A5102024875- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Colorectal Cancer Surgical Treatments
- Caveolin-1 and cellular processes
- Virus-based gene therapy research
- Colorectal Cancer Screening and Detection
- Cancer Research and Treatments
- Circular RNAs in diseases
- MicroRNA in disease regulation
- PARP inhibition in cancer therapy
- Minimally Invasive Surgical Techniques
- Cell Adhesion Molecules Research
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Cancer Mechanisms and Therapy
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- vaccines and immunoinformatics approaches
Tianjin Anding Hospital
2024-2025
Tianjin Medical University
2024-2025
Sichuan University
2014-2024
Nanjing University of Posts and Telecommunications
2023
Liaoning Cancer Hospital & Institute
2017-2021
China Medical University
2006-2021
State Key Laboratory of Biotherapy
2014-2021
Cancer Hospital of Chinese Academy of Medical Sciences
2017
North Sichuan Medical University
2017
First Hospital of China Medical University
2014
Immunotherapy based on the immune checkpoint blockade has emerged as most promising approach for cancer therapy. However, proportion of colorectal patients who benefit from immunotherapy is small due to immunosuppressive tumor microenvironment. Hence, combination an ideal strategy overcome this limitation. In study, we developed a novel CSF-1R (colony-stimulating factor 1 receptor) inhibitor (PLX3397), oncolytic viruses, and anti-PD-1 antibody. Our results demonstrated that triple treatment...
Pancreatic cancer (PC) is a devastating malignant disease with poor prognosis. This study aimed to investigate the role of urothelial carcinoma associated 1 (UCA1) in progression PC. Our results revealed that long noncoding RNA (lncRNA) UCA1 was overexpressed PC tissues compared adjacent histologically normal tissues. A downregulated level also detected five human cell lines (SW1990, BxPC-3, MiaPaCa-2, PANC-1, and CAPAN-1) pancreatic duct epithelial HPDE cells. The proliferation cells...
Abstract Dexamethasone (Dex), as a pretreatment agent, is widely used to attenuate the side effects of chemotherapy in breast cancer treatment. However, whether and how Dex affects metastasis remain be furtherly understood. In this study, we established several mouse metastatic models study effect vitro vivo. Transwell, Western Blot RNA interference were applied molecular mechanism promoting cell migration. Meanwhile, on lung combined with PTX was discussed. Our results confirmed that could...
Pancreatic cancer (PC), a malignancy of the digestive system, has one highest rates metastasis and mortality. It is characterized by detachment, migration, implantation infiltration tumor cells to form metastases or recurrent foci. Tetraspanin 1 (TSPAN1), novel member TSPAN superfamily, highly expressed in many types cancer, including gastric, colon, liver esophageal cancer. also been associated with lymph node metastasis, recurrence metastasis. However, role TSPAN1 PC not fully elucidated....
Abstract Transcription factors are known to mediate the conversion of somatic cells induced pluripotent stem (iPSCs). factor TFAP2C plays important roles in regulation embryonic development and carcinogenesis; however, Tfap2c regulating cell reprogramming not well understood. Here we demonstrate is during generation iPSCs from mouse fibroblasts acts as a facilitator for formation. Mechanistically, c-Myc -dependent apoptosis, which roadblock reprogramming, can be significantly mitigated by...
Abstract Background To our knowledge, there are no studies to systematically compare the detailed clinical significance between curatively resected pancreatic head (ph) and body-tail (pbt) ductal adenocarcinoma based on new 8th edition of AJCC staging system (8th stage) that was just applied in practice 2018. Methods Three hundred fifty-one patients with (PC) from three center hospitals were entered into this multicenter cohort study. Results Increasing tumor size ( P < 0.001), T stage...
Abstract Background CD8 + T cell-mediated adaptive cellular immunity and natural killer (NK) innate both play important roles in tumour immunity. This study aimed to develop therapeutic vaccines based on double-activation of NK cells. Methods The immune Epitope database, Molecular Operating Environment software, enzyme-linked immunosorbent assay were used for epitope identification. Flow cytometry, confocal microscopy, UPLC-QTOF-MS, RNA-seq utilized evaluating PBMC-derived DCs, or cells...
Hepatocellular carcinoma (HCC) is one of the most common and deadly malignant tumors in world, especially China. Follistatin-like protein 5 (FSTL5) a member FSTL family, which involved cell proliferation, migration, differentiation, embryo development. We aimed to investigate function underlying mechanism FSTL5 HCC. expression was determined by immunohistochemistry staining liver cancer tissue microarray (TMA) correlation between prognosis HCC patients analysed. Further proliferation assay,...
Pancreatic cancer (PCC) is one of the most dangerous types tumor as it very difficult to treat and its 5‑year survival rate <6%. To date, there have been no effective therapeutic strategies PCC, thus, novel methods are required. Tetraspanin 1 (Tspan1) a member tetraspanins superfamily highly expressed in variety cancer, including gastric, hepatocellular colonic carcinomas. However, detailed functional role Tspan1 pancreatic cells still unclear further investigation required uncover potential...
The original article [1] contains errors in Figure 3i, 6c and S9: 1.In Fig. the legends of line chart were marked incorrectly.2. In 6c, panel ISA CD8a + group was unintentionally duplicated onto YL-ISA NK1.1 group.3. S9, LA-ISA Liver misused.
Background: Cell recognition molecule L1 (L1) plays an important role in cancer cell differentiation, proliferation, migration and survival, but its mechanism remains unclear. Methodology/Principal: Our previous study has demonstrated that enhanced survival neural cells by regulating surface glycosylation. In the present study, we show affected CHO (Chinese hamster ovary) line modulation of sialylation fucosylation at via PI3K (phosphoinositide 3-kinase) Erk (extracellularsignal-regulated...
Jun-Peng Pei, Rui Zhang, Nan-Nan Yong-Ji Zeng, Zhe Sun, Si-Ping Ma, Jian-Guo Zhou, Xin-Xiang Li, Jin Fan, Ji Zhu, Masanobu Abe, Zu-Bing Mei, Gang Shi, Chun-Dong Zhang
<title>Abstract</title> Prostate cancer (PCa) is the most common non-cutaneous malignancy and second leading cause of cancer-related death in men. Despite its prevalence, treatment outcomes are often unsatisfactory, necessitating search for more effective therapeutic approaches. mTOR inhibitor Rapamycin (RAPA) has shown promise managing PCa, but emergence resistance undermines long-term effectiveness. Recent studies suggest that PARP Olaparib (OLP) may overcome drug various tumor types. This...
Abstract Background To explore the potential therapeutic target to treat pancreatic cancers, Tspan1 was detected in human cancer tissue and ductal adenocarcinoma cells functional role of on proliferation explored mechanism investigated. Materials Methods PCC PDAC cell lines measured by qRT-PCR Western blot. knock-downed over-expressed via transfection with Tspan1-siRNA pLNCX-TSPAN1-cDNA, survival, cycle were MTT, Alamar blue Flow Cytometry assay. The mRNA protein expression assessed...
e15022 Background: In the past decade, cell-based immunotherapy has been reported to improve clinical outcomes by altering tumor immune responses, improving prognosis and overall survival rates in cancer patients.This retrospective study aimed evaluate efficacy of cytokine-induced killer (CIK) cell infusion as an adjuvant therapy patients with colorectal cancer. Methods: A total 370 admitted Cancer Hospital China Medical University, Liaoning & Insititute from March 2013 April 2015 were...
Objective To investigate the expression of absent in melanoma 2 (AIM2) and serum carcinoembryonic antigen (CEA) patients with colorectal cancer its clinical significance. Methods 118 tissues 50 normal were collected from Liaoning Cancer Hospital January 2010 to March 2013. The AIM2 was detected by immunohistochemistry. Clinical pathological parameters CEA levels retrospectively collected. correlation between level analyzed analysis, relationship two indicators clinicopathological...