A5068494180- Mesenchymal stem cell research
- Otolaryngology and Infectious Diseases
- Hematopoietic Stem Cell Transplantation
- Cancer-related molecular mechanisms research
- Streptococcal Infections and Treatments
- Cancer Cells and Metastasis
- Geomechanics and Mining Engineering
- Tracheal and airway disorders
- Infectious Diseases and Tuberculosis
- Air Quality and Health Impacts
- Acute Myeloid Leukemia Research
- Per- and polyfluoroalkyl substances research
- Proteoglycans and glycosaminoglycans research
- MicroRNA in disease regulation
- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
- China's Socioeconomic Reforms and Governance
- Salivary Gland Tumors Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Signaling Pathways in Disease
- Neurogenetic and Muscular Disorders Research
- Spinal Cord Injury Research
- Adrenal and Paraganglionic Tumors
- Breast Cancer Treatment Studies
- Cerebral Palsy and Movement Disorders
Huazhong University of Science and Technology
2020-2025
First Affiliated Hospital of Dalian Medical University
2015-2025
Dalian Medical University
2015-2025
China Pharmaceutical University
2024
University of Chinese Academy of Sciences
2024
Wuhan No.1 Hospital
2024
Shanghai Jiao Tong University
2008-2024
Shanghai First People's Hospital
2024
University of California, Los Angeles
2023
First Hospital of Jilin University
2015-2023
To appraise effective predictors for COVID-19 mortality in a retrospective cohort study.A total of 1270 patients, including 984 admitted Sino French New City Branch (training and internal validation sets randomly split at 7:3 ratio) 286 Optical Valley (external set) Wuhan Tongji hospital, were included this study. Forty-eight clinical laboratory features screened with LASSO method. Further multi-tree extreme gradient boosting (XGBoost) machine learning-based model was used to rank importance...
Disulfiram (DSF) is an anti-alcoholism medication with superior antitumor activity and clinical safety; its mechanisms in gastric cancer (GC) have not been fully explored. In the present work, low nontoxic concentrations of copper (Cu) ions substantially enhanced DSF's activity, inhibiting proliferation growth GC cell lines. DSF/Cu elevated generation reactive oxygen species (ROS), apoptosis was induced ROS-dependent manner. This process might involve primary inhibition by through induction...
Dementia is an important disease burden among the elderly, and its occurrence may be profoundly affected by environmental factors. Evidence of relationship between air pollution dementia emerging, but extent to which this can offset lifestyle factors remains ambiguous.
Abstract Systemic immune-inflammation index (SII) emerged as a biomarker of chronic inflammation and an independent prognostic factor for many cancers. We aimed to investigate the associations SII level with total cause-specific mortality risks in general populations, potential modification effects lifestyle-related factors on above associations. In this study, we included 30,521 subjects from Dongfeng-Tongji (DFTJ) cohort 25,761 National Health Nutrition Examination Survey (NHANES)...
Abstract Prostate cancer (PCa) causes significant mortality and morbidity, with advanced metastasis. WNT signaling is a promising therapeutic target for metastatic PCa. GIPC2 GIPC1 paralog involved in pathways associated tumor progression, but its role PCa metastasis remains unclear. Herein, we demonstrated that high expression tissues was significantly distant poor prognosis. Functional studies due to CpG-island demethylation promoted increased capabilities of cells. Conversely, silencing...
Breast cancer (BC) is the most common gynecologic tumor worldwide where aberrant expression of microRNAs (miRNAs) frequently involved. Here, we evaluated function miR-375 on BC development and molecules implicated. Differentially expressed genes between paired normal tissues from patients were screened out by microarray analyses. was abundantly in cells, it correlated with poor prognosis patients. Downregulation introduced into cell lines MCF-7 HCC1954, after which viability, colony...
Observational epidemiological studies have reported the associations of high body mass index (BMI) with elevated serum uric acid (UA) level and increased risk postmenopausal breast cancer. However, whether UA is causally induced by BMI functioned in BMI-breast cancer relationship remains unclear.To elucidate causality direction between UA, bidirectional Mendelian randomization (MR) analyses were performed using summarized data from largest Asian genome-wide association (GWAS) carried out...
Tight junctions regulate paracellular permeability, create the luminal fluid microenvironment of blood vessels and digestive tract, also form protective barrier in stratified epithelium including epidermis. Claudins are integral membrane proteins at tight a multigene family composed least 24 members, but knowledge subcellular localization each claudin is still fragmentary. We performed RT-PCR for fifteen species to examine mRNA expression various mouse tissues, focused on investigating...
Circulating white blood cell (WBC) counts have been related to lung function impairment, but causal relationship was not established. We aimed evaluate independent effects and relationships of WBC subtypes with function.The 19,159 participants from NHANES 2011-2012 (n = 3570), coke-oven workers (COW, n 1762) Dongfeng-Tongji (DFTJ, 13,827) cohorts were included in the observational studies. The associations between circulating prebronchodilator evaluated by linear regression models LASSO used...
Administration of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) is believed to be an effective method for treating neurodevelopmental disorders. In this study, we investigated the possibility hUC-MSCs treatment neonatal hypoxic/ischemic brain injury associated with maternal immune activation and underlying mechanism. We established rat models by exposing pregnant rats lipopolysaccharide on day 16 or 17 pregnancy. Rat offspring were intranasally administered postnatal 14....
This study aimed to describe the full scope of long-term outcomes and ongoing pathophysiological alterations among COVID-19 survivors.We established a longitudinal cohort 208 convalescents followed them at 3.3 (interquartile range [IQR]: 1.3, 4.4, visit 1), 9.2 (IQR: 9.0, 9.6, 2), 18.5 18.2, 19.1, 3) months after infection, respectively. Serial changes in multiple physical psychological were comprehensively characterized. We, addition, explored potential risk factors SARS-CoV-2 antibody...
Frailty describes an age-related state of deterioration in biological function. This study aimed to investigate the association between frailty and cognitive function its combined effects with lifestyles.A total 3,279 participants from Dongfeng-Tongji (DFTJ) cohort were tested by using Chinese version Mini-mental State Examination (MMSE). was evaluated based on a 35-item index (FI). status dichotomized into robust (FI < 0.15) frail ≥ 0.15). Multivariate generalized linear regression models...
Background: Descending necrotizing mediastinitis (DNM) is an inflammation occurring in the oropharynx and descending to deep cervical space mediastinum, which a serious infectious disease. The investigation of new classification system treatment methods for DNM still necessary. Methods: A total 139 patients with caused by odontogenic or pharyngeal infection were retrospectively analyzed last 20 years Ninth People's Hospital Affiliated Shanghai Jiao Tong University School Medicine. divided...
Exposure to benzo[a]pyrene (BaP) could lead the development of lung cancer, but potential mechanisms are complex and remain largely unclear. Plasma tRNA-derived small RNA (tsRNA), a new type epigenetic biomarker might link environment exposure with cancer. Based on this case-control study 272 participants recruited from China, we aim reveal plasma tsRNA signature cancer their mediation effects BaP-induced We sequenced profiles detected adducts Benzo[a]pyrene diol epoxide-albumin (BPDE-Alb)...