A5012124988- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
- Semiconductor Quantum Structures and Devices
- SARS-CoV-2 and COVID-19 Research
- Acute Kidney Injury Research
- Advanced Semiconductor Detectors and Materials
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Renal and Vascular Pathologies
- Complement system in diseases
- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Liver Disease and Transplantation
- Vasculitis and related conditions
- Quantum and electron transport phenomena
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Chronic Kidney Disease and Diabetes
- Biochemical and Molecular Research
- Electrolyte and hormonal disorders
University Hospital Heidelberg
2016-2025
Heidelberg University
2016-2025
German Center for Infection Research
2021-2025
Medizinische Hochschule Hannover
2024
Nierenzentrum Heidelberg
2009-2024
Apogenix (Germany)
2019-2022
Goethe University Frankfurt
2018
United States Air Force Research Laboratory
2001-2015
Kirtland Air Force Base
2001-2015
Heidelberg University
2011-2015
The relationship among insulin resistance, adiponectin, and cardiovascular (CV) morbidity in patients with mild moderate kidney disease was investigated. Insulin sensitivity (Homeostasis Model Assessment of Resistance [HOMA-IR]) adiponectin plasma levels were assessed 227 nondiabetic renal at different degrees dysfunction 76 healthy subjects similar age gender distribution body mass index. In patients, association prevalent CV events evaluated, incident evaluated a prospective study. HOMA-IR...
Reduced bioavailability of nitric oxide (NO) is thought to play an important role in progression renal damage. The hypothesis that the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA) involved kidney disease was tested. Plasma ADMA concentrations and other putative factors were assessed 227 relatively young patients (45.7 ± 12.6 yr) with nondiabetic diseases mild moderate failure. Progression as doubling serum creatinine and/or replacement therapy evaluated prospectively....
It was reported recently that treatment of kidney transplant recipients with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II type 1 receptor blockers (ARB) is associated strikingly improved long-term graft and patient survival. This finding has important implications for future posttransplantation therapy recommendations. In an analysis 17,209 1744 heart recipients, association ACEI/ARB outcome could not be confirmed. concluded recommendations a widespread use in are unwarranted.
Electron-hole bilayers are expected to make a transition from pair of weakly coupled two-dimensional systems strongly exciton system as the barrier between layers is reduced. Coulomb drag measurements on devices with 30 nm consistent two 2D Fermi where decreases temperature. For 20 barrier, however, we observe an increase in resistance temperature reduced when current driven electron layer and voltage measured hole layer. These results indicate onset strong coupling possibly due formation or...
Acute kidney injury (AKI) is associated with a high mortality of up to 60%. The mode renal replacement therapy (intermittent versus continuous) has no impact on patient survival. Sustained low efficiency dialysis using single-pass batch system (SLED-BD) recently been introduced for the treatment dialysis-dependent AKI. To date, however, only limited evidence available in comparison SLED-BD continuous veno-venous hemofiltration (CVVH) intensive care unit (ICU) patients AKI.Prospective,...
Reports from experienced centers suggest that recipients of an ABO-incompatible living-donor kidney transplant after reduction ABO antibodies experience no penalty in graft and patient survival versus ABO-compatible transplants, but confirmation these results can be widely replicated is lacking.Living-donor transplants donors antibody registered with the Collaborative Transplant Study during 2005 to 2012 were analyzed compared (i) a matched group (ii) all performed at least five grafts study...
It is a matter of debate whether pancreas allografts independently contribute to renal allograft and patient survival in individuals who have type 1 diabetes receive simultaneous kidney transplant (SPK). Using data from the Collaborative Transplant Study, we studied patients had were recipients deceased-donor kidneys (DDK), living-donor (LDK), or SPK. We analyzed graft rates with maximum 18 yr follow-up. DDK inferior compared LDK SPK recipients. superior initially, but demonstrated equal...
Background and objectives Patients receiving hemodialysis are at high risk for both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disease 2019. A lifesaving vaccine is available, but sensitivity to vaccines generally lower in patients on dialysis. Little yet known about antibody responses after 2019 (COVID-19) vaccination this vulnerable group. Design, setting, participants, measurements In prospective single-center study, we included 22 dialysis 46 healthy controls...
Despite limited data on safety and immunogenicity, heterologous prime-boost vaccination is currently recommended for individuals with ChAdOx1 nCoV-19 prime immunization in certain age groups. In this prospective, single-center study we included 166 health care workers from Heidelberg University Hospital who received either nCoV-19/BNT162b2, homologous BNT162b2 or between December 2020 May 2021. We measured anti-S1 IgG, SARS-CoV-2 specific neutralizing antibodies, antibodies against different...
Seroconversion after COVID-19 vaccination is impaired in kidney transplant recipients. Emerging variants of concern such as the B.1.617.2 (delta) and B.1.1.529 (omicron) pose an increasing threat to these patients. In this observational cohort study, we measured anti-S1 IgG, surrogate neutralizing, anti-receptor-binding domain antibodies three weeks a third mRNA vaccine dose 49 recipients compared results 25 age-matched healthy controls. addition, vaccine-induced neutralization SARS-CoV-2...
Acute kidney injury (AKI) secondary to sepsis results in poor outcomes and conventional function indicators lack diagnostic value. Soluble urokinase plasminogen activator receptor (suPAR) is an innate immune-derived molecule implicated inflammatory organ damage. We characterized the ability of longitudinal serum suPAR levels discriminate severity course sepsis-induced AKI (SI-AKI) 200 critically ill patients meeting Sepsis-3 criteria. The pathophysiologic relevance varying SI-AKI was...
Normal incidence InAs/In0.15Ga0.85As dots-in-a-well detectors operating at T=78 K with λp∼7.2 μm and a spectral width (Δλ/λ) of 35% are reported. The peak 7.2 is attributed to the bound-to-bound transitions between ground state dot states within InGaAs well. A broad shoulder around 5 μm, which bound-to-continuum transition, also observed. Calibrated blackbody measurements device temperature 78 yield responsivity 3.58 A/W (Vb=−1 V), detectivity=2.7×109 cm Hz1/2/W (Vb=−0.3 conversion...
Peritoneal dialysis is limited by morphologic changes of the peritoneal membrane. Use fluids (PDF) that contain glucose degradation products (GDP) generates advanced glycation end-products (AGE) within cavity. It unknown whether damage causally related to AGE–receptor for AGE (RAGE) interaction. The effects PDF were compared with different amounts GDP on membrane in 48 wild-type (WT) and RAGE-deficient mice. (1 ml) instilled twice daily over a period 12 wk. Groups eight animals each received...
The exquisitely sensitive single antigen bead (SAB) technique was shown to detect human leukocyte (HLA) antibodies in sera of healthy male blood donors. Such false reactions can have an impact on critical decisions, especially with respect the determination unacceptable HLA-antigen mismatches patients awaiting a kidney transplant. We tested pretransplant 534 waiting list using complement-dependent cytotoxicity (CDC), enzyme-linked immunosorbent assay (ELISA) and SAB parallel. Evidence HLA...
The association of donor-specific HLA antibodies (DSA) with kidney graft failure has been addressed previously; however, the majority studies were based on small numbers patients failure.We investigated 83 failed transplants for a possible de novo development and persistence or loss pre-existing DSA failure. Single Antigen Bead assay-detected non-DSA compared between matched controls functioning grafts.The incidence weak at mean fluorescence intensity 500 higher was in than nonrejector group...
Background: Cardiac manifestation of COVID-19 has been reported during the COVID pandemic. The role cardiac arrhythmias in is insufficiently understood. This study assesses incidence and their prognostic implications hospitalized COVID-19-patients. Methods: A total 166 patients from eight centers who were for 03/2020–06/2020 included. Medical records systematically analyzed baseline characteristics, biomarkers, clinical outcome parameters related to index hospitalization. Predisposing risk...
Abstract. In the reaction of kidneys to injury, cytokine-driven proliferation plays an important role and precedes development glomerulosclerosis. There is great interest in agents that may interfere with such proliferation. Therefore, a rat model mesangioproliferative glomerulonephritis (induced by anti-Thy1.1) was studied, effects all- trans -retinoic acid (all- -RA) isotretinoin, powerful antiproliferative anti-inflammatory substances, on glomerular damage cell were examined....
Abstract The relative risk for the development of malignancies following solid organ transplantation seems to be decreased in patients treated with immunosuppressive agent mycophenolic acid (MPA). However, molecular mechanisms antineoplastic effects MPA are not completely understood. Here, we report that human endothelial cells and fibroblasts highly sensitive treatment. We found U87 glioblastoma were resistant treatment vitro. tumor growth was markedly inhibited vivo BALB/c nude mice,...