A5101549791- Plant Stress Responses and Tolerance
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Plant Molecular Biology Research
- Aluminum toxicity and tolerance in plants and animals
- Effects of Radiation Exposure
- Plant responses to water stress
- RNA Interference and Gene Delivery
- Photosynthetic Processes and Mechanisms
- Biocrusts and Microbial Ecology
- Cardiac Ischemia and Reperfusion
- Chemotherapy-induced cardiotoxicity and mitigation
- Nutritional Studies and Diet
- RNA modifications and cancer
- Plant nutrient uptake and metabolism
- Plant Water Relations and Carbon Dynamics
- Transition Metal Oxide Nanomaterials
- Breast Implant and Reconstruction
- PARP inhibition in cancer therapy
- Breast Lesions and Carcinomas
- Diet and metabolism studies
- Mesenchymal stem cell research
- Natural Compounds in Disease Treatment
- Trace Elements in Health
Yan'an Hospital Affiliated To Kunming Medical University
2019-2025
Kunming Medical University
2019-2025
Huazhong University of Science and Technology
2014-2025
Northwest A&F University
2020-2024
The Fifth People’s Hospital of Suzhou
2023
Gansu Provincial Cancer Hospital Gansu Provincial Academic Instiute for Medical Research
2020-2023
Northwest Institute of Mechanical and Electrical Engineering
2023
Academy of Medical Sciences
2023
Lanzhou University
2016-2022
Ministry of Agriculture and Rural Affairs
2015-2022
Atriplex canescens (fourwing saltbush) is a C4 perennial fodder shrub with excellent resistance to salinity. However, the mechanisms underlying salt tolerance in are poorly understood. In this study, 5-week-old A. seedlings were treated various concentrations of external NaCl (0-400 mM). The results showed that growth was significantly stimulated by moderate salinity (100 mM NaCl) and unaffected high (200 or 400 NaCl). Furthermore, higher photosynthetic capacity under treatments (except for...
Chloride (Cl-) is pervasive in saline soils, and research on its influence plants has mainly focused role as an essential nutrient toxicity when excessive accumulation occurs. However, the possible functions of Cl- adapting to abiotic stresses have not been well documented. Previous studies shown that salt tolerance xerophytic species Pugionium cornutum might be related high accumulation. In this study, we investigated Cl--tolerant characteristics physiological drought resistance P....
Increasing evidence indicates that many small secretory preproteins can undergo post-translational translocation across the membrane of endoplasmic reticulum. Although cellular machinery involved in has begun to be elucidated, intrinsic signals contained within these contribute their efficient remain unknown. Here, we analyzed eukaryotic proteome and discovered tend have a higher probability harbor positive charge n-region signal peptide (SP). Eliminating blocked newly synthesized...
Atriplex canescens is a typical C4 secretohalophyte with salt bladders on the leaves. Accumulating excessive Na+ in tissues and bladders, maintaining intracellular K+ homeostasis increasing leaf organic solutes are crucial for A. survival harsh saline environments, enhanced photosynthetic activity water balance promote its adaptation to salt. However, molecular basis these physiological mechanisms poorly understood. Four-week-old seedlings were treated 100 mM NaCl 6 24 h, differentially...
Epidemiologic studies have reported the positive relationship of benzo[a]pyrene (BaP) exposure with risk lung cancer. However, mechanisms underlying is still unclear. Plasma microRNA (miRNA) a typical epigenetic biomarker that was linked to environment and cancer development. We aimed reveal mediation effect plasma miRNAs on BaP-related designed case-control study including 136 patients controls, measured adducts diol epoxide-albumin (BPDE-Alb) sequenced miRNA profiles in plasma. The...
We previously identified five polycyclic aromatic hydrocarbons (PAHs)-associated microRNAs (miRNAs) and found they were associated with chromosome damage. As oxidative damage is the common contributory cause of various PAHs-related diseases, we further investigated influences these miRNAs their interactions environmental factors on DNA lipid peroxidation. measured PAHs internal exposure biomarkers [urinary monohydroxy-PAHs (OH-PAHs) plasma...
Abstract Berries are dietary plants with high antioxidant activity. The aim of this study is to investigate the protective effect berries (strawberry, grape, and blueberry) against acrylamide (AA)‐induced general toxicity, genotoxicity, reproductive toxicity in mice model, respectively. Mice were treated 50 mg/kg b.w./day AA intraperitoneal injection for 5 d after feeding control diet or containing freeze‐dried strawberry, blueberry powder. results showed that induced a significant mice....
Objective To explore differentially expressed miRNAs in type 2 diabetes and their potential cellular functions. Methods We screened plasma by miRNA array analysis validated them TaqMan real-time PCR 113 newly diagnosed, untreated cases healthy controls. Low-abundance proteins encoded miR-193b-3p target genes were explored this study population. further investigated the functions of HepG2 cells. Results was compared to controls (fold change = 2.01, P 0.006). Plasma levels triosephosphate...
Exposure to benzo[a]pyrene (BaP) could lead the development of lung cancer, but potential mechanisms are complex and remain largely unclear. Plasma tRNA-derived small RNA (tsRNA), a new type epigenetic biomarker might link environment exposure with cancer. Based on this case-control study 272 participants recruited from China, we aim reveal plasma tsRNA signature cancer their mediation effects BaP-induced We sequenced profiles detected adducts Benzo[a]pyrene diol epoxide-albumin (BPDE-Alb)...
Abstract Background: Phosphorylation is a critical post-translational modification regulating key biological processes. CDC20 regulator in cell cycle control, but its phosphorylation's role Uterine Corpus Endometrial Carcinoma (UCEC) not well understood. Methods: We used two datasets from the Clinical Proteomic Tumor Analysis Consortium (CPTAC). PDC000126 was training set, and PDC000441 for validation. Both contained proteomic phosphoproteomic data. Differentially expressed phosphorylation...
Radix Angelica Sinensis and Hedysari are traditional Chinese medicines that used for preventing treating various diseases. This study aimed to investigate the effect possible underlying mechanisms of ultrafiltration extract (RAS-RH) on X-irradiation-induced cardiac fibrosis in rats. Our data demonstrated (a) a single dose total body irradiation (TBI) at 8 Gy resulted fibrosis, whereas control hearts exhibited less collagen fibrosis. RAS-RH mitigated these morphological injuries. (b) TBI an...
Sweet sorghum is an important bioenergy grass and valuable forage with a strong adaptability to saline environments. However, little known about the mechanisms of sweet coping ion toxicity under salt stresses. Here, we first evaluated tolerance cultivar "Lvjuren" determined its accumulation traits NaCl treatments; then, explored key genes involved in Na+, Cl-, K+ NO3- transport using transcriptome profiling qRT-PCR method. The results showed that growth photosynthesis were unaffected by 50...
Ionizing radiation exposure is associated with a risk of cardiac fibrosis; however, the underlying molecular mechanism remains unclear. Growth/differentiation factor-15 (GDF15), fibroblast factor, divergent member transforming growth factor β superfamily. Next-generation sequencing analyses has revealed that Gdf15 increased in fibroblasts during radiation-induced fibrosis. However, role fibrosis In this study, we demonstrated upregulated expression GDF15 newborn rat and adult rats after...
The xerophyte Pugionium cornutum adapts to salt stress by accumulating inorganic ions (e.g., Cl-) for osmotic adjustment and enhancing the activity of antioxidant enzymes, but associated molecular basis remains unclear. In this study, we first found that P. could also maintain cell membrane stability due its prominent ROS-scavenging ability exhibits efficient carbon assimilation capacity under stress. Then, candidate genes with important physiological traits tolerance were identified through...
Metals in the human body represent both environmental exposure and nutritional status. Little is known about miRNA signature relation to circulating metals humans. To characterize metal-associated miRNAs leukocytes, individually collectively as networks. In a panel of 160 Chinese adults, we measured 23 metals/metalloids plasma, sequenced mRNAs leukocytes. We used linear regression model associations between ln-transformed metal concentrations normalized levels adjusting for potential...
Atriplex canescens is a representative halophyte with excellent tolerance to salt. Previous studies have revealed certain physiological mechanisms and detected functional genes associated salt tolerance. However, knowledge on the ROS scavenging system regulatory in this species when adapting salinity limited. Therefore, study further analyzed transcriptional changes related important A. under saline conditions using our previous RNA sequencing data. The Gene Ontology (GO) Kyoto Encyclopedia...
Prostate cancer is the most common malignant urinary tumor among men. Treatments are currently unsatisfactory for advanced prostate cancer. Cancer biology remains basis developing new antitumor drugs. Therefore, it crucial to study metabolic reprogramming, immune microenvironment, and evasion of tumors. This aimed clarify relationship between glycolysis function in