A5100783336- S100 Proteins and Annexins
- Heat shock proteins research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Cellular Mechanics and Interactions
- Extracellular vesicles in disease
- Renal Diseases and Glomerulopathies
- Lipid metabolism and disorders
- Skin and Cellular Biology Research
- Galectins and Cancer Biology
- Cancer, Hypoxia, and Metabolism
- Chronic Kidney Disease and Diabetes
- Postcolonial and Cultural Literary Studies
- Hematopoietic Stem Cell Transplantation
- Glycosylation and Glycoproteins Research
- Cinema and Media Studies
- Byzantine Studies and History
- Mechanisms of cancer metastasis
- Autobiographical and Biographical Writing
- Metabolism, Diabetes, and Cancer
- Salivary Gland Tumors Diagnosis and Treatment
Sichuan University
2018-2025
Zhengzhou University
2023-2025
Children's Hospital of Capital Institute of Pediatrics
2025
First Affiliated Hospital of Zhengzhou University
2023-2025
Dalian Medical University
2013-2023
China Medical University
2023
State Key Laboratory of Oral Diseases
2021
Tianjin Medical University
2009
Tianjin Medical University General Hospital
2009
RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, function and molecular mechanism m5C tumor drug resistance remain unclear.The correlation between methylation, writer NOP2/Sun methyltransferase family member 2 (NSUN2) EGFR-TKIs was determined non-small-cell lung cancer (NSCLC) cell lines patient samples. The effects NSUN2 on were investigated by gain- loss-of-function assays vitro vivo. RNA-sequencing (RNA-seq), bisulfite sequencing...
Abstract Background RNA 5‐methylcytosine (m5C) plays an important role in the progression of hepatocellular carcinoma (HCC). Dysregulation ferroptosis is closely associated with HCC. However, effect epigenetic mRNA m5C modification on HCC remains unclear. Methods In this study, was evaluated by detecting lipid reactive oxygen species (lipid ROS), ferrous ion and 4‐hydroxynonenal (4‐HNE) xenograft mouse model, diethylnitrosamine (DEN)‐initiated model so forth. The regulatory mechanisms YBX1...
Disrupted neonatal lung alveologenesis often leads to bronchopulmonary dysplasia (BPD), the most common chronic disease in children. The inhibition of type 2 alveolar (AT2) cell proliferation plays an important role arrest alveologenesis. However, mechanism AT2 retardation BPD is still not fully elucidated. purpose present study was explore effects cyclin G1 (CCNG1) on hyperoxia-induced injury mice. Our findings revealed that hyperoxia significantly reduced proportion cells lungs mice and...
Henry Green’s novel Party Going is a microcosm of the social transformation in Britain during two World Wars. By narrating experiences group affluent young people stranded at London’s Victoria Station, reveals societal issues class conflict, ethical decay and cultural upheaval behind impending war decline empire. This narrative triggers author’s contemplation on disappearance collective memory, represented by wealthy class. Green seamlessly intertwines individual memories, unveiling crises...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editor-in-chief. In investigating concerns image duplications initially raised PubPeer (https://pubpeer.com/publications/4661DB0D531C610DD10E8EAD3C2D97), evidence for duplication in identical or altered fashion Figures 5B, 5C, and 5G, as well manipulation 6D S4F, was identified. addition, an investigation conducted by Supervision...
To study the radiation-sensitizing effect of up-regulating p27(kip1) expression by knocking down miR-221/222 in U251 human glioblastoma cell line.By bioinformatic analysis, we searched miRNA-221/222 sequence and found relationship between miRNA-221/222. antisense oligonucleotides were transfected into cells. Northern blot analysis was conducted to detect control, scrambled oligonucleotide (ODN) anti-mi-221/222ODNs groups. The cycle kinetics detected flow cytometry. Clonogenic assay used...
Background: Cell recognition molecule L1 (L1) plays an important role in cancer cell differentiation, proliferation, migration and survival, but its mechanism remains unclear. Methodology/Principal: Our previous study has demonstrated that enhanced survival neural cells by regulating surface glycosylation. In the present study, we show affected CHO (Chinese hamster ovary) line modulation of sialylation fucosylation at via PI3K (phosphoinositide 3-kinase) Erk (extracellularsignal-regulated...
Neuropilin 1 (NRP1) is a single-channel transmembrane glycoprotein whose role and mechanism in renal fibrosis remain incompletely elucidated. Therefore, we investigated the effect of NRP1 on its potential mechanism. expression sections from patients with chronic kidney disease (CKD) unilateral ureteral obstruction (UUO) mouse model was detected.
Abstract Cell labeling and tracing have played an increasingly important role in the field of stem cell transplantation. Nanocomplexes combining three Food Drug Administration (FDA)‐approved drugs: heparin (H), protamine (P), ferumoxytol (F) (HPF nanocomplexes) display high efficiency human adipose tissue‐derived cells (hADSCs), but their biological safety has not been determined. In this study, we tested HPF hADSCs through vitro cytotoxicity studies vivo murine preclinical using HPF‐labeled...
Abstract Salivary adenoid cystic carcinoma (SACC) is a malignant tumor, which characterized by higher incidence of distant metastasis. The aim this study was to investigate the role and mechanism protein kinase D1 (PKD1) in regulating epithelial–mesenchymal transition (EMT) promotes metastasis SACC. We analyzed expression PKD1 40 SACC patients different metastatic potential cell lines. Then, we investigated whether migration growth were regulated using shRNA interference or inhibition active...
Abstract Background The study of CCR7/CCL19 chemokine axis and BC (BC) prognosis metastasis is a current hot topic. We constructed ceRNA network risk-prognosis model based on CCR7/CCL19. Methods Based the lncRNA, miRNA mRNA expression data downloaded from TCGA database, we used starbase website to find lncRNA established network. 1008 samples containing survival were divided into Train group (504 cases) Test using R "caret" package. Then prognostic risk RNA screened by univariate Cox...
Objective To investigate the radiosensitizing effect of knock-down miR-221 and miR-222 on MCF-7 human breast cancer cells explore possible mechanism. Methods Antisense oligo-nucleotides miR-222( AS-miR-221 AS-miR-222), mediated by lipofectamine, were transfected to knock down miR-222, Northern blotting was conducted detect expression in cells. The cell apoptosis detected flow cytome-try Caspase-3 Caspase-7 activity assay. Clonogenic assay used measure sensitizing en-hancement ratio. Target...