A5101426702- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Respiratory viral infections research
- Cancer-related gene regulation
- Lipid metabolism and disorders
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Tuberculosis Research and Epidemiology
- Protease and Inhibitor Mechanisms
- Mycobacterium research and diagnosis
- Acute Myocardial Infarction Research
- Hepatitis Viruses Studies and Epidemiology
- Viral Infections and Outbreaks Research
- Gallbladder and Bile Duct Disorders
- Neuroscience and Neuropharmacology Research
Qidong Liver Cancer Prevention Research
2014-2025
Shenzhen Center for Disease Control and Prevention
2010-2025
Shanghai Jiao Tong University
2011-2025
Fifth Hospital of Shijiazhuang
2010-2025
Zhejiang Chinese Medical University
2025
Enshi Tujia and Miao Autonomous Prefecture Academy of Agricultural Sciences
2024
The First People's Hospital of Shunde
2008-2024
Southern Medical University
2016-2024
Zhujiang Hospital
2021-2024
Central South University of Forestry and Technology
2024
Abstract Background Since December 2019, SARS-CoV-2 has extended to most parts of China with >80 000 cases and at least 100 countries >60 international as 15 March 2020. Here we used a household cohort study determine the features transmission COVID-19. Methods A total 105 index patients 392 contacts were enrolled. Both members tested by RT-PCR. Information on all recruited individuals was extracted from medical records confirmed or supplemented telephone interviews. The...
The early detection of hepatocellular carcinoma (HCC) presents a challenge because the lack specific biomarkers. Serum/plasma microRNAs (miRNAs) can discriminate HCC patients from controls. We aimed to identify and evaluate HCC‐associated plasma miRNAs originating liver as biomarkers for detecting HCC. In this multicenter three‐phase study, we first performed screening using both (HCC before after transplantation or hepatectomy) tissue samples (HCC, para‐carcinoma cirrhotic tissues). Then,...
Neonatal hepatitis B vaccination has been implemented worldwide to prevent virus (HBV) infections. Its long-term protective efficacy on primary liver cancer (PLC) and other diseases not fully examined.The Qidong Hepatitis Intervention Study, a population-based, cluster randomized, controlled trial between 1985 1990 in Qidong, China, included 39,292 newborns who were randomly assigned the group which 38,366 participants completed HBV series 34,441 control received neither vaccine nor placebo....
Neuroinflammation has been reported to be associated with Alzheimer's disease (AD) pathogenesis. is generally considered as an outcome of glial activation; however, we recently demonstrated that T helper (Th)17 cells, a subpopulation proinflammatory CD4+ are also involved in AD Transforming growth factor (TGF)-β1, cytokine can expressed the brain, immunosuppressive, but its effects on lymphocyte-mediated neuroinflammation pathogenesis have not well addressed. In current study administered...
A population-based cancer registry was established in Qidong, Jiangsu Province, China, 1972, and the trends incidence rates of major sites have been analyzed for a 25-year period, 1978-2002. Five-year age-specific rates, crude world age-standardized (ASR), percent change (PC) annual (APC) were calculated using data on population size, estimates its age structure. The indices histological verification diagnosis, death certificate only proportion mortality to employed assessing registration...
Qidong City, China, has had high liver cancer incidence from endemic hepatitis B virus (HBV) infection and dietary exposure to aflatoxin. Based on etiologic studies, we began interventions in 1980 reduce aflatoxin initiate neonatal HBV vaccination. We studied trends rates the 1.1 million inhabitants of examined exposure, staple food consumption, markers annual income. Aflatoxin declined greatly association with economic reform, increased earnings educational programs shift consumption total...
Gallbladder cancer (GBC), highly aggressive form of with an extremely poor prognosis, is the most common malignancy biliary tract.In this study, we investigated effects dioscin (DSN) on human GBC and potential mechanisms underlying these effects.The results showed that DSN significantly inhibited cell proliferation migration.Moreover, induced apoptosis via mitochondrial dependent apoptotic signalling.Reactive oxygen species (ROS) glutathione (GSH) levels were measured, ROS scavengers...
The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet been completely clarified. Disease-specific treatments are lacking, and care is still based on supportive modalities. aim of our study was to assess the protective effects melatonin cardiomyopathy, with a focus interactions between receptor-interacting protein kinase 3 (Ripk3), mitochondria, endoplasmic reticulum (ER) cytoskeletal degradation in cardiomyocytes. Ripk3 expression increased heart samples...
Abstract Background & Aims Whether nonalcoholic fatty liver disease (NAFLD) is associated with risk of incident atrial fibrillation (AF) independent established cardiovascular factors remains controversial. We aimed to provide a quantitative estimate the association between NAFLD and AF after adjustment for cardiometabolic factors. Methods In this study, we searched PubMed Embase studies published from database inception until January 31, 2020. Cohort reported adjusted relative risks...
Abstract While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected are asymptomatic. We sought to identify the distinction of immune response between asymptomatic and moderate patients. performed single-cell transcriptome T-cell/B-cell receptor (TCR/BCR) sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic, moderate, patients with healthy controls....
Abstract Background Studies have revealed that visiting poultry markets and direct contact with sick or dead are significant risk factors for H5N1 infection, the practices of which could possibly be influenced by people's knowledge, attitudes (KAPs) associated avian influenza (AI). To determine KAPs AI among Chinese general population, a cross-sectional survey was conducted in China. Methods We used standardized, structured questionnaires distributed both an urban area (Shenzhen, Guangdong...
Casticin, the flavonoid extracted from Vitex rotundifolia L, exerts various biological effects, including anti-inflammatory and anti-cancer activity. The aim of this study is to investigate effects mechanisms casticin in human gallbladder cancer cells.Human NOZ SGC996 cells were used perform experiments. CCK-8 assay colony formation performed evaluate cell viability. Cell cycle analyses annexin V/PI staining for apoptosis measured using flow cytometry. Western blot analysis was changes...
Transforming growth factor (TGF)-β1, a cytokine that can be expressed in the brain, is key regulator of brain’s responses to injury and inflammation. Alzheimer’s disease (AD), most common neurodegenerative disorder, involves inflammatory processes brain addition hallmarks, amyloid-β (Aβ) plaques neurofibrillary tangles. Recently, we have shown T-helper (Th) 17 cells, subpopulation CD4+ T-cells with high proinflammation, also participate process AD. However, it poorly known whether TGF-β1...
Magnolol, the major active compound found in Magnolia officinalis has a wide range of clinical applications due to its anti-inflammation and anti-oxidation effects. This study investigated effects magnolol on growth human gallbladder carcinoma (GBC) cell lines. The results indicated that could significantly inhibit GBC lines dose- time-dependent manner. Magnolol also blocked cycle progression at G0 /G1 phase induced mitochondrial-related apoptosis by upregulating p53 p21 protein levels...
// Yingqing Li 1,* , Jianhua Lu Xueming Bao 1 Xifu Wang Junhua Wu Xiongbin and Weiqiang Hong Department of Emergency, Guangzhou First People’s Hospital, Medical University, Guangzhou, Republic China * These authors have contributed equally to this article Correspondence to: Li, email: Keywords : miR-499-5p; acute myocardial infarction; cardiomyocytes apoptosis; ischaemic injury; programmed cell death 4; Pathology Section Received March 03, 2016 Accepted May 17, Published 25, Abstract...