A5108056359- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Advanced Proteomics Techniques and Applications
- Cancer-related molecular mechanisms research
- Caveolin-1 and cellular processes
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Pancreatitis Pathology and Treatment
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Barrier Structure and Function Studies
- Renal cell carcinoma treatment
- Melanoma and MAPK Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- S100 Proteins and Annexins
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
China Medical University
2016-2025
Zunyi Medical University
2025
Institute of Animal Sciences
2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Central South University
2012-2023
Xiangya Hospital Central South University
2012-2023
Shandong University of Traditional Chinese Medicine
2022
Sheng Jing Hospital
2022
Guangxi University of Chinese Medicine
2021-2022
Pancreatic cancer is one of the deadliest cancers with rapid disease progression. Further elucidation its underlying molecular mechanisms and novel biomarkers for early detection necessary. Exosomes are small extracellular vesicles that released by multiple cell types acting as message carriers during intercellular communication promising biomarker candidates. However, role pancreatic cell-derived exosomes in progression application these diagnostic have not been fully studied. In this...
Pancreatic cancer (PC) is a devastating malignant disease with poor prognosis. This study aimed to investigate the role of urothelial carcinoma associated 1 (UCA1) in progression PC. Our results revealed that long noncoding RNA (lncRNA) UCA1 was overexpressed PC tissues compared adjacent histologically normal tissues. A downregulated level also detected five human cell lines (SW1990, BxPC-3, MiaPaCa-2, PANC-1, and CAPAN-1) pancreatic duct epithelial HPDE cells. The proliferation cells...
Pancreatic cancer is one of the most malignant tumors. Invasion and metastasis can occur in early stage pancreatic cancer, contributing to poor prognosis. Accordingly, this study, we evaluated molecular mechanisms underlying invasion metastasis. Using mass spectrometry, found that Integrin alpha 6 (ITGA6) was more highly expressed a invasive cell line (PC-1.0) than less (PC-1). Through vitro vivo experiments, observed significant decreases cells after inhibiting ITGA6. Based on data TCGA,...
Objectives: This study aimed to perform a multicenter comparison between robotic pancreaticoduodenectomy (RPD) and open (OPD). Background: Previous comparisons of RPD versus OPD have only been carried out in small, single-center studies variable quality. Methods: Consecutive patients who underwent (n = 1032) or 1154) at 7 centers China July 2012 2020 were included. A 1:1 propensity score matching (PSM) was performed. Results: After PSM, 982 each group enrolled. The had significantly lower...
Abstract Background Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is difficult due to the lack effective screening tests. CA199, standard biomarker for PDAC management, not sufficiently reliable early diagnosis. This prospective study aimed evaluate whether circulating tumor cells (CTCs) could complement or perform better than CA199 in determining PDAC. Methods A total 168 blood samples were collected from 80 patients with PDAC, 32 acute pancreatitis, 22 benign masses, and 34...
Pancreatic cancer is known to have a high mortality rate, and its early diagnosis remains challenging due the occult location of pancreas. Exosomes derived from pancreatic cells specifically express glypican-1, which may provide liquid biopsy opportunity for cancer. Herein, an inductively coupled plasma mass spectrometry (ICP-MS) photothermal dual-readout platform was proposed ultrasensitive point-of-care analysis exosomes. In our design, exosomes were captured by sandwich immunoassay,...
Hepatocellular carcinoma (HCC) remains a growing threat to global health. Necroptosis is newly discovered form of cell necrosis that plays vital role in cancer development. Thus, we conducted this study identify predictive signature HCC based on necroptosis-related genes.The tumor samples the liver hepatocellular (LIHC) cohort from The Cancer Genome Atlas (TCGA) database were subtyped using consensus clustering algorithm. Univariate Cox regression and LASSO-Cox analysis performed gene genes...
To investigate the potential prognostic value of LDHA in lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC).Molecular, clinicopathological survival data Cancer Genome Atlas-Lung were obtained for secondary analysis.LDHA expression was significantly upregulated both LUAD LUSC compared with normal tissues. tissues had even higher Increased an independent indicator terms overall (hazard ratio: 1.547, 95% CI: 1.253-1.911; p < 0.001) recurrence-free 1.486, 1.161-1.900; = 0.002) LUAD,...
Pancreatic cancer is a highly metastatic and chemo-resistant disease. Secreted proteins involved in cell-cell interactions play an important role changing the tumor microenvironment. Previous studies generally focus on secretome of cell line from serum-free media, due to serious interference fetal bovine serum (FBS). However, serum-starvation may alter expression patterns secreted proteins. Hence, efforts decrease proteomic analysis serum-containing media have been hampered quantitatively...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors known, with an overall 5-year survival rate less than 6% due to early local invasion and distant metastasis. Exploring suitable therapeutic targets associated metastasis required for improving prognosis PDAC. In this study, we investigated role glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) in PGAM1 expression was examined tissue samples 54 PDAC patients using immunohistochemistry, correlation between...
Pancreatic cancer (PC), a malignancy of the digestive system, has one highest rates metastasis and mortality. It is characterized by detachment, migration, implantation infiltration tumor cells to form metastases or recurrent foci. Tetraspanin 1 (TSPAN1), novel member TSPAN superfamily, highly expressed in many types cancer, including gastric, colon, liver esophageal cancer. also been associated with lymph node metastasis, recurrence metastasis. However, role TSPAN1 PC not fully elucidated....
To clarify the involvement of matrix metalloproteinase-7 (MMP-7) in cell dissociation and subsequent invasion pancreatic cancer cells.Western blotting, vitro assay, immunocytochemistry, immunohistochemistry were performed lines or tissue.The active form MMP-7 protein was expressed exclusively conditioned medium dissociated (PC-1.0 AsPC-1) cells, whereas proMMP-7 only detected non-dissociated (PC-1 Capan-2) cells. Both intracellular localised greatly reduced by treatment with epidermal growth...
Pancreatic cancer is the fourth leading cause of death, with a 5-year survival rate only 1–4%. Integrin-mediated cell adhesion critical for initiation, progression, and metastasis cancer. In this study we investigated role integrin b4 (ITGB4) its phosphorylation at tyrosine Y1510 (p-ITGB4-Y1510) in tumorigenesis pancreatic We analyzed expression ITGB4 p-ITGB4-Y1510 tissue lines using immunohistochemistry, Western blot, or semi-quantitative reverse transcription PCR. were highly expressed (n...
Aberrant expression of microRNAs contributes to the progression pancreatic cancer by targeting downstream genes. A novel regulatory axis, miR-1224-5p/ELF3, was identified bioinformatic analysis and experimental verification. Studies underlying molecular mechanisms behind this axis lead a better understanding development cancer.The differential miR-1224-5p ELF3 verified based on Gene Expression Omnibus (GEO) datasets clinical samples. The relationship between demonstrated luciferase assay...
Aim: Integrated analysis of genomics, epigenomics, transcriptomics and clinical information contributes to identify specific molecular subgroups find novel biomarkers for pancreatic cancer. Materials & methods: The DNA copy number variation, the simple nucleotide methylation mRNA data cancer patients were obtained from Cancer Genome Atlas. Four (iC1, iC2, iC3 iC4) identified by integrating analysis. Results: iC1 subgroup harbors better prognosis, higher immune score, lesser variation...
BACKGROUND Middle pancreatectomy (MP) is a surgical procedure that removes non-invasive lesions in the pancreatic neck and body, allowing for preservation of function. However, MP associated with higher risk postoperative complications, there’s no clear consensus on which anastomotic method preferable. In recent years, our team has developed new called interlocking main duct-jejunal (IMPD-J) internal bridge drainage to MP. AIM To compare perioperative outcomes patients who underwent IMPD-J...
Objective This study aimed to develop Benefit Finding intervention protocols for colorectal cancer patients on psychological management in China. Methods We created an initial draft of such a protocol through comprehensive literature review and group discussions. A two-round Delphi via WeChat correspondence was conducted, with 14 Chinese experts. Experts rated scored the importance indicators five-point Likert scale. Results The response rates two rounds both were 100%(n=14), authority...