. We carried out a prospective study to quantify GPC1-positive exosomes in sera pancreatic ductal adenocarcinoma (PDAC) patients undergoing up-front surgery, compared controls including without cancer history displaying preneoplasic lesions. Sera were...
Immunohistochemistry (IHC) and/or MSI-PCR (microsatellite instability-polymerase chain reaction) tests are performed routinely to detect mismatch repair deficiency (MMR-D). Classical MMR-D tumors present a loss of MLH1/PMS2 or MSH2/MSH6 with MSI-High. Other profiles have been described but rarely studied. In this study, we established classification unusual and determined their frequency clinical impact. All identified between 2007 2017 were selected. Any profile besides the classical...
Objective Despite guidelines indicating no contraindications for contraceptives in women with inflammatory bowel disease (IBD), this population shows increased voluntary childlessness and lower contraceptive use. Knowledge gaps among healthcare providers on IBD’s impact fertility contraception may drive these trends. This survey assessed knowledge discrepancies IBD patients, gastroenterologists (GEs), women’s (WHPs) regarding contraception. Methods An anonymous was conducted between August...
The intestinal epithelium has to maintain a tight barrier the harsh luminal environment. absorptive enterocytes have polygonal and columnar shape, while mucus-producing goblet cells round apical cell shape bulky body, raising question of how epithelial integrity is maintained around these cells. Here, we show that induce junction fractures between neighboring under homeostatic conditions in vivo. Through theoretical modeling experimental perturbations, demonstrate arise from two-component...
Abstract Background and objectives Pancreaticoduodenectomy (PD) remains a morbid surgery. Preoperative biliary drainage (PBD) is often necessary before surgery but associated with contamination. We compared the postoperative complications of patients undergoing PBD who received usual prophylactic antibiotics (PAs) or systematic antibiotherapy (ABT). Methods All underwent between 2008 2017 were included. Systematic perioperative ABT piperacillin + tazobactam (ABT group) was implemented in...
Imbalance between proteases and their inhibitors plays a crucial role in the development of Inflammatory Bowel Diseases (IBD). Increased elastolytic activity is observed colon patients suffering from IBD. Here, we aimed at identifying players involved hyperactivity associated with IBD contribution to disease. We revealed that epithelial cells are major source healthy human colonic tissues this greatly increased patients, both diseased distant sites inflammation. This study identified...