A5062561534- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Apelin-related biomedical research
- Spinal Cord Injury Research
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Gold and Silver Nanoparticles Synthesis and Applications
- Nerve injury and regeneration
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Circular RNAs in diseases
- Adsorption and biosorption for pollutant removal
- Immune cells in cancer
- Advanced Biosensing Techniques and Applications
- Nuclear Receptors and Signaling
- Nerve Injury and Rehabilitation
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Synthetic Organic Chemistry Methods
- Caching and Content Delivery
- Covalent Organic Framework Applications
- Simulation-Based Education in Healthcare
- Spine and Intervertebral Disc Pathology
- Carbon and Quantum Dots Applications
- Gut microbiota and health
- Advanced Data Storage Technologies
Zhengzhou University
2019-2025
China Three Gorges University
2023-2025
Third Xiangya Hospital
2010-2025
Central South University
2010-2025
Southern University of Science and Technology
2025
Yangzhou University
2022-2024
Southeast University
2023
Ningbo College of Health Sciences
2023
Shenzhen Second People's Hospital
2022-2023
Shenzhen University
2023
Abstract Background BM-MSCs play an important role in cancer development through the release of cytokines or exosomes. Studies have shown that extracellular exosomes derived from are a key pro-invasive factor. However, how BM-MSC-exos influence AML cell proliferation, invasion and chemoresistance remains poorly understood. Methods We isolated used electron microscopy, particle size separation western blots to identify The leukemia cells was observed with transwell assay. stemness traits were...
Abstract Objective To investigate the regulatory role of miR-223-3p in inflammatory response PE placenta. Methods and normal placental tissues were collected to measure expression NLRP3 miR-223-3p. The targeting relationship between miR-223-3P was verified by bioinformatics analysis classical double-luciferase reporter gene assay. Lipopolysaccharide (LPS) used induce HTR8/SVneo cells as cell inflammation model. Then we transfected overexpression/miR-223-3p negative control plasmid into...
Abstract Background Acute spinal cord injury (SCI) could cause mainly two types of pathological sequelae, the primary mechanical injury, and secondary injury. The macrophage in SCI are skewed toward M1 phenotype that might failure to post-SCI repair. Methods model was established Balb/c mice, changes phenotypes after were monitored. Bioinformatic analyses performed select factors regulate polarization SCI. Mouse bone marrow-derived macrophages (BMDMs) isolated, identified, induced for or M2...
Circulating tumour DNA (ctDNA) has emerged as an ideal biomarker for the early diagnosis and prognosis of gastric cancer (GC). In this work, a pump-free, high-throughput microfluidic chip coupled with catalytic hairpin assembly (CHA) hybridization chain reaction (HCR) signal cascade amplification strategy (CHA-HCR) was developed surface-enhanced Raman scattering (SERS) assays PIK3CA E542K TP53 (two GC-related ctDNAs). The consisted six parallel functional units, enabling simultaneous...
Spinal cord injury (SCI) makes a major contribution to disability and deaths worldwide. Reactive astrogliosis, typical feature after SCI, which undergoes varying molecular morphological changes, is ubiquitous but poorly understood. astrogliosis contributes glial scar formation that impedes axonal regeneration. Brain-derived neurotrophic factor (BDNF), well-established factor, exerts neuroprotective growth-promoting effects on variety of neuronal populations injury. In the present study, by...
PVA/SA@ZIF-8 was fabricated for enhanced copper adsorption by in situ grafting of ZIF-8 on the surface sodium alginate hydrogel.
A novel SERS biosensor based on cascade signal amplification of CHA-HCR for ultrasensitive detection HPV-E7 and OPN was developed in this work.
A catalytic hairpin assembly-based SERS microfluidic chip was developed for rapid, sensitive, and simultaneous detection of two NSCLC-related ctDNAs.
Background: Traditional Chinese medicines exhibit promising preventive effects on Alzheimer’s disease. Chaihu Shugan San (CSS) is a well-known traditional herbal formula whose several kinds of ingredients have the potential ameliorating The present study aimed to evaluate CSS microbiota–gut–brain axis and cognitive deficits senescence-accelerated mouse prone 8 (SAMP8) mice as well investigate underlying mechanisms. Methods: Thirty 5-month-old SAMP8 were randomly divided into model group...
Abstract A one‐pot synthesis of 2,3,4‐unprotected β‐ N ‐glycopyranosides from glycals and amines with exclusive β‐stereoselectivity under room temperature conditions is reported. This method was achieved via palladium‐catalyzed Tsuji‐Trost amination followed by dihydroxylation directly, tolerating anilines, heterocyclic aromatic amines, , O ‐dimethylhydroxylamine, especially the reaction primary has not been reported before. Furthermore, protocol applied to modify clinical drugs (prazosin,...
Abstract Objective To explore the teaching effect of Advanced Life Support in Obstetrics (ALSO) Course standardized training resident obstetric. Methods 60 residents obstetrics from January 2021 to December 2022 were randomly divided into two groups, observation group and control group. The experimental used ALSO method, traditional method. was evaluated by theoretical examination, direct procedural skills (DOPS) scale mini clinical evaluation (Mini-CEX) scale. Results achievements...
Abstract Purpose This study aims to analyze the clinical characteristics of Chinese children with spinal cord injury (SCI) without radiographic abnormality (SCIWORA) and explore their contributing factors mechanisms occurrence. Methods A retrospective analysis was conducted on data pediatric patients diagnosed SCIWORA from January 2005 May 2020. Epidemiological, etiological, mechanistic, therapeutic, outcome aspects were analyzed. Results total 47 included in this study, comprising 16 males...