A5043939891- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Vasculitis and related conditions
- Cancer-related molecular mechanisms research
- Renal and Vascular Pathologies
- Atherosclerosis and Cardiovascular Diseases
- Abdominal vascular conditions and treatments
- Autophagy in Disease and Therapy
- Peripheral Artery Disease Management
- Eosinophilic Esophagitis
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Vestibular and auditory disorders
- Infectious Aortic and Vascular Conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Tracheal and airway disorders
- Cerebrovascular and Carotid Artery Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Galectins and Cancer Biology
- Diet, Metabolism, and Disease
- Vascular Anomalies and Treatments
- MicroRNA in disease regulation
- Hepatitis C virus research
- IL-33, ST2, and ILC Pathways
- Dermatologic Treatments and Research
Peking University
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Center for Life Sciences
2025
Peking Union Medical College Hospital
2017-2025
Beijing Hospital
2018-2024
Technical University of Munich
2019-2024
Shanghai University of Traditional Chinese Medicine
2024
Institute of Computing Technology
2024
Chinese Academy of Sciences
2011-2024
Shuguang Hospital
2024
Long noncoding RNAs (lncRNAs) are important regulators of biological processes involved in vascular tissue homeostasis and disease development. The present study assessed the functional contribution lncRNA myocardial infarction-associated transcript (MIAT) to atherosclerosis carotid artery disease. We profiled differences RNA expression patients with advanced atherosclerotic lesions from Biobank Karolinska Endarterectomies. MIAT was identified as most upregulated plaques compared...
POSTN (Periostin) is an ECM (extracellular matrix) protein involved in tissue remodeling response to injury and a contributing factor tumorigenesis, suggesting that plays role the pathogenesis of pulmonary hypertension (PH).We aimed gain insight into mechanistic contribution experimental mouse models PH correlate these findings with humans.We used genetic epistasis approaches human artery endothelial cells (hPAECs), smooth muscle cells, (Sugen 5416/hypoxia or chronic hypoxia) discern its...
Vascular calcification can be enhanced by hyperglycemia. Elastin loss in tunica media promotes the osteogenic transformation of smooth muscle cells (SMCs) and involves arterial medial (AMC) that is associated with a high incidence cardiovascular risk patients type 2 diabetes. Here, we tested whether hydrogen sulfide (H2S), an endogenous gaseous mediator, prevent elastin attenuate induced glucose SMCs. Calcification was (4500 mg/L) human aortic SMCs (HASMCs) under condition calcifying medium...
Abstract Aims Atherosclerotic cerebrovascular disease underlies the majority of ischaemic strokes and is a major cause death disability. While plaque burden predictor adverse outcomes, vulnerability increasingly recognized as driver lesion rupture risk for clinical events. Defining molecular regulators carotid instability could inform development new biomarkers and/or translational targets at-risk individuals. Methods results Using two independent human endarterectomy biobanks, we found that...
In this study, organ-on-chip technology is used to develop an in vitro model of medium-to-large size arteries, the artery-on-a-chip (AoC), with objective recapitulate structure arterial wall and relevant hemodynamic forces affecting luminal cells. AoCs exposed either vivo-like shear stress values or kept static conditions are assessed generate a panel novel genes modulated by stress. Considering crucial role played alterations carotid arteries affected atherosclerosis (CAD) abdominal aortic...
Triple-negative breast cancer (TNBC) a highly aggressive tumor entity with an unfavorable prognosis, is treated by multimodal therapies, including ionizing radiation (IR). Radiation-resistant cells, as well induced normal tissue toxicity, contribute to the poor clinical outcome of disease. In this study, we investigated potential novel hybrid iron oxide (Fe3O4)-gold (Au) nanoparticles (FeAuNPs) functionalized heat shock protein 70 (Hsp70) tumor-penetrating peptide (TPP) and coupled via PEG4...
Nitroxyl (HNO), one-electron reduced and protonated sibling of nitric oxide (NO), is a potential regulator cardiovascular functions. It produces positive inotropic, lusitropic, myocardial anti-hypertrophic vasodilator properties. Despite these favorable actions, the significance possible mechanisms HNO in diabetic hearts have yet to be fully elucidated. H9c2 cells or primary neonatal mouse cardiomyocytes were incubated with normal glucose (NG) high (HG). Male C57BL/6 mice received...
Imaging techniques such as computed tomographies (CT) play a major role in clinical imaging and diagnosis of malignant lesions. In recent years, metal nanoparticle platforms enabled effective payload delivery for several techniques. Due to the possibility surface modification, nanoparticles are predestined facilitate molecular tumor targeting. this work, we demonstrate feasibility anti-plasma membrane Heat shock protein 70 (Hsp70) antibody functionalized gold (cmHsp70.1-AuNPs) tumor-specific...
Although it has been established that cannabidiol (CBD), the major non-psychoactive constituent of cannabis, exerts antitumoral activities, exact mechanism(s) via which tumor cells are killed by CBD not well understood. This study provides new insights into potential mechanisms CBD-induced mutual antagonism apoptosis and macroautophagy using wild type (HCT116 p53wt, LS174T p53wt), knockout p53-/-) mutant (SW480 p53mut) human colorectal cancer (CRC). causes a more pronounced loss in viability...
Activation of NKAα1-dependent autophagy ameliorates α-synuclein pathology.
In the fall of 2003, a two-year-old tiger named Ming, weighing some four hundred pounds, was discovered living in an apartment Harlem, New York. Ming's rescue by NYPD witnessed, recalled, and venerated scores neighbors. The tiger's history ancestry stimulated considerable media interest, investigative sleuthing, forensic genomic analyses. Harlem subspecies makeup, his relationship to putative sibling Cheeky Homestead, Florida, genetic distinctiveness from wild tigers assessed Whole Genome...
We address the challenge of minimizing true risk in multi-node distributed learning. These systems are frequently exposed to both inter-node and intra-node label shifts, which present a critical obstacle effectively optimizing model performance while ensuring that data remains confined each node. To tackle this, we propose Versatile Robust Label Shift (VRLS) method, enhances maximum likelihood estimation test-to-train density ratio. VRLS incorporates Shannon entropy-based regularization...
This study aimed to investigate the influence of cancer type on radiotherapy-induced otitis media with effusion (RTOME) occurrence and assess impact anatomical region-specific radiation exposure both RTOME incidence rates associated pathogenic processes. A retrospective analysis was conducted 1046 head neck (HNC) patients who underwent radiotherapy at Peking Union Medical College Hospital between 2016 2023. The assessed across various types, probabilities different regions were compared...
The fragmentation pathways of oxygenated tetracyclic triterpenoids from Ganoderma lucidum were systematically studied based on interpreting the mass spectra 44 known using a combination multistage tandem spectrometry (MS n ) experiments and high‐resolution (HRMS) analysis. In negative ion mode, triterpenoid acids are rather characteristic. After prominent loss H 2 O or CO , cleavages take place A, B, C D rings. Interestingly, cleavage mode is highly dependent positions carbonyl groups...
The prolongation of QT intervals in both mothers and fetuses during the later period pregnancy implies that higher levels progesterone may regulate function human ether-a-go-go-related gene (HERG) potassium channel, a key ion channel responsible for controlling length intervals. Here, we studied effect on expression, trafficking, HERG channels underlying mechanism. Treatment with 24 h decreased abundance fully glycosylated form rat neonatal cardiac myocytes HERG-HEK293 cells, cell line...
The treatment of malignant stenosis involving the carina or bronchi is challenging due to complicated anatomy with individual variation, which makes it necessary customize stents for each patient. Therefore, this study aims evaluate feasibility a novel metallic segmented airway stent customized aid three-dimensional (3D) printing such cases.The were individually 3D printed mold based on computed tomography (CT) images according anatomical features airway. A design was applied junction part...