A5102027217- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- RNA modifications and cancer
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Chemokine receptors and signaling
- Cancer Mechanisms and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
- MicroRNA in disease regulation
- Antibiotics Pharmacokinetics and Efficacy
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- Spine and Intervertebral Disc Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Genital Health and Disease
Zhengzhou University
2015-2025
First Affiliated Hospital of Zhengzhou University
2015-2025
The clinical application of chemotherapy is impeded by the unsatisfactory efficacy and severe side effects. Chemodynamic therapy (CDT) has emerged as an efficient strategy for cancer treatment utilizing Fenton chemistry to destroy cells converting endogenous H2 O2 into highly toxic reactive oxygen species. Apart from chemotherapeutic effect, cisplatin able act artificial enzyme produce CDT through cascade reactions, thus remarkably improving anti-tumor outcomes. Herein, organic theranostic...
Abstract Background RNA 5‐methylcytosine (m5C) plays an important role in the progression of hepatocellular carcinoma (HCC). Dysregulation ferroptosis is closely associated with HCC. However, effect epigenetic mRNA m5C modification on HCC remains unclear. Methods In this study, was evaluated by detecting lipid reactive oxygen species (lipid ROS), ferrous ion and 4‐hydroxynonenal (4‐HNE) xenograft mouse model, diethylnitrosamine (DEN)‐initiated model so forth. The regulatory mechanisms YBX1...
Abstract Cyclin-dependent kinases (CDKs) play important roles in the development of many types cancers by binding with their paired cyclins. However, function CDK11 larger protein isomer, p110 , tumorigenesis human breast cancer remains unclear. In present study, we explored effects and molecular mechanisms proliferation growth cells determining expression tumor tissues examining phenotypic changes after knockdown. We found that was highly expressed cell lines. Tissue microarray analysis...
Aim: To reveal the prognostic significance of serum albumin (ALB) concentration in endometrial cancer (EC) patients China. Patients & methods: 345 EC were enrolled a single center, and preoperative ALB measured. Kaplan-Meier curve analysis Cox proportional hazards regression model performed to evaluate associations between overall survival (OS) patients. Results: The with lower exhibited significantly poorer OS (p < 0.05). Univariate multivariate indicated that was an independent factor...
Curcumin has been used as an alternative medicine for the treatment of infantile hemangiomas (IHs); however, mechanism underlying effectiveness curcumin in IHs remains largely unclear.In this study, we isolated primary human hemangioma endothelial cells (HemECs) from fresh surgical specimens 3 patients. We treated HemECs by and investigated alterations proliferative apoptotic signaling pathways with cell counting kit-8, flow cytometry, western blotting, immunofluorescence, real-time...
Objectives: Chordomas are slow-growing malignancies that commonly affect vital neurological structures. These neoplasms highly resistant to current chemotherapeutic regimens and often recur after surgical intervention. Therefore, there is an urgent need identify molecular targets more robust drugs improve chordoma patient outcomes. It well accepted cyclin-dependent protein kinase 9 (CDK9) has tumorigenic roles in various cancers; however, the expression significance of CDK9 remains unknown....
Esophageal squamous cell carcinoma (ESCC) is a serious malignancy with limited options for targeted therapy. The exploration of novel therapies combating ESCC urgently needed. Cyclin-dependent kinases (CDKs) play important roles in the progression cancers; however, function CDK11p110 (cyclin-dependent kinase 11p110) still unknown. Here, we investigated effects and molecular mechanisms proliferation growth by examining expression tissues detecting phenotypic changes cells after knockdown or...
This study investigated the quality of life Chinese patients with tongue cancer who had undergone immediate flap reconstruction surgery. In addition, we compared 2 groups patients: those received radial forearm free (RFFF) surgery and others pectoralis major myocutaneous (PMMF) surgery.Patients RFFF or PMMF after primary treated total subtotal resection were eligible for current study. The patients' demographic data, medical history, scores (14-item Oral Health Impact Profile (OHIP-14)...
<b><i>Objective:</i></b> The purpose of the study was to evaluate safety and feasibility treatment for male circumcision using modified sleeve subcuticular suture with Quill™ device. <b><i>Methods:</i></b> From May 2011 March 2012, 70 consecutive cases were performed an alternative technique device by a single surgeon in our institution. inclusion exclusion criteria selection process this procedure same as conventional circumcision. We...
Aim: To compare the bioavailability of two Azithromycin tablet formulations 500 mg Azivol® tablets as test formulation and Zithromax® reference formulation.Methods: A single-dosed, open-label randomized two-way crossover design under fasting period with weeks wash-out was evaluated in 24 subjects.For analysis pharmacokinetic properties, blood samples were drawn taken up to 120 hours after dosing.Plasma concentration determined using liquid chromatography -tandem mass spectrometry method...