A5101518361- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Immune cells in cancer
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Mast cells and histamine
- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Hepatitis B Virus Studies
- Urticaria and Related Conditions
- Helicobacter pylori-related gastroenterology studies
- Inflammation biomarkers and pathways
- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- Psoriasis: Treatment and Pathogenesis
- Garlic and Onion Studies
- X-ray Diffraction in Crystallography
- Advanced NMR Techniques and Applications
- Autophagy in Disease and Therapy
- Nanoparticle-Based Drug Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Advanced MRI Techniques and Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
China Medical University
2024
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
Guangzhou Medical University
2019-2020
Guangzhou Women and Children Medical Center
2019
Abstract The response rate of pancreatic cancer to chemotherapy or immunotherapy is low. Although minimally invasive irreversible electroporation (IRE) ablation a promising option for irresectable cancers, the immunosuppressive tumour microenvironment that characterizes this type enables recurrence. Thus, strengthening endogenous adaptive antitumour immunity critical improving outcome therapy and post-ablation immune therapy. Here we present hydrogel microsphere vaccine amplifies anti-cancer...
Background and Aims Primary hepatocellular carcinoma (HCC) is usually presented in inflamed fibrotic/cirrhotic liver with extensive lymphocyte infiltration. We examined the associations between HCC early recurrence alterations serum levels of inflammatory cytokines. Methods A cohort 105 patients chronic hepatitis B virus infection were included. Pre-therapy, we quantified their concentrations Th1-, Th2-, Th17-, Treg-related, other cytokines that have been reported to be associated poor...
Cancer vaccines can amplify existing antitumor responses or prime naïve T cells to elicit effector T-cell functions in patients through immunization. Antigen-specific CD8+ are crucial for the rejection of established tumors. We constructed XCL1-GPC3 fusion molecules as a liver cancer vaccine by linking XCL1 chemokine glypican-3 (GPC3), which is overexpressed hepatocellular carcinoma (HCC). Cells expressing chemoattracted murine XCR1+CD8α+ dendritic (DC) and human XCR1+CD141+ DCs vitro...
Abstract Background: Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury that has high mortality rate and leads to substantial healthcare costs. MicroRNA-124-3p (miR-124-3p) helps suppress inflammation during pulmonary injury. However, its mechanism action largely unknown, role in ARDS remains be determined. Methods: Mice NR8383 cells were exposed lipopolysaccharides (LPS) induce ARDS, their miR-124-3p levels After miRNA agomir was administrated the mice,...
Arterial wall inflammation and remodelling are the characteristic features of Takayasu's arteritis (TAK). It has been proposed that vascular smooth muscle cells (VSMCs) main targeted inflammatory damage participate in arterial TAK. Whether VSMCs actively involved not elucidated. Studies have shown cellular senescence tissue is closely related to local persistence. We aimed investigate whether contributes prosenescent factors
Mast cells (MCs) have been reported to be one of the important immunoregulatory in promoting development colitis-related colon cancer (CRC). It is not clear which MC subtypes play critical roles CRC progression from colitis because mucosal mast (MMCs) are distinct connective tissue (CTMCs) maintaining intestinal barrier function under homeostatic and inflammatory conditions. In current study, we found that MMC numbers gene expressions MMC-specific proteases increased significantly an induced...
Aflatoxin exposure increases the risk for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected individuals, particularly males. We investigated sex-based differences HCC genome and antitumor immunity.Whole-genome, whole-exome, RNA sequencing were performed on 101 patient samples (47 males, 54 females) that resulted from HBV infection aflatoxin Qidong. Androgen expression of metabolism-related genes nonhomologous DNA end joining (NHEJ) factors examined HBV-positive cell lines,...
Iron nanoparticles have an increasingly more and important role in MR molecular imaging due to their novel magnetic surface chemical properties. They provide new possibilities for noninvasive diagnosis treatment monitoring, especially tissues that are rich macrophages. The smaller size prolongation of the plasma half-life change vivo fate ultrasmall superparamagnetic iron oxide (USPIO) captured by liver reticuloendothelial system (RES) or mononuclear phagocytic (MPS). However, there is still...
BACKGROUND:Recent studies have proved that autophagy dysfunction in proinflammatory cells is involved tissue damage and an excessive inflammatory response sepsis. In the present study, we identified human antimicrobial peptide LL-37 facilitates resistance to DNase II-induced mitochondrial DNA (mtDNA) degradation subsequent autophagy. MATERIAL AND METHODS:We found higher serum levels of patients with severe sepsis compared mild Neutrophils isolated from mice after treatment Cramp-mtDNA...
Ulcerative colitis (UC) is a group of chronic inflammatory bowel disease (IBD) mainly affecting the colon. The exact etiology ulcerative remains elusive. CD131 receptor subunit mediating effects hematopoietic growth factors GM-CSF and IL-3, which regulate various responses. pleiotropic cytokines on intestinal inflammation suggest that additional influence their overall function, where may play role.In present study, we investigated role in pathogenesis colitis, with use murine model...
Background: Chronic inflammation is one of the important mediators colitis-related colon cancer (CRC). Abundant mast cells (MCs) were observed in tumor microenvironment and released upon MC activation play an role process chronic inflammation. Previously, we found that intestine mucosal MCs recruited modulated inflammatory CD11b+Gr1+ to promote CRC development. In current study investigated effects Vam3, a resveratrol dimer with potent anti-inflammatory effects, on Methods: RBL-2H3 cells,...
Abstract Background Ulcerative colitis (UC) is a group of chronic inflammatory bowel disease (IBD) mainly affecting the colon. The exact etiology ulcerative remains elusive. CD131 receptor subunit mediating effects hematopoietic growth factors GM-CSF and IL-3, which regulate various responses. pleiotropic cytokines on intestinal inflammation suggest that additional influence their overall function, where may play role. Methods In present study, we investigated role in pathogenesis colitis,...
Ulcerative colitis (UC) is a group of chronic inflammatory bowel disease (IBD) mainly affecting the colon. The exact etiology ulcerative remains elusive. CD131 receptor subunit mediating effects hematopoietic growth factors GM-CSF and IL-3, which regulate various responses. pleiotropic cytokines on intestinal inflammation suggest that additional influence their overall function, where may play role.In present study, we investigated role in pathogenesis colitis, with use murine model...